公开(公告)号：US20030130544A1

公开(公告)日：2003-07-10

申请号：US10287731

申请日：2002-11-04

Inventor： Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

IPC: C07C001/20 ,  C07C002/86 ,  C07C041/05 ,  C07C029/04

CPC classification number: B01J31/248 ,  B01J23/44 ,  B01J31/1895 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/36 ,  C07C2/406 ,  C07C41/06 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07F9/65683 ,  C07C255/19 ,  C07C11/12 ,  C07C43/15

Abstract: Process for the telomerization of a conjugated diene, wherein the conjugated diene is reacted with a compound containing an active hydrogen atom and having a formula RnullnullH in the presence of a telomerization catalyst based on: (a) a source of group VIII metal, (b) a bidentate ligand wherein the bidentate ligand has the general formula I R1R2M1nullRnullM2R3R4 nullnull(I) wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent a monovalent aliphatic group; or R1, R2 and M1 together and/or R3, R4 and M2 together independently represent an optionally substituted aliphatic cyclic group with at least 5 ring atoms, of which one is the M1 or M2 atom, respectively; R represents a bivalent organic bridging group; and novel bidentate diphosphines which can be used in this process.

Abstract translation: 共轭二烯的调聚方法，其中在调聚催化剂的存在下，共轭二烯与含有活性氢原子的化合物反应并具有式R'-H，其基于：（a）VIII族金属源 ，（b）双齿配体，其中二齿配体具有通式I R 1 R 2 M 1 -R-M 2 R 3 R 4（I），其中M1和M2独立地为P，As或Sb; R1，R2，R3和R4独立地表示一价脂族基团; 或R 1，R 2和M 1一起和/或R 3，R 4和M 2一起独立地表示任选取代的具有至少5个环原子的脂族环基，其中一个是分别为M1或M2原子; R表示二价有机桥基; 和可用于该方法的新型二齿二膦。

公开(公告)号：US20030125546A1

公开(公告)日：2003-07-03

申请号：US10258942

申请日：2002-10-29

Inventor： Peter Bassler ,  Dieter Baumann ,  Rolf-Hartmuth Fischer ,  Eberhard Fuchs ,  Johann-Peter Melder ,  Frank Ohlbach

IPC: C07D201/02

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: A process for the preparation of caprolactam is provided, wherein a) a mixture (I) containing 6-aminocapronitrile and water is reacted in the liquid phase, in the presence of a catalyst, to give a mixture (II) containing caprolactam, ammonia, water, high-boiling components and low-boiling components, b) ammonia is then removed from the mixture (II) to give a mixture (III) containing caprolactam, water, high-boiling components and low-boiling components, c) water is then removed from the mixture (III) to give a mixture (IV) containing caprolactam, high-boiling components and low-boiling components, and d) a solid (V) containing caprolactam is then obtained from the mixture (IV) by crystallization, the proportion by weight of caprolactam in the solid (V) being greater than in the mixture (IV).

Abstract translation: 提供了制备己内酰胺的方法，其中a）含有6-氨基己腈和水的混合物（I）在液相中在催化剂存在下反应，得到含有己内酰胺，氨， 水，高沸点组分和低沸点组分，b）然后从混合物（II）中除去氨，得到含有己内酰胺，水，高沸点组分和低沸点组分的混合物（III），c）水是 然后从混合物（III）中取出，得到含己内酰胺，高沸点成分和低沸点组分的混合物（Ⅳ），然后通过结晶从混合物（Ⅳ）中获得含有己内酰胺的固体（Ⅴ） 固体（V）中己内酰胺的重量比例大于混合物（IV）中的比例。

公开(公告)号：US20030125544A1

公开(公告)日：2003-07-03

申请号：US10258943

申请日：2002-10-29

Inventor： Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf-Hartmuth Fischer ,  Hermann Luyken ,  Stefan Maixner ,  Johann-Peter Melder

IPC: C07D21/08 ,  C07D25/08 ,  C07D27/26 ,  C07D211/40

CPC classification number: C07D201/08

Abstract: A process is provided for the preparation of cyclic lactams of formula (II): 1 in which n and m can each have the values 0, 1, 2, 3, 4, 5, 6, 7, 8 and 9 and the sum of nnullm is at least 3, preferably at least 4, and R1 and R2 are C1-C6-alkyl, C5-C7-cycloalkyl or C6-C12-aryl groups, by reacting a compound (I) of the formula 2 in which R1, R2, m and n are as defined above and R are nullsicnull nitrile, carboxamide and carboxylic acid groups, with steam in the gas phase, wherein a) the compound (I) is reacted with steam in the gas phase with the addition, before or after the reaction, of an organic diluent (III) which exhibits a miscibility gap with water under specific quantity, pressure and temperature conditions, to give a mixture (IV) containing a lactam (II), b) the mixture (IV) is converted, before or after the separation of ammonia, under quantity, pressure and temperature conditions such that the diluent (III) and water are liquid and exhibit a miscibility gap, to give a two-phase system consisting of a phase (V) containing a higher proportion of diluent (III) than water, and a phase (VI) containing a higher proportion of water than diluent (III), c) the phase (V) is separated from the phase (VI), and d) the diluent (III) and optionally by-products selected from the group consisting of low-boiling component nullsicnull, high-boiling component nullsicnull and unreacted compound (I) are separated from the phase (V) to give a lactam (II).

Abstract translation: 提供了制备式（II）的环状内酰胺的方法：其中n和m各自可以具有0,1,2,3,4,5,6,7,8和9以及n + m为至少3，优选至少4，并且R 1和R 2为C 1 -C 6 - 烷基，C 5 -C 7 - 环烷基或C 6 -C 12 - 芳基，其中R 1， R2，m和n如上所定义，R是具有气相中蒸汽的[sic]腈，甲酰胺和羧酸基团，其中a）化合物（I）与气相中的蒸汽反应， 在反应之前或之后，在特定量，压力和温度条件下与水显示出混溶性间隙的有机稀释剂（III），得到含有内酰胺（II）的混合物（IV），b）混合物（IV） 在数量，压力和温度条件下，在氨分离之前或之后转化，使得稀释剂（III）和水是液体并且表现出混溶性间隙，以产生两相系统的缺点 含有比水更高比例的稀释剂（III）的相（V）的沉淀，以及含有比稀释剂（III）更高比例的水的相（VI），c）将相（V）从相（ VI）和d）稀释剂（III）和任选的选自低沸点组分[sic]，高沸点组分[sic]和未反应化合物（I）的副产物与相（V ），得到内酰胺（II）。

公开(公告)号：US06562965B1

公开(公告)日：2003-05-13

申请号：US09610819

申请日：2000-07-06

Applicant: Jiacheng Zhou ,  Lynette May Oh ,  Philip Ma

Inventor： Jiacheng Zhou ,  Lynette May Oh ,  Philip Ma

IPC: C07D295033

CPC classification number: C07D261/10 ,  C07C253/00 ,  C07C255/41 ,  C07D201/08 ,  C07D261/08 ,  Y10S977/915 ,  C07C255/17 ,  C07C255/40

Abstract: The present invention relates to processes for the production of &agr;-aryl-&bgr;-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

Abstract translation: 本发明涉及制备α-芳基-β-酮腈的方法，其用作制备一系列重要生物学分子如促肾上腺皮质激素释放因子（CRF）受体拮抗剂的合成中间体。

公开(公告)号：US06392037B1

公开(公告)日：2002-05-21

申请号：US09925730

申请日：2001-08-10

Applicant: Frank P. W. Agterberg ,  Nicolaas F. Haasen ,  Rudolf P. M. Guit

Inventor： Frank P. W. Agterberg ,  Nicolaas F. Haasen ,  Rudolf P. M. Guit

IPC: C07D20108

CPC classification number: C07D201/08

Abstract: Process for the preparation of &egr;-caprolactam comprising treating 6-aminocaproic acid 6-aminocaproate ester, 6-aminocaproamide, oligomers or polymers of these compounds or mixtures comprising at least two of these compounds in a cyclisation reactor in the presence of superheated steam in which a gaseous product stream comprising &egr;-caprolactam, lights and heavies is obtained, wherein the product stream, after condensation and at least partial removal of water and lights, is split into a &egr;-caprolactam stream and a heavies stream containing heavies and &egr;-caprolactam and the heavies stream is recycled to a cyclisation reactor.

Abstract translation: 制备ε-己内酰胺的方法，包括在过热蒸汽存在下，在环化反应器中处理6-氨基己酸6-氨基己酸酯，6-氨基己酰胺，这些化合物的低聚物或包含至少两种这些化合物的混合物或其混合物，其中 得到包含ε-己内酰胺，光和重质物的气态产物流，其中在冷凝和至少部分除去水和光之后，产物流被分裂成ε-己内酰胺流和含有重质和ε-己内酰胺的重质流 并将重质物流再循环至环化反应器。

公开(公告)号：US06350883B1

公开(公告)日：2002-02-26

申请号：US09721285

申请日：2000-11-22

Applicant: Shien-Chang Chen ,  Fu-Shen Lin ,  Liang-An Hsu ,  Cheng-Lin Tsai ,  Joe-Min Lin

Inventor： Shien-Chang Chen ,  Fu-Shen Lin ,  Liang-An Hsu ,  Cheng-Lin Tsai ,  Joe-Min Lin

IPC: C07D207267

CPC classification number: C07D207/267 ,  C07D201/08

Abstract: The present invention is related to a method for preparing lactam represented by the following formula: wherein R is C2-10 alkylene which may be optionally substituted with C1-6 alkyl or phenyl; R′ is a hydrogen atom, C1-6 alkyl, C1-6 hydroxyalkyl or phenyl. The method for preparing lactam comprises an amination reaction using crystalline aluminosilicate zeolites as catalysts under the condition of gas phase in the presence of (a) lactone, (b) amine and/or ammonia and (c) water.

Abstract translation: 本发明涉及一种由下式表示的制备内酰胺的方法：其中R是可被C1-6烷基或苯基任意取代的C 2-10亚烷基; R'是氢原子，C 1-6烷基，C 1-6羟基烷基或苯基。 制备内酰胺的方法包括在（a）内酯，（b）胺和/或氨和（c）水的存在下，在气相条件下使用结晶硅铝酸盐沸石作为催化剂的胺化反应。

公开(公告)号：US5977356A

公开(公告)日：1999-11-02

申请号：US887174

申请日：1997-07-02

Applicant: Shiao-Jung Chu ,  Hsi-Yen Hsu ,  Ching-Tang Lin ,  Kwang-Chic Lai ,  J. H. Tsai

Inventor： Shiao-Jung Chu ,  Hsi-Yen Hsu ,  Ching-Tang Lin ,  Kwang-Chic Lai ,  J. H. Tsai

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: A simple and single step process for producing caprolactam comprising reacting 5-formylvaleric acid or an ester thereof in a solvent of water and/or an alcohol with hydrogen and ammonia in the presence of a noble metal catalyst supported by a carrier at 80.degree. to 300.degree. C. under a pressure of 10 to 120 atm, whereby amination, acidification, dehydration and cyclization occur to obtain caprolactam.

Abstract translation: 一种用于制备己内酰胺的简单且单步的方法，其包括使5-甲酰基戊酸或其酯在水和/或醇的溶剂中与氢和氨在80〜300载体负载的贵金属催化剂存在下反应 在10〜120atm的压力下进行胺化，酸化，脱水和环化，得到己内酰胺。

公开(公告)号：US5962680A

公开(公告)日：1999-10-05

申请号：US839576

申请日：1997-04-15

Applicant: Thomas Carl Eisenschmid ,  John Robert Briggs ,  Diane Lee Packett ,  Kurt Damar Olson ,  John Michael Maher

Inventor： Thomas Carl Eisenschmid ,  John Robert Briggs ,  Diane Lee Packett ,  Kurt Damar Olson ,  John Michael Maher

IPC: B01J31/24 ,  C07B61/00 ,  C07D201/02 ,  C07D201/08 ,  C07D223/10 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

CPC classification number: C07D201/02 ,  C07D201/08 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprises: (a) subjecting one or more substituted or unsubstituted alkadienes to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and neutralization with a base to produce one or more substituted or unsubstituted pentenoic acid salts; (b) subjecting said one or more substituted or unsubstituted pentenoic acid salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted formylvaleric acid salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors; and (c) subjecting said one or more substituted or unsubstituted formylvaleric acid salts and/or said one or more substituted or unsubstituted epsilon caprolactam precursors to reductive amination in the presence of a reductive amination catalyst and cyclization optionally in the presence of a cyclization catalyst to produce said one or more substituted or unsubstituted epsilon caprolactams. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as the principal product(s) of reaction.

Abstract translation: 本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：（a）在羟基羰基化催化剂存在下使一种或多种取代或未取代的烷撑二醇进行羟基羰基化， 金属有机磷配体络合物催化剂，并用碱中和以产生一种或多种取代或未取代的戊烯酸盐; （b）使所述一种或多种取代或未取代的戊烯酸盐在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）存在下进行加氢甲酰化，以产生一种或多种取代或未取代的甲酰基戊酸盐和/或一种或多种 更多取代或未取代的ε己内酰胺前体; 和（c）在还原胺化催化剂存在下使所述一种或多种取代或未取代的甲酰基戊酸盐和/或所述一种或多种取代或未取代的己内酰胺前体进行还原胺化，任选地在环化催化剂存在下进行环化， 产生所述一种或多种取代或未取代的ε己内酰胺。 本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为反应主要产物的反应混合物。

公开(公告)号：US5817883A

公开(公告)日：1998-10-06

申请号：US843340

申请日：1997-04-15

Applicant: John Robert Briggs ,  Kurt Damar Olson ,  Erik Bruce Tjaden ,  Anil Sakharam Guram ,  Diane Lee Packett ,  Thomas Carl Eisenschmid ,  Elaine Susan Brigham

Inventor： John Robert Briggs ,  Kurt Damar Olson ,  Erik Bruce Tjaden ,  Anil Sakharam Guram ,  Diane Lee Packett ,  Thomas Carl Eisenschmid ,  Elaine Susan Brigham

IPC: B01J31/24 ,  C07B61/00 ,  C07C29/16 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/08 ,  C07F9/6574 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

CPC classification number: C08G69/36 ,  C07C29/16 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/08 ,  C07F9/65744 ,  C08G69/02 ,  C08G69/14 ,  C07B2200/09 ,  Y02P20/582

Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted hydroxyaldehydes, e.g., 6-hydroxyhexanals, which comprise subjecting one or more substituted or unsubstituted alkadienes, e.g., butadiene, to hydrocarbonylation in the presence of a hydrocarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted hydroxyaldehydes. The substituted and unsubstituted hydroxyaldehydes produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactone. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted hydroxyaldehydes as principal product(s) of reaction.

Abstract translation: 本发明部分涉及用于生产一种或多种取代或未取代的羟基醛（例如6-羟基己醛）的方法，所述方法包括使一种或多种取代或未取代的二烯烃例如丁二烯在烃基催化剂存在下进行烃基化， 金属 - 有机磷配体络合物催化剂，以及在加氢甲酰化催化剂（例如金属 - 有机磷配位体配合物催化剂）存在下加氢甲酰化，以产生一种或多种取代或未取代的羟基醛。 通过本发明的方法制备的取代和未取代的羟基醛可以进一步反应以提供其所需的衍生物，例如ε己内酯。 本发明还部分涉及含有一种或多种取代或未取代的羟基醛作为主要反应产物的反应混合物。

公开(公告)号：US5739324A

公开(公告)日：1998-04-14

申请号：US646279

申请日：1996-05-16

Applicant: Eberhard Fuchs ,  Tom Witzel

Inventor： Eberhard Fuchs ,  Tom Witzel

IPC: C07D223/10 ,  C07D201/08

CPC classification number: C07D201/08

Abstract: A process for preparing cyclic lactams by reacting amino carbonitriles with water in liquid phase in the presence of heterogeneous catalysts based on titanium dioxide, zirconium oxide, cerium oxide and aluminum oxide.

Abstract translation: PCT No.PCT / EP94 / 03781 Sec。 371日期：1996年5月15日 102（e）日期1996年5月16日PCT 1994年11月16日PCT公布。 出版物WO95 / 14664 日期：1995年6月1日在基于二氧化钛，氧化锆，氧化铈和氧化铝的非均相催化剂的存在下，使氨基腈与液相中的水反应制备环状内酰胺的方法。