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110 条记录 (耗时 0.076 秒)

    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
    72.
    发明授权
    Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane 失效
    2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷的抗病毒活性和拆分

    公开(公告)号：US06642245B1

    公开(公告)日：2003-11-04

    申请号：US08475339

    申请日：1995-06-07

    申请人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    发明人： Dennis C. Liotta ,  Raymond F. Schinazi ,  Woo-Baeg Choi

    IPC分类号： A61K31506

    CPC分类号： C07D327/04 ,  A61K31/513 ,  C07D405/04 ,  C07D411/04 ,  C07H19/06 ,  C07H19/10 ,  Y10S514/885

    摘要： A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.

    摘要翻译： 公开了用于治疗人体中HIV和HBV感染的方法和组合物，其包括给予有效量的2-羟甲基-5-（5-氟胞嘧啶-1-基）-1,3-氧硫杂环戊烷，其药学上可接受的衍生物 包括在药学上可接受的载体中包括5'或N 4烷基化或酰化衍生物或其药学上可接受的盐。还公开了用于拆分核苷对映异构体外消旋混合物的方法，其包括将 外消旋混合物到优先催化其中一种对映异构体中的反应的酶。

    [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
    73.
    发明授权
    [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides 失效
    [5-羧甲酰氨基或5-氟] - [2'，3'-不饱和或3'-修饰] - 嘧啶核苷

    公开(公告)号：US06391859B1

    公开(公告)日：2002-05-21

    申请号：US09677161

    申请日：2000-10-02

    申请人： Raymond F. Schinazi ,  Dennis C. Liotta

    发明人： Raymond F. Schinazi ,  Dennis C. Liotta

    IPC分类号： A01N4304

    CPC分类号： A61K31/7068 ,  A61K31/70 ,  A61K45/06 ,  C07H19/06 ,  A61K2300/00

    摘要： A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于治疗人和其他宿主动物中的HIV和HBV感染的方法和组合物，其包括给予有效量的[5-甲酰氨基或5-氟] -2'，3'-二脱氧-2' ，3'-二脱氢嘧啶核苷或[5-甲酰氨基或5-氟] -3'-修饰的嘧啶核苷或其混合物或药学上可接受的衍生物，包括5'或N4烷基化或酰化衍生物，或 其药学上可接受的盐在药学上可接受的载体中。

    Treatment of HIV by administration of &bgr;-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC)
    76.
    发明授权
    Treatment of HIV by administration of &bgr;-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC) 失效
    通过给予β-D-2'，3'-二脱氢-2'，3'-二脱氧-5-氟胞苷（D4FC）治疗HIV，

    公开(公告)号：US06232300B1

    公开(公告)日：2001-05-15

    申请号：US09310823

    申请日：1999-05-12

    申请人： Raymond F. Schinazi ,  Dennis C. Liotta

    发明人： Raymond F. Schinazi ,  Dennis C. Liotta

    IPC分类号： A61K3170

    CPC分类号： A61K31/7068 ,  A61K31/70 ,  A61K45/06 ,  C07H19/06 ,  A61K2300/00

    摘要： A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于治疗人和其他宿主动物中的HIV和HBV感染的方法和组合物，其包括给予有效量的[5-甲酰氨基或5-氟] -2'，3'-二脱氧-2' ，3'-二脱氢嘧啶核苷或[5-甲酰氨基或5-氟] -3'-修饰的嘧啶核苷或其混合物或药学上可接受的衍生物，包括5'或N4烷基化或酰化衍生物，或 其药学上可接受的盐在药学上可接受的载体中。