公开(公告)号：US11802267B2

公开(公告)日：2023-10-31

申请号：US17746149

申请日：2022-05-17

申请人： University of South Florida

发明人： John H. Adams ,  Alison Elizabeth Roth

IPC分类号： A61K38/08 ,  C12N5/07 ,  A01N1/02 ,  C12N5/00

CPC分类号： C12N5/0601 ,  A01N1/0221 ,  C12N5/0018

摘要： Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.

公开(公告)号：US11331367B1

公开(公告)日：2022-05-17

申请号：US16725182

申请日：2019-12-23

申请人： University of South Florida

发明人： Bill J. Baker ,  Nerida G. Wilson ,  John H. Adams ,  Matthew A. Knestrick ,  Alison Elizabeth Roth

IPC分类号： A61K38/08 ,  A61P33/06 ,  A61K31/4706

摘要： Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.

公开(公告)号：US20220273756A1

公开(公告)日：2022-09-01

申请号：US17742640

申请日：2022-05-12

申请人： University of South Florida

发明人： Bill J. Baker ,  Nerida G. Wilson ,  John H. Adams ,  Matthew A. Knestrick ,  Alison Elizabeth Roth

IPC分类号： A61K38/08 ,  A61P33/06 ,  A61K31/4706

摘要： Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.

公开(公告)号：US11332711B1

公开(公告)日：2022-05-17

申请号：US16376975

申请日：2019-04-05

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： John H. Adams ,  Alison Elizabeth Roth

IPC分类号： A61K38/08 ,  C12N5/07 ,  A01N1/02 ,  C12N5/00

摘要： Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.