公开(公告)号：US10765514B2

公开(公告)日：2020-09-08

申请号：US15782687

申请日：2017-10-12

Applicant: Valtech Cardio, Ltd.

Inventor： Ehud Iflah ,  Tal Reich ,  Tal Sheps ,  Ilia Hariton ,  Haim Brauon ,  Meir Kutzik ,  Alexei Koifman ,  Yaron Herman

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/068 ,  A61B17/00 ,  A61B17/064 ,  A61B90/00

Abstract: Apparatus is provided including a percutaneously-implantable implant and an adjustment device. The adjustment device can comprise an adjustment mechanism, coupled to the implant, and configured to change a dimension of the implant upon actuation of the adjustment mechanism and a lock. The adjustment device can have a locked state in which the lock inhibits actuation of the adjustment mechanism and an unlocked state in which the adjustment mechanism is actuatable. The adjustment device can be reversibly movable between the locked state and the unlocked state. The apparatus can include a longitudinal guide member and an adapter. An unlocking mechanism can be configured such that, while the adapter is coupled to the adjustment device, actuation of the unlocking mechanism moves the lock between the locked state and the unlocked state. Other applications are also described.

公开(公告)号：US10751184B2

公开(公告)日：2020-08-25

申请号：US15970743

申请日：2018-05-03

Applicant: Valtech Cardio, Ltd.

Inventor： Tal Reich ,  Eran Miller ,  Tal Sheps

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/00

Abstract: A tissue-engaging element has a distal portion configured to engage a portion of tissue of the heart. A guide member is reversibly coupled to the tissue-engaging element. An artificial chorda tendinea has a distal end and a proximal end, at least the distal end being slidably coupled to the guide member. A tool is slidable along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the chorda tendinea, and (ii) the guide member is coupled to the tissue-engaging element, such that sliding of the tool along the guide member distally toward the tissue-engaging element while (i) the tool is coupled to at least the distal end of the chorda tendinea, and (ii) the guide member is coupled to the tissue-engaging element, slides at least the distal end of the chorda tendinea toward the tissue-engaging element.

公开(公告)号：US10470882B2

公开(公告)日：2019-11-12

申请号：US15474543

申请日：2017-03-30

Applicant: VALTECH CARDIO, LTD.

Inventor： Amir Gross ,  Tal Sheps ,  Tal Hammer ,  Tal Reich ,  Ehud Iflah ,  Yaron Herman ,  Uriel Aba Pomerantz ,  Oz Cabiri

IPC: A61F2/24 ,  A61B17/068 ,  A61B17/072 ,  A61B17/04 ,  A61B17/00 ,  A61B17/064

Abstract: During a percutaneous procedure, a flexible sleeve of an annuloplasty structure is introduced into an atrium and arranged completely around an annulus as a closed loop, such that none of one or more longitudinal contracting members thereof is positioned along an anterior portion of the annulus between fibrous trigones of the valve. The annuloplasty structure is fastened to the annulus. At least a portion of a posterior portion of the annulus is tightened, while preserving a length of an anterior portion of the annulus between fibrous trigones of the valve, by contracting, using the one or more longitudinal contracting members, a longitudinal portion of the sleeve not positioned along the anterior portion of the annulus between the fibrous trigones of the valve. Thereafter, the one or more longitudinal contracting members are locked.

公开(公告)号：US10376266B2

公开(公告)日：2019-08-13

申请号：US14437062

申请日：2013-10-23

Applicant: VALTECH CARDIO, LTD.

Inventor： Yaron Herman ,  Yuval Zipory ,  Slava Starobinsky ,  Tal Reich ,  Ehud Iflah ,  Alexei Koifman

IPC: A61B17/12 ,  A61B17/04 ,  A61F2/24 ,  A61B17/00 ,  A61B17/29

Abstract: A first element (91) includes a first arm (92) and a second arm coupled thereto and having a concavity (103) facing the first arm and defining a space (96). In an open state, a tissue anchor portion (46) moves into the space through a gap between distal portions (94) of the first and second arms. In the closed state, the anchor portion is not movable through the gap. A second element (82) is movable with respect to the first element, such that, while the portion (46) of the anchor (40) is within the space, and the first element is in the closed state, in a first position of the second element, the portion of the anchor is movable within the space, and in a second position of the second element, the second element applies torque to the anchor by rotating the second element. Other embodiments are also described.

公开(公告)号：US10299793B2

公开(公告)日：2019-05-28

申请号：US15030731

申请日：2014-10-21

Applicant: VALTECH CARDIO, LTD.

Inventor： Yuval Zipory ,  Alexei Koifman ,  Ehud Iflah ,  Tal Reich

IPC: A61B17/10 ,  A61B17/068 ,  A61B50/20 ,  A61B50/30 ,  A61B17/00 ,  A61B17/04 ,  A61B17/064

Abstract: Apparatus is provided, the apparatus comprising (i) a housing (22, 222), shaped to define a channel (24, 224) having an anchor-storage zone (26, 226) and an opening (28, 228) configured to provide access for an anchor driver (60) to the anchor-storage zone; (ii) a tissue anchor (40), stored in the anchor-storage zone and slidable through the channel; and (iii) a retaining member (30, 230). The retaining member (a) has a retaining state in which the retaining member is configured to retain the tissue anchor in the anchor-storage zone, and (b) is configured, by moving in response to a proximally-directed force applied to the tissue anchor, to allow the tissue anchor to leave the anchor-storage zone in response to the proximally-directed force. The proximally-directed force is greater than a pre-determined threshold force. Other embodiments are described.

公开(公告)号：US20180116797A9

公开(公告)日：2018-05-03

申请号：US15208253

申请日：2016-07-12

Applicant: Eran MILLER ,  Oz CABIRI

Inventor： Eran MILLER ,  Oz CABIRI

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2220/0016

Abstract: An apparatus including an implant configured to be coupled to cardiac tissue of a patient, the implant including a sleeve; a spool coupled to the implant; a flexible contracting member coupled to the spool and the sleeve such that winding the contracting member around the spool tightens the contracting member; and a tissue anchor including a distal tissue coupling element configured to couple the tissue anchor to the cardiac tissue of the patient; and a proximal implant-receiving element configured to receive at least a portion of the implant and facilitate coupling of the implant to the tissue anchor; and a proximal implant-receiving element including an implant-restraining element coupled to a portion of the implant-receiving element, the implant-restraining element being configured to restrain the implant from separating from the implant-receiving element.

公开(公告)号：US20170196691A1

公开(公告)日：2017-07-13

申请号：US15444862

申请日：2017-02-28

Applicant: VALTECH CARDIO, LTD.

Inventor： Yuval ZIPORY ,  Tal HAMMER

IPC: A61F2/24 ,  A61B17/064

CPC classification number: A61F2/2445 ,  A61B17/064 ,  A61B17/068 ,  A61B90/30 ,  A61B2017/0649 ,  A61B2090/306 ,  A61B2090/309 ,  A61F2/2466 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method is provided including introducing into a heart atrium, an annuloplasty structure having a sleeve with an elongated tubular side wall, anchoring a first section of the sleeve by deploying a first tissue anchor through the first section and into a first portion of annulus tissue, and anchoring a second section of the sleeve by deploying a second tissue anchor through the second section and into a second portion of annulus tissue. A longitudinal portion of the tubular side wall is disposed between the first and second tissue anchors and has first and second lateral parts. The first lateral part is closer to the annulus than the second lateral part is to the annulus, and the second lateral part is opposite the first lateral part and has a larger degree of tension than a degree of tension of the first lateral part.

公开(公告)号：US09636224B2

公开(公告)日：2017-05-02

申请号：US13319030

申请日：2010-05-04

Applicant: Yuval Zipory ,  Oz Cabiri ,  Tal Hammer ,  Aram Ayvazian

Inventor： Yuval Zipory ,  Oz Cabiri ,  Tal Hammer ,  Aram Ayvazian

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/00 ,  A61B17/12 ,  A61B17/29 ,  A61F2/30

CPC classification number: A61F2/2436 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61B2017/2923 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2002/30537 ,  A61F2220/0016 ,  A61F2250/0004

Abstract: Apparatus is provided for use with a subject, including an implant comprising a sleeve shaped so as to define a lumen therein, the sleeve having first and second portions. A contracting mechanism is coupled to a portion of an outer surface of the sleeve in a vicinity of the first portion of the sleeve. An elongated contracting member is coupled at a first end portion thereof to the contracting mechanism, and coupled at a second end portion thereof to the sleeve in a vicinity of the second portion of the sleeve. The contracting mechanism comprises a driving interface that is positioned so as to be accessible from the portion of the outer surface of the sleeve. The contracting mechanism is configured such that rotation of the driving interface contracts the implant by tightening the elongated contracting member. Other applications are also described.

公开(公告)号：US09474606B2

公开(公告)日：2016-10-25

申请号：US14027934

申请日：2013-09-16

Applicant: VALTECH CARDIO, LTD.

Inventor： Yuval Zipory ,  Tal Hammer ,  Amir Gross ,  Oz Cabiri ,  Eran Miller

IPC: A61F2/24 ,  A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072

CPC classification number: A61F2/2436 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61B2017/2923 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2002/30537 ,  A61F2220/0016 ,  A61F2250/0004

Abstract: Apparatus is provided that includes an implant structure, which includes a contracting mechanism, which includes a rotatable structure, arranged such that rotation of the rotatable structure contracts the implant structure. A longitudinal member is coupled to the contracting mechanism. A tool for rotating the rotatable structure is configured to be guided along the longitudinal member, to engage the rotatable structure, and to rotate the rotatable structure in response to a rotational force applied to the tool. Other embodiments are also described.

Abstract translation: 提供了包括植入物结构的装置，其包括收缩机构，该收缩机构包括可旋转结构，其布置成使得可旋转结构的旋转使植入物结构收缩。 纵向构件联接到收缩机构。 用于旋转可旋转结构的工具被配置为沿着纵向构件被引导以接合可旋转结构，并且响应于施加到工具的旋转力而旋转可旋转结构。 还描述了其它实施例。

公开(公告)号：US20160113767A1

公开(公告)日：2016-04-28

申请号：US14990172

申请日：2016-01-07

Applicant: VALTECH CARDIO, LTD.

Inventor： Eran MILLER ,  Tal REICH ,  Amir GROSS ,  Tal SHEPS ,  Oz CABIRI

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2448 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2250/001

Abstract: Apparatus includes an annuloplasty structure, including: (i) a tubular body portion that is configured to be disposed at an annulus of a valve of a heart, and is shaped to define a perimeter; (ii) a flexible member, disposed within the tubular body portion; (iii) a first adjustment mechanism, attached to the tubular body portion and to the flexible member such that reversible actuation of the first adjustment mechanism reversibly adjusts a first dimension of the body portion by adjusting tension of the flexible member; (iv) a second adjustment mechanism, coupled to the tubular body portion, and reversibly actuatable to reversibly adjust a second dimension of the body portion. The apparatus further includes one or more elongate tools, reversibly couplable to the first and second adjustment mechanisms, and configured to independently actuate the first and second adjustment mechanisms by applying force thereto while the heart is beating.

Abstract translation: 装置包括瓣膜成形术结构，包括：（i）管状主体部分，其构造成设置在心脏瓣膜的环形处，并且被成形为限定周界; （ii）设置在所述管状主体部分内的柔性构件; （iii）第一调节机构，附接到管状主体部分和柔性构件，使得第一调节机构的可逆致动可通过调整柔性构件的张力来可逆地调节主体部分的第一尺寸; （iv）耦合到所述管状主体部分的第二调节机构，并且可逆地致动以可逆地调节所述主体部分的第二尺寸。 该装置还包括一个或多个细长工具，其可逆地联接到第一和第二调节机构，并且构造成通过在心脏跳动时施加力来独立地致动第一和第二调节机构。