公开(公告)号：US11744639B2

公开(公告)日：2023-09-05

申请号：US16379140

申请日：2019-04-09

Applicant: Shifamed Holdings, LLC

Inventor： Amr Salahieh ,  Jonah Lepak ,  Emma Lepak ,  Brian D. Brandt ,  John P. Claude ,  TOm Saul

IPC: A61B18/12 ,  A61B18/14 ,  A61B5/00 ,  A61N1/05 ,  A61M25/01 ,  A61M25/10 ,  A61B1/00 ,  A61B1/06 ,  A61B5/287 ,  A61B18/00 ,  A61N5/02 ,  A61B5/01 ,  A61B18/18 ,  A61M25/04 ,  A61B17/00 ,  A61B17/22 ,  A61B18/02 ,  A61M25/06 ,  A61B90/00 ,  A61B34/20

CPC classification number: A61B18/1492 ,  A61B1/00082 ,  A61B1/00179 ,  A61B1/0623 ,  A61B5/287 ,  A61B5/6853 ,  A61B5/6858 ,  A61B18/1206 ,  A61M25/0147 ,  A61M25/1011 ,  A61N1/05 ,  A61B1/0684 ,  A61B5/01 ,  A61B5/6843 ,  A61B5/6855 ,  A61B18/1815 ,  A61B34/20 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00178 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/124 ,  A61B2018/126 ,  A61B2018/1405 ,  A61B2018/1465 ,  A61B2018/1467 ,  A61B2090/065 ,  A61B2090/3966 ,  A61B2217/007 ,  A61B2218/002 ,  A61B2218/007 ,  A61B2562/04 ,  A61B2562/125 ,  A61B2562/164 ,  A61M25/0108 ,  A61M25/0133 ,  A61M25/04 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/105 ,  A61M2025/1068 ,  A61N5/02 ,  C08L2201/12

Abstract: Cardiac tissue ablation catheters including an inflatable and flexible toroidal or spherically shaped balloon disposed at a distal region of an elongate member, a flexible circuit carried by an outer surface of the balloon, the flexible circuit including, a plurality of flexible branches conforming to the radially outer surface of the balloon, each of the plurality of flexible branches including a substrate, a conductive trace carried by the substrate, and an ablation electrode carried by the substrate, the ablation electrode in electrical communication with the conductive trace, and an elongate shaft comprising a guidewire lumen extending in the elongate member and extending from a proximal region of the inflatable balloon to distal region of the inflatable balloon and being disposed within the inflatable balloon, wherein a distal region of the elongate shaft is secured directly or indirectly to the distal region of the inflatable balloon.

公开(公告)号：US20180318006A1

公开(公告)日：2018-11-08

申请号：US16030309

申请日：2018-07-09

Applicant: Covidien LP

Inventor： Robert J. Behnke, II ,  Mani N. Prakash ,  Jeffrey L. Jensen ,  Francesca Rossetto ,  Joseph D. Brannan

IPC: A61B18/18 ,  A61N5/02 ,  A61B18/00

CPC classification number: A61B18/1815 ,  A61B2018/0019 ,  A61B2018/00577 ,  A61B2018/1823 ,  A61B2018/1869 ,  A61B2018/1884 ,  A61N5/02

Abstract: A microwave ablation system includes an energy source adapted to generate microwave energy and a power splitting device having an input adapted to connect to the energy source and a plurality of outputs. The plurality of outputs are configured to be coupled to a corresponding plurality of energy delivery devices. The power splitting device is configured to selectively divide energy provided from the energy source between the plurality of energy devices.

公开(公告)号：US20180296837A1

公开(公告)日：2018-10-18

申请号：US16014822

申请日：2018-06-21

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Shu XIAO ,  Andrei PAKHOMOV ,  Karl H. SCHOENBACH

IPC: A61N1/36 ,  A61N5/02 ,  A61N2/00 ,  A61N1/40

CPC classification number: A61N1/36014 ,  A61N1/40 ,  A61N2/006 ,  A61N5/02

Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.

公开(公告)号：US20180235694A1

公开(公告)日：2018-08-23

申请号：US15959767

申请日：2018-04-23

Applicant: Covidien LP

Inventor： Christopher T. Rusin ,  Darion Peterson ,  Tao D. Nguyen

IPC: A61B18/18 ,  A61N5/02 ,  A61B18/00

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61N5/02

Abstract: A microwave ablation device for treating tissue includes an inner conductor having a length and a distal end and configured to deliver energy, a wire extending adjacent the inner conductor and axially translatable relative thereto, the wire including a length and a distal end, a distal tip disposed in mechanical cooperation with the distal end of the inner conductor and the distal end of the wire, and an outer conductor including a distal end and defining a longitudinal axis, the outer conductor at least partially surrounding the inner conductor and the wire at least partially along their lengths. The distal tip is movable substantially along the longitudinal axis with respect to the outer conductor and relative movement of the distal tip towards the distal end of the outer conductor causes at least a portion of the inner conductor to move away from the longitudinal axis.

公开(公告)号：US20180110964A1

公开(公告)日：2018-04-26

申请号：US15848114

申请日：2017-12-20

Applicant: Ethicon, Inc.

Inventor： Kevin Weadock ,  Jeffrey Hammond

IPC: A61M25/01 ,  A61N5/10 ,  A61B1/04 ,  A61B1/06 ,  A61B17/34 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4375 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/38 ,  A61M25/06 ,  A61M25/09 ,  A61M31/00 ,  A61M37/00 ,  A61N1/05 ,  A61N1/20 ,  A61N5/02 ,  A61N5/00 ,  A61B6/12 ,  A61B10/02 ,  A61B1/015 ,  A61B18/00 ,  A61N1/32 ,  A61B5/055 ,  A61B5/00 ,  A61B8/08

CPC classification number: A61M25/0169 ,  A61B1/015 ,  A61B1/04 ,  A61B1/06 ,  A61B5/055 ,  A61B5/4839 ,  A61B6/12 ,  A61B8/085 ,  A61B10/0233 ,  A61B17/3415 ,  A61B17/3421 ,  A61B17/3468 ,  A61B90/361 ,  A61B90/39 ,  A61B2017/3445 ,  A61B2018/00005 ,  A61B2018/00273 ,  A61B2018/00601 ,  A61B2018/00613 ,  A61B2018/00982 ,  A61B2018/00994 ,  A61B2090/3908 ,  A61B2090/3987 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4375 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/385 ,  A61M25/06 ,  A61M25/09 ,  A61M31/00 ,  A61M31/002 ,  A61M31/007 ,  A61M37/0092 ,  A61M2025/0166 ,  A61M2025/09125 ,  A61M2025/09141 ,  A61M2025/09166 ,  A61M2025/09175 ,  A61N1/05 ,  A61N1/20 ,  A61N1/327 ,  A61N5/00 ,  A61N5/02 ,  A61N5/1001 ,  A61N5/1027

Abstract: Novel systems for and methods of delivering therapeutic agents to target tissues are disclosed. The method of delivering a therapeutic agent to a target tissue involves identifying a target tissue via an imaging modality and then using a guidewire capable of anchoring in tissue to advance a cannula to the target tissue. The guidewire and novel cannula configurations enable rapid and repeated treatments of the target tissue without the need for subsequent imaging. The cannula is coupled to a source of ultrasound, radiation, radiofrequency energy, or chemotherapeutic agents which can then be delivered to from the cannula the target tissue. The system and method can be used to treat tumors that are small or surgically inoperable. In addition, the system can be used to treat lymphatic tissue that may contain metastases from the tumors.

公开(公告)号：US20170245929A1

公开(公告)日：2017-08-31

申请号：US15288949

申请日：2016-10-07

Applicant: Mark E. DEEM ,  Daniel E. FRANCIS ,  Jessi Ernest JOHNSON ,  Steven W. KIM ,  Alexey SALAMINI

Inventor： Mark E. DEEM ,  Daniel E. FRANCIS ,  Jessi Ernest JOHNSON ,  Steven W. KIM ,  Alexey SALAMINI

IPC: A61B18/18 ,  A61B34/10 ,  A61N5/02

CPC classification number: A61B18/1815 ,  A61B18/18 ,  A61B34/10 ,  A61B90/37 ,  A61B2018/00005 ,  A61B2018/00017 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00041 ,  A61B2018/00452 ,  A61B2034/104 ,  A61N5/02 ,  A61N5/025 ,  A61N2005/007

Abstract: Methods, apparatuses and systems are provided for non-invasive delivery of microwave therapy. Microwave energy may be applied to epidermal, dermal and subdermal tissue of a patient to achieve various therapeutic and/or aesthetic results. In one embodiment, the microwave energy is applied to a target tissue via an energy delivery applicator connected to an energy generator. The energy delivery applicator may comprise one or more antennas, including monopole, dipole, slot and/or waveguide antennas (among others) that are used to direct the microwave energy to the target tissue. The energy delivery applicator may also comprise a cooling element for avoiding thermal destruction to non-target tissue and/or a suction device to localize thermal treatment at specific portions of a skin fold.

公开(公告)号：US20170239489A1

公开(公告)日：2017-08-24

申请号：US15504917

申请日：2015-08-17

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. BOURKE, Jr. ,  Zakaryae FATHI ,  Harold WALDER

IPC: A61N5/06 ,  A61N5/02 ,  A61N1/40 ,  A61N5/10

CPC classification number: A61N5/062 ,  A61B18/18 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61N1/40 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0616 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/0625 ,  A61N5/10 ,  A61N2005/0612 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0663 ,  A61N2005/067 ,  A61N2005/1089 ,  B82Y30/00

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

公开(公告)号：US20170135762A1

公开(公告)日：2017-05-18

申请号：US15418834

申请日：2017-01-30

Applicant: COVIDIEN LP

Inventor： Robert J. Behnke, II ,  Mani N. Prakash ,  Jeffrey L. Jensen ,  Francesca Rossetto ,  Joseph D. Brannan

IPC: A61B18/18

CPC classification number: A61B18/1815 ,  A61B2018/0019 ,  A61B2018/00577 ,  A61B2018/1823 ,  A61B2018/1869 ,  A61B2018/1884 ,  A61N5/02

Abstract: A microwave ablation system includes an energy source adapted to generate microwave energy and a power splitting device having an input adapted to connect to the energy source and a plurality of outputs. The plurality of outputs are configured to be coupled to a corresponding plurality of energy delivery devices. The power splitting device is configured to selectively divide energy provided from the energy source between the plurality of energy devices.

公开(公告)号：US09623224B2

公开(公告)日：2017-04-18

申请号：US14216522

申请日：2014-03-17

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Richard Daniel John Coulthard

IPC: A61M27/00 ,  A61M35/00 ,  A61N5/06 ,  A61F13/00 ,  A61M1/00 ,  A61N5/02 ,  A61K41/00

CPC classification number: A61M35/00 ,  A61F13/00068 ,  A61K41/00 ,  A61K41/0047 ,  A61L15/18 ,  A61L15/44 ,  A61L15/64 ,  A61L2300/418 ,  A61M1/0058 ,  A61M1/0084 ,  A61M1/0088 ,  A61M2202/0241 ,  A61M2202/0468 ,  A61N5/02 ,  A61N5/062

Abstract: Systems and methods of stimulating or activating fluids for use in wound treatment systems.

公开(公告)号：US09610006B2

公开(公告)日：2017-04-04

申请号：US13943633

申请日：2013-07-16

Applicant: Shifamed Holdings, LLC

Inventor： Amr Salahieh ,  Jonah Lepak ,  Emma Leung ,  Brian D. Brandt ,  John P. Claude ,  Tom Saul

IPC: A61B1/05 ,  A61B5/01 ,  A61B5/042 ,  A61B5/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61M25/01 ,  A61M25/04 ,  A61M25/06 ,  A61M25/10 ,  A61N1/05 ,  A61N5/02 ,  A61B1/06 ,  A61B18/02 ,  A61B90/00

CPC classification number: A61B1/05 ,  A61B1/06 ,  A61B5/01 ,  A61B5/0422 ,  A61B5/6853 ,  A61B5/6855 ,  A61B5/6858 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/124 ,  A61B2018/1465 ,  A61B2090/065 ,  A61B2090/3966 ,  A61B2217/007 ,  A61B2562/125 ,  A61B2562/164 ,  A61M25/0108 ,  A61M25/0133 ,  A61M25/0147 ,  A61M25/04 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0681 ,  A61N1/05 ,  A61N5/02 ,  C08L2201/12

Abstract: A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.