公开(公告)号：US20220323467A1

公开(公告)日：2022-10-13

申请号：US17642566

申请日：2020-10-06

申请人： University of South Florida

发明人： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Rinku Dutta ,  Waise Quarni

IPC分类号： A61K31/704 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04

摘要： The present application is directed to pharmaceutical combinations comprising mithramycin and immunotherapy to target cancer initiating stem cells (CSCs). The present application also discloses methods of treating cancer comprising administering mithramycin and immunotherapy to a subject in need thereof.

公开(公告)号：US20220315832A1

公开(公告)日：2022-10-06

申请号：US17838450

申请日：2022-06-13

申请人： University of South Florida

发明人： Manoj Kumar RAM ,  Elias K. STEFANAKOS

IPC分类号： C09K9/02 ,  B01J13/06 ,  B01J19/12 ,  C04B14/36 ,  C04B16/00 ,  C04B20/10 ,  C04B26/02 ,  C04B28/04

摘要： A variety of particles forming microencapsulated thermochromic materials. The particles can include a thermochromic core and a metal oxide shell encapsulating the thermochromic core. The thermochromic core can include one or both of an organic thermochromic material and an inorganic salt thermochromic material. In some aspects, the particles include a dye selected from a crystal violet lactone dye, a fluoran dye, and a combination thereof. In still further aspects, the particles include a color developer selected from a hydroxybenzoate, a 4,4′-dihydroxydiphenyl propane, a hydroxycoumarin derivative, a lauryl gallate, and a combination thereof. In some aspects, the metal oxide shell is a TiO2 shell. The particles can be used in cements and paints and for a variety of building materials. Methods of making the particles and building materials and methods of use, for example, for removing a volatile organic carbon from a building material, are also provided.

公开(公告)号：US20220288780A1

公开(公告)日：2022-09-15

申请号：US17689534

申请日：2022-03-08

申请人： University of South Florida

发明人： Lei Wu ,  Redwan Alqasemi ,  Rajiv Dubey

IPC分类号： B25J9/16 ,  B25J9/02

摘要： Disclosed is an intuitive robotic device control reference frame with hybrid inverse kinematics having a natural and easier human-robot interface. A system for controlling a robot can include a robotic device that performs tasks, an input device that receives user input indicating desired movement of the robotic device to perform the tasks, and a controller that controls the robotic device based on the user input. The controller can receive signals identifying the user input, determine a ground reference frame and an end-effector reference frame for controlling movement of the robotic device, generate, based on the ground reference frame and the end-effector reference frame, an intuitive reference frame for controlling movement of the robotic device, determine controls to move the robotic device in the intuitive reference frame, generate instructions for controlling movement of the robotic device, and execute the instructions to control movement of the robotic device.

公开(公告)号：US11439944B2

公开(公告)日：2022-09-13

申请号：US16584130

申请日：2019-09-26

申请人： University of South Florida ,  King Abdullah University of Science and Technology

发明人： Mohamed Eddaoudi ,  Michael J. Zaworotko ,  Patrick Nugent ,  Stephen Burd ,  Ryan Luebke ,  Youssef Belmabkhout ,  Osama Shekhah

IPC分类号： B01D53/02 ,  B01D53/04 ,  B01J20/22 ,  B01J20/28

摘要： Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO2 from a gas, and the like.

公开(公告)号：US20220280613A1

公开(公告)日：2022-09-08

申请号：US17626205

申请日：2020-07-10

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Chuanhai Cao

IPC分类号： A61K38/28 ,  A61K31/352 ,  A61K31/4045 ,  A61P25/28 ,  A61K9/107 ,  A61K47/24 ,  A61K47/10 ,  A61K47/14

摘要： The present application relates to compositions comprising (i) THC; (ii) melatonin; and (iii) insulin and methods of using same to Alzheimer's disease in a subject in need thereof without the psychological impairment and side effects associated with THC.

公开(公告)号：US20220273756A1

公开(公告)日：2022-09-01

申请号：US17742640

申请日：2022-05-12

申请人： University of South Florida

发明人： Bill J. Baker ,  Nerida G. Wilson ,  John H. Adams ,  Matthew A. Knestrick ,  Alison Elizabeth Roth

IPC分类号： A61K38/08 ,  A61P33/06 ,  A61K31/4706

摘要： Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.

公开(公告)号：US20220267361A1

公开(公告)日：2022-08-25

申请号：US17636717

申请日：2020-08-20

申请人： Yanming ZHAO ,  University of South Florida

发明人： Shengqian MA ,  Yanming ZHAO

IPC分类号： C07F15/02 ,  B01J31/16

摘要： Described herein are corrole-based frameworks and methods for making the same. The corrole-based frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses such as in gas storage/separation, proton conduction, biomedicine, sensing, and catalysis. In one aspect, the corrole-based frameworks are organic frameworks. In other aspects, the corrole-based frameworks are metal-organic frameworks.

公开(公告)号：US20220267270A1

公开(公告)日：2022-08-25

申请号：US17637773

申请日：2020-08-31

申请人： University of South Florida

发明人： Wayne Charles Guida ,  Kenyon Gregory Daniel ,  Wesley Harrell Brooks ,  Linette Harding ,  Rainer Scott Metcalf ,  Sam G. Shrivastava ,  James William Leahy ,  Robert Sparks

IPC分类号： C07D213/80

摘要： The present disclosure is directed to compounds of Formula (I), or pharmaceutically acceptable salts thereof and compounds of Formula (II), or pharmaceutically acceptable salts thereof, that modulate stimulator of interferon genes (STING), compositions comprising such compounds, and methods of using same for the treatment of disorders such as cancer and autoimmune disease.

公开(公告)号：US20220265598A1

公开(公告)日：2022-08-25

申请号：US16738351

申请日：2020-01-09

申请人： University of South Florida

发明人： Chuanhai Cao

IPC分类号： A61K31/352 ,  A61P25/28

摘要： Alzheimer's disease is treated using THC (alone, or in combination with melatonin) administered in an ultra-low dose amount sufficient to (i) reduce Aβ protein levels; (ii) reduce Aβ aggregation: (iii) maintain AβPP protein levels; (iv) enhance mitochondrial functioning; (v) decrease phosphorylation of GSK-3β protein; (vi) decrease GSK-3β protein levels; (vii) decrease phosphorylation of Tau protein; and/or (viii) maintain Tau protein levels, in said patient without severe psychological impairments and side effects associated with higher doses of THC.

公开(公告)号：US11414455B2

公开(公告)日：2022-08-16

申请号：US17063158

申请日：2020-10-05

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF SOUTH FLORIDA

发明人： David L. Morse ,  Josef Vagner ,  Mark McLaughlin ,  Robert Gillies ,  Amanda Huynh ,  Michael Doligalski

IPC分类号： A61K49/00 ,  A61K51/04 ,  C07K5/083

摘要： Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.