公开(公告)号：US5202457A

公开(公告)日：1993-04-13

申请号：US920526

申请日：1992-07-28

申请人： Kazutoshi Miyazawa ,  Naoyuki Yoshida

发明人： Kazutoshi Miyazawa ,  Naoyuki Yoshida

IPC分类号： C07C69/732 ,  C07C69/734

CPC分类号： C07C69/734 ,  C07C69/732

摘要： The invention relates to optically active alkyl 3-aryl-3-hydroxypropionates represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen, hydroxyl, alkoxy of 1-4 carbon atoms, benzyloxy, flurorine, chlorine or bromine and R.sup.6 is alkyl, and a method for producing the above compounds.

摘要翻译： 本发明涉及由以下通式表示的光学活性烷基3-芳基-3-羟基丙酸酯：其中R 1，R 2，R 3，R 4和R 5是氢，羟基，1-4个碳原子的烷氧基，苄氧基 氟磺酸，氯或溴，R6为烷基，以及上述化合物的制造方法。

公开(公告)号：US5076947A

公开(公告)日：1991-12-31

申请号：US361864

申请日：1989-06-06

申请人： Masakazu Kaneoya ,  Manabu Uchida ,  Naoyuki Yoshida ,  Kazutoshi Miyazawa

发明人： Masakazu Kaneoya ,  Manabu Uchida ,  Naoyuki Yoshida ,  Kazutoshi Miyazawa

IPC分类号： C07C33/20 ,  C07C41/00 ,  C07C43/18 ,  C07C43/196 ,  C07C43/205 ,  C07C43/23 ,  C07C67/00 ,  C07C69/94 ,  C07C255/46 ,  C07C255/53 ,  C07C255/55 ,  C07C255/57 ,  C07D213/30 ,  C07D213/79 ,  C07D213/80 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C09K19/20 ,  C09K19/30 ,  C09K19/34 ,  C09K19/54

CPC分类号： C07D213/30 ,  C07C255/53 ,  C07C255/55 ,  C07C255/57 ,  C07C33/20 ,  C07C43/196 ,  C07C43/23 ,  C07D213/79 ,  C07D213/80 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C09K19/2028 ,  C09K19/3068 ,  C09K19/3444 ,  C09K19/3463

摘要： An optically active compound having a high twistability and almost no change in the intrinsic pitch depending on temperature, and a liquid crystal composition comprising the compound are provided, which optically active compound is expressed by the formula ##STR1## wherein R.sup.1 and R.sup.2 each represent 1-20C alkyl or alkoxy, halogen or H; l, m and n each represent 0 or 1; and ##STR2## wherein Y represents H, halogen or cyano.

公开(公告)号：US5017573A

公开(公告)日：1991-05-21

申请号：US384766

申请日：1989-07-25

申请人： Tatsuya Kon ,  Shiro Kato ,  Toshiya Morie ,  Tadahiko Karasawa ,  Naoyuki Yoshida

发明人： Tatsuya Kon ,  Shiro Kato ,  Toshiya Morie ,  Tadahiko Karasawa ,  Naoyuki Yoshida

IPC分类号： A61K31/55 ,  A61P1/00 ,  A61P1/08 ,  A61P9/00 ,  A61P25/00 ,  A61P25/04 ,  A61P43/00 ,  C07D243/08 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

CPC分类号： C07D401/14 ,  C07D243/08 ,  C07D403/12 ,  C07D405/14

摘要： An indazole-3-carboxylic acid derivative represented by the following general formula (I) or its physiologically acceptable acid addition salt or quaternary ammonium salt, ##STR1## wherein Y represents --NH-- or --O--; R.sub.1 and R.sub.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, a substituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a cycloalkenyl group, a lower alkynyl group, an unsubstituted or substituted aryl-lower alkyl group, a lower alkoxycarbonyl group, an unsubstituted or substituted aralkyloxycarbonyl group or an acyl group, or R.sub.1 and R.sub.2, taken together, form a lower alkylene group; R.sub.3 represents a hydrogen atom, a lower alkyl group, or a phenyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group, a substituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a cycloalkenyl group, a lower alkynyl group, an unsubstituted or substituted aryl-lower alkyl group, a lower alkoxycarbonyl group, an unsubstituted or substituted aralkyloxycarbonyl group or an acyl group; R.sub.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group, a nitro group, an amino group or an acylamino group; m represents a number of 1, 2, 3 or 4; n represents a number of 1, 2 or 3; and p represents a number of 1, 2, 3 or 4.This compound is useful as a potent and selective antagonist of serotonin 3 (5--HT.sub.3) receptor.