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公开(公告)号：US20080199412A1
公开(公告)日：2008-08-21
申请号：US12100922
申请日：2008-04-10
CPC分类号： A61K8/33 , A61K8/81 , A61K8/8164 , A61K2800/52 , A61Q11/00
摘要： An anti-staining, antibacterial dentifrice comprises an anti-staining effective amount of an orally acceptable polymer or copolymer that comprises a plurality of monomeric groups of formula (I) wherein (a) one of A and A′ is hydrogen and the other is a moiety (X)n(R)m, (b) n in individual such moieties is independently 0 or 1, (c) linking groups X if present independently comprise an oxygen, sulfur, nitrogen, phosphorus or silicon atom, (d) where n is 0, m is 1, and where n is 1, m is independently an integer from 1 to 3 as determined by X, (e) terminal groups R are independently hydrogen or C1-18 organic radicals, and (t) M and M′ are independently selected from hydrogen, alkali metal and ammonium; said polymer or copolymer having an average molecular weight of at least about 1,000. The dentifrice further comprises an antibacterial effective amount of an orally acceptable halogenated diphenylether antibacterial agent, and an antibacterial enhancing effective amount of an orally acceptable polyvinylmethylether/maleic anhydride copolymer.
摘要翻译： 抗污染的抗菌洁齿剂包括抗染色有效量的口服可接受的聚合物或共聚物，其包含多个式（I）的单体基团，其中（a）A和A'之一是氢，另一个是 部分（X）单独的这些部分中的（b）n独立地为0或1，（c）连接基团X（如果存在）独立地包含氧 ，硫，氮，磷或硅原子，（d）其中n为0，m为1，n为1，m为独立地为1至3的整数，（e）端基R独立地为 氢或C 1-18个有机基团，和（t）M和M'独立地选自氢，碱金属和铵; 所述聚合物或共聚物的平均分子量至少约为1,000。 洁齿剂还包含抗菌有效量的口服可接受的卤化二苯醚抗菌剂，以及抗菌增强有效量的口服可接受的聚乙烯基甲基醚/马来酸酐共聚物。
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公开(公告)号：US20060193791A1
公开(公告)日：2006-08-31
申请号：US11375346
申请日：2006-03-14
申请人： Thomas Boyd , Guofeng Xu , Abdul Gaffar , David Viscio
发明人： Thomas Boyd , Guofeng Xu , Abdul Gaffar , David Viscio
IPC分类号： A61K8/43
摘要： The invention provides oral compositions including a safe and effective amount of a compound represented by the formula (I): wherein R1 and R2 are independently selected from a hydrogen atom and an alkyl group and X− is an anion, and n is an integer of 1 to 25; and (b) a surfactant.
摘要翻译： 本发明提供口服组合物，其包括安全有效量的由式（I）表示的化合物：其中R 1和R 2独立地选自氢原子和 烷基，X - 为阴离子，n为1〜25的整数， 和（b）表面活性剂。
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公开(公告)号：US20060140881A1
公开(公告)日：2006-06-29
申请号：US11301098
申请日：2005-12-12
申请人： Guofeng Xu , Thomas Boyd , Zhigang Hao , David Viscio , Abdul Gaffar , Sarita Mello , Evangelia Arvanitidou , Michael Prencipe
发明人： Guofeng Xu , Thomas Boyd , Zhigang Hao , David Viscio , Abdul Gaffar , Sarita Mello , Evangelia Arvanitidou , Michael Prencipe
IPC分类号： A61K8/49
CPC分类号： A61K8/347 , A61K8/345 , A61K8/498 , A61K8/8164 , A61Q11/00
摘要： Oral care compositions containing: a free-B-ring flavonoid and a flavan; as well as at least one bioavailability-enhancing agent are provided. Methods of using the oral compositions are also provided.
摘要翻译： 口服护理组合物，含有：B型环形黄酮和黄烷; 以及至少一种生物利用度增加剂。 还提供了使用口腔组合物的方法。
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公开(公告)号：US20050271602A1
公开(公告)日：2005-12-08
申请号：US10859412
申请日：2004-06-02
摘要： A method for inhibiting chemical staining of a dental surface comprises contacting the dental surface, prior to said staining, with an orally acceptable polymer or copolymer comprising a plurality of monomeric groups of formula (I) wherein (a) one of A and A′ is hydrogen and the other is a moiety (X)n(R)m, (b) n in individual such moieties is independently 0 or 1, (c) linking groups X if present independently comprise an oxygen, sulfur, nitrogen, phosphorus or silicon atom, (d) where n is 0, m is 1, and where n is 1, m is independently an integer from 1 to 3 as determined by X, (e) terminal groups R are independently hydrogen or C1-18 organic radicals, and (f) M and M′ are independently selected from hydrogen, alkali metal and ammonium; said polymer or copolymer having an average molecular weight of at least about 1,000.
摘要翻译： 用于抑制牙齿表面的化学染色的方法包括在所述染色之前使牙齿表面与包含多个式（I）的单体基团的口腔可接受的聚合物或共聚物接触，其中（a）A和A'之一为 氢和另一个是单独的这样的部分中的部分（X），（b）n独立地为0或1，（c）连接基团X 如果独立地包含氧，硫，氮，磷或硅原子，（d）其中n为0，m为1，并且其中n为1，m独立地为通过X确定的1至3的整数，（e ）末端基团R独立地为氢或C 1-18个有机基团，和（f）M和M'独立地选自氢，碱金属和铵; 所述聚合物或共聚物的平均分子量至少约为1,000。
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公开(公告)号：US20050027001A1
公开(公告)日：2005-02-03
申请号：US10875059
申请日：2004-06-23
申请人： Thomas Boyd , Abdul Gaffar , David Viscio
发明人： Thomas Boyd , Abdul Gaffar , David Viscio
摘要： A stable aqueous antiplaque oral composition containing (a) an antibacterial ester compound having the formula where R1 is an alkyl chain of 1 to 8 carbon atoms, and R2 is an alkyl chain of 6 to 30 carbon atoms and X is an anion.(b) a stabilizing surfactant; and (c) a humectant. Methods of making the oral composition are also provided.
摘要翻译： 一种稳定的水性抗菌素口服组合物，其含有（a）具有下式的抗菌酯化合物，其中R 1是1至8个碳原子的烷基链，R 2是6至30个碳原子的烷基链，X （b）稳定表面活性剂; 和（c）保湿剂。 还提供了制备口腔组合物的方法。
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