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    BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF
    8.
    发明申请
    BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
    双相PYRANONE衍生物及其使用方法

    公开(公告)号：US20110243940A1

    公开(公告)日：2011-10-06

    申请号：US13139890

    申请日：2009-12-15

    申请人： Dong Xiao ,  Anandan Palani ,  Xianhai Huang ,  Xiaohong Zhu ,  Robert G. Aslanian

    发明人： Dong Xiao ,  Anandan Palani ,  Xianhai Huang ,  Xiaohong Zhu ,  Robert G. Aslanian

    IPC分类号： A61K39/395 ,  C07D491/052 ,  A61K31/435 ,  A61K31/505 ,  A61K31/47 ,  A61K31/397 ,  A61K31/60 ,  A61K31/4162 ,  A61P3/10 ,  A61P35/00 ,  A61P11/00 ,  A61P1/00 ,  A61P25/00 ,  A61P3/04

    CPC分类号： C07D491/052

    摘要： The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complication, obesity, an obesity-related disorder or non-alcoholic fatty liver disease. Formula (I). Y is —C— when an optional and additional bond is present and Y is —CH— when an optional and additional bond is not present; Z is —O—, —NH— or —N(alkyl)- when the optional and additional bond between Y and Z Is absent, and Z Is —N— when the optional and additional bond between Y and Z is present; R1 is H1 halo or —CN; R2 is alkyl, alkenyl or -(alkyleneVcydoalkyl; t is 0 or 1; R3 is O when the optional and additional bond between Y and R3 is present, and R3 is alkyl.haloalkyl.—C(0)0R5.-alkylene-O-alkyt or —O-alkyl when the optional and additional bond between Y and R3 is absent: R4 is H, alkyl or aryl, wherein an aryl group can be unsubstituted or optionally substituted.

    摘要翻译： 本发明涉及双环吡喃酮衍生物，其组合物和用于治疗或预防代谢紊乱，血脂异常，心血管疾病，神经障碍，血液病，癌症，炎症，呼吸系统疾病，胃肠病，糖尿病， 糖尿病并发症，肥胖症，肥胖相关障碍或非酒精性脂肪性肝病。 式（I）。 当不存在任选和另外的键时，当存在任选的附加键且Y是-CH-时，Y是-C-; 当Y和Z之间的任选和另外的键不存在时，Z是-O - ， - NH-或-N（烷基），当存在Y和Z之间的任选的和另外的键时，Z是 - R1为H1卤素或-CN; R 2是烷基，烯基或 - （亚烷基二烷基; t是0或1;当存在Y和R 3之间的任选和另外的键时，R 3是O，R 3是烷基卤代烷基-C（O） - 烷基或-O-烷基，当Y和R3之间的任选和另外的键不存在时：R4是H，烷基或芳基，其中芳基可以是未取代的或任选被取代的。