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71.发明授权公开(公告)号：US06875564B2
公开(公告)日：2005-04-05
申请号：US10241604
申请日：2002-09-12
申请人： Makoto Kikuchi , Mikio Ihama
发明人： Makoto Kikuchi , Mikio Ihama
CPC分类号： G03C1/0051 , G03C2001/0055 , G03C2001/0058 , G03C2001/03552
摘要： A silver halide photographic emulsion comprising grains, wherein 50% or more (numerical ratio) of all the grains are occupied by tabular grains with epitaxial junction meeting the requirements (i) to (v): (i) silver iodochlorobromide grains having (111) faces as main planes and having two parallel twin planes, (ii) an equivalent circle diameter of 3.0 μm or more and an aspect ratio of 8 or more, (iii) each of host tabular grains has six silver halide epitaxial junction portions selectively in apex portions thereof, (iv) at least one of the silver halide epitaxial junction portions has at least one dislocation line, and (v) a spacing between the two parallel twin planes of 0.012 μm or less.
摘要翻译： 包含晶粒的卤化银照相乳剂，其中所有晶粒的50％以上（数值比）被具有满足（i）至（v）的要求的外延结构的片状晶粒占据：（i）具有（111）的碘代氯溴化银粒子， （ii）等效圆直径为3.0μm以上，纵横比为8以上，（iii）主体片状颗粒中的每一个均具有选择性地在顶点的六个卤化银外延连接部分 （iv）卤化银外延结部分中的至少一个具有至少一个位错线，（v）两个平行双面之间的间隔为0.012μm或更小。
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公开(公告)号：US06610467B2
公开(公告)日：2003-08-26
申请号：US09953289
申请日：2001-09-17
申请人： Masahiro Asami , Makoto Kikuchi , Tadanobu Sato
发明人： Masahiro Asami , Makoto Kikuchi , Tadanobu Sato
IPC分类号： G03C1025
CPC分类号： G03C1/08 , G03C1/0051 , G03C1/42 , G03C8/4013 , G03C8/404 , G03C2001/0056 , G03C2200/43
摘要： There is disclosed a silver halide photographic emulsion comprising silver halide grains, wherein 50% or more of the projected area of the silver halide grains to be contained is occupied by tabular grains having an aspect ratio of 2 or more and a grain thickness of 0.2 &mgr;m or less, with the tabular grains each having a phase with the content of silver bromide being 10% or more, and wherein in the phase, the tabular grains each contain a metal complex dopant in an amount necessary to increase the density of a dislocation. This emulsion produces high contrast and better granularity while it has high sensitivity. Further, there is also disclosed a silver halide photographic emulsion, wherein the average equivalent-circle diameter of the total tabular grains among the silver halide grains contained is 2.0 to 4.0 &mgr;m, and the tabular grains contain at least one metal complex having, as a ligand, a heterocyclic compound in a number more than half of the coordination number of the metal atom. This emulsion has high sensitivity and excellent photographic characteristics exhibiting little change of gradation upon exposure to high-intensity illumination. In addition, the present invention provides a silver halide color photographic light-sensitive material using the emulsion, and a color image forming process that is simple and rapid and places little load on the environment, using the material.
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73.发明授权Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells 有权包含中期因子或多余肌营养蛋白的组合物和增加造血细胞的方法公开(公告)号：US06383480B1
公开(公告)日：2002-05-07
申请号：US09214569
申请日：1999-01-07
IPC分类号： A61K3800
CPC分类号： C12N5/0647 , A61K35/28 , A61K38/18 , A61K38/193 , C12N2500/25 , C12N2501/10 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , Y10S514/885 , A61K2300/00
摘要： The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
摘要翻译： 本发明提供了单独使用作为增殖造血干细胞和造血前体细胞的药剂的MK家族的新用途。 本发明还提供了用于显着增强上述促进造血干细胞和造血前体细胞增殖的作用的药剂，其包含MK家族与已知造血因子如IL-3，IL-6，G-CSF的组合 ，GM-CSF，M-CSF，SCF和EPO。
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公开(公告)号：US5580713A
公开(公告)日：1996-12-03
申请号：US376446
申请日：1995-01-23
申请人： Takefumi Hara , Makoto Kikuchi , Hisashi Okamura
发明人： Takefumi Hara , Makoto Kikuchi , Hisashi Okamura
CPC分类号： G03C1/015 , G03C1/34 , G03C5/50 , G03C7/39296 , G03C7/305 , G03C7/3924
摘要： A silver halide color reversal photographic light-sensitive material includes at least one blue-sensitive silver halide emulsion layer, at least one green-sensitive silver halide emulsion layer, and at least one red-sensitive silver halide emulsion layer, formed on a support. At least one light sensitive emulsion layer contains silver halide grains having a silver halide phase formed in the presence of an iodide ion-releasing agent, under controlled release of iodide ions from the releasing agent. At least one hydrophilic colloid layer contains a certain heterocyclic compound or a certain DIR compound.
摘要翻译： 卤化银彩色反转照相感光材料包括形成在载体上的至少一种感蓝卤化银乳剂层，至少一种感绿卤化银乳剂层和至少一种感红卤化银乳剂层。 在碘离子释放剂的存在下，至少一种感光乳剂层含有卤化银颗粒，其在碘离子释放剂的存在下形成卤化银相。 至少一个亲水胶体层含有某种杂环化合物或某种DIR化合物。
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公开(公告)号：US5498516A
公开(公告)日：1996-03-12
申请号：US59667
申请日：1993-05-12
申请人： Makoto Kikuchi , Hisashi Okamura
发明人： Makoto Kikuchi , Hisashi Okamura
CPC分类号： G03C1/0051 , G03C1/10
摘要： A silver halide photographic light-sensitive material having a silver halide emulsion layer on a support, wherein said silver halide emulsion layer contains a silver halide emulsion in which silver halide tabular grains (fringe-dislocation tabular grains), which have an aspect ratio of 2 to 40 and in which dislocation lines are localized essentially to only fringe portions, occupy 100% to 80% of a total projected area of all grains.
摘要翻译： 一种在载体上具有卤化银乳剂层的卤化银照相感光材料，其中所述卤化银乳剂层含有卤化银乳剂，其中卤化银片状颗粒（条纹位错片状颗粒）的纵横比为2 至40，并且位错线基本上仅局限于边缘部分，占所有晶粒总投影面积的100％至80％。
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公开(公告)号：US5496694A
公开(公告)日：1996-03-05
申请号：US204659
申请日：1994-03-02
申请人： Makoto Kikuchi , Tetsuo Okutsu
发明人： Makoto Kikuchi , Tetsuo Okutsu
CPC分类号： G03C1/0051 , G03C1/07
摘要： A silver halide photographic light-sensitive material includes a support having provided thereon a silver halide emulsion layer containing a silver halide emulsion in which, when that a specific silver iodide content is I mol % (0.3
摘要翻译： 卤化银摄影感光材料包括其上设置有含有卤化银乳剂的卤化银乳剂层的载体，其中当特定碘化银含量为1mol％（0.3
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公开(公告)号：US5427714A
公开(公告)日：1995-06-27
申请号：US096848
申请日：1993-07-26
CPC分类号： C07D239/26 , C09K19/3463
摘要： A ferroelectric liquid crystal composition having a SC* phase and a light-switching element using the composition are provided, which composition comprises the following components, A, B and C, each in a specified proportion: Component A has the formula ##STR1## wherein ##STR2## R.sup.1 and R.sup.2 are same or different linear or branched alkyl, alkoxy or alkanoyloxy of 1-18C, X is H, halogen or CN, l, m and n are 0 or 1 and (l+m+n) is 1 or 2, and has smectic C phase;Component B has the formula ##STR3## wherein ##STR4## Y is H, halogen or CN, k is 0 or 1, R.sup.3 is linear or branched alkyl or alkoxy of 1-18C, and * is asymmetric C, and consists of optically active compounds having the same senses of Ps in SC* phase induced when dissolved in smectic C liquid crystal, to one another; andComponent C has the formula ##STR5## wherein ##STR6## Z is H, halogen or CN, R.sup.5 and R.sup.6 are same or different linear or branched alkyl or alkoxy of 1-18C R.sup.4 is 12-18C alkyl or 1-18C linear or branched alkoxy, and * is asymmetric C, and is an optically active compound having the same sense of Ps in SC* phase induced when dissolved in smectic C liquid crystal as that of the compound of component B.
摘要翻译： 提供具有SC *相的铁电液晶组合物和使用该组合物的光开关元件，该组成包含以下组分，A，B和C各自为特定比例：组分A具有式“IMAGE”（ A）其中R1和R2是1-18C的相同或不同的直链或支链烷基，烷氧基或烷酰氧基，X是H，卤素或CN，l，m和n是0或1，并且（1+ m + n）为1或2，具有近晶C相; 组分B具有式（B）其中
或CN，k为0或1，R3为1-18C的直链或支链烷基或烷氧基，*为不对称C，并由具有 在溶解在近晶C液晶中时，在SC *相中诱导的Ps的相同感觉; 并且组分C具有其中 的公式 （C） -
公开(公告)号：US5240638A
公开(公告)日：1993-08-31
申请号：US908854
申请日：1992-07-01
CPC分类号： C09K19/46 , C09K19/0225 , C09K19/3441
摘要： A ferroelectric liquid crystal composition comprising smectic liquid crystal composition(s) and optically active compounds and having a spontaneous polarization value of 20 nC cm.sup.-2 or less and nevertheless having high rate response properties, and a light-switching element are provided, which composition comprises the following components (A), (B), (C) and (D), in 76-95, 2-10, 1-6 and 2-8 wt.%, respectively, based on the total quantity of the 4 components:(A): at least one compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, being 1-18C alkyl, or the formula ##STR2## wherein R.sup.3 and R.sup.4 are the same or different, being 1-18C alkyl or alkoxy and having smectic C phase:(B): an optically active compound of the formula ##STR3## wherein R.sup.5 is 1-18C alkyl or alkoxy, X is ##STR4## Y is halogen or H and * is asymmetric C atom; (C): at least one optically active compound of the formulas ##STR5## wherein R.sup.6 and R.sup.8 are 1-18C alkyl or alkoxy, R.sup.7 and R.sup.9 are 2-18C alkyl or alkoxy and * is an asymmetric C atom; and(D): at least on optically active compound formula ##STR6## wherein R.sup.10 is 1-18 C alkyl or alkoxy, Z is H or halogen and * is an asymmetric C atom.
摘要翻译： 提供了包含近晶型液晶组合物和光学活性化合物并且具有20nC cm -2以下的自发极化值并且具有高速率响应特性的铁电液晶组合物和光开关元件，该组成 包括以下组分（A），（B），（C）和（D），分别为76-95，2-10,1-6和2-8重量％，基于4 组分：（A）：至少一种式（I）的化合物，其中R 1和R 2相同或不同，为1-18C烷基或式（II），其中R 3和R 4为 相同或不同的是1-18C烷基或烷氧基并具有近晶C相：（B）：下式的光学活性化合物其中R5是1-18C烷基或烷氧基，X是Y 是卤素或H，*是不对称C原子; （IV）2a或图像（IV）中的至少一种光学活性化合物（IV-1a）图像（IV-1b） （IV-2b）其中R6和R8为1-18C烷基或烷氧基，R7和R9为2-18C烷基或烷氧基，*为不对称C原子; 和（D）：至少在光学活性化合物式“IMAGE”，1CHC2H5 + RE（V）其中R10为1-18C烷基或烷氧基，Z为H或卤素，*为不对称C原子。
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公开(公告)号：US5231997A
公开(公告)日：1993-08-03
申请号：US662102
申请日：1991-02-28
IPC分类号： A61N5/02
CPC分类号： A61N5/02
摘要： A heating apparatus for hyperthermia utilizes electromagnetic waves for locally heating cancerous cells within a living body. Electromagnetic waves output from a single electromagnetic wave generating means are branched into a plurality of branched electromagnetic waves, which are respectively employed to conduct hyperthermia treatments for a plurality of patients. The whole of the hyperthermia system is controlled in a concentrated fashion from a single section by means of time-division multiplexing. It is therefore possible for a plurality of patients to be subjected to hyperthermia treatment at the same time and in parallel with each other, even when the conditions of these patients differ from one another. Further, it is advantageously possible to simplify the arrangement of the system as a whole and stabilize the control of the system.
摘要翻译： 用于热疗的加热装置利用电磁波来局部加热活体内的癌细胞。 从单个电磁波产生装置输出的电磁波被分支成多个分支电磁波，其分别用于对多个患者进行热疗治疗。 整个热疗系统通过时分复用从单个部分以集中的方式进行控制。 因此，即使这些患者的病情彼此不同，多个患者也可以同时进行热疗处理并且彼此并行。 此外，有利地可以简化整个系统的布置并稳定系统的控制。
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公开(公告)号：US5148814A
公开(公告)日：1992-09-22
申请号：US637627
申请日：1991-01-04
CPC分类号： A61N5/02
摘要： A heating apparatus for hyperthermia utilizes electromagnetic waves for locally heating cancerous cells within a living body. When it is necessary for a plurality of patients to be subjected to hyperthermia treatment at the same time and in parallel with each other, the control of a plurality of electromagnetic wave outputs and the control of cooling of the surface of a heated region are effected by a centralized control which employs time-division multiplexing. Thus, it is advantageously possible to efficiently carry out a hyperthermia treatment which is fitting for the condition of each of a plurality of patients.
摘要翻译： 用于热疗的加热装置利用电磁波来局部加热活体内的癌细胞。 当需要多个患者同时进行热疗处理并且彼此并行时，多个电磁波输出的控制和加热区域的表面的冷却控制是通过 采用时分复用的集中控制。 因此，有利地可以有效地进行适合于多个患者中的每一个的状况的高热治疗。
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