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公开(公告)号：US20200030384A1
公开(公告)日：2020-01-30
申请号：US16590255
申请日：2019-10-01
IPC分类号： A61K35/51 , C12N5/0789 , A61K35/28 , A61K35/50 , G16B30/00
摘要： The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/progenitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
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公开(公告)号：US20200023005A1
公开(公告)日：2020-01-23
申请号：US16497573
申请日：2018-03-22
IPC分类号： A61K35/14 , A61P17/14 , A61K9/06 , A61K35/50 , A61K9/00 , A61Q17/04 , A61K8/9789 , A61K8/98 , A61K8/60
摘要： The present invention relates to products and methods for treatment of hair loss. Specifically, the present application relates to compositions and methods for prevention and treatment of hair loss, comprising administration of a composition comprising intact mitochondria, ruptured mitochondria and/or mitochondrial constituents.
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公开(公告)号：US10517902B2
公开(公告)日：2019-12-31
申请号：US13826139
申请日：2013-03-14
摘要： The present disclosure generally pertains to methods of treating non-healing wounds. Specifically, the method includes injecting amnion fluid derived cells along the periphery of the wound. The wound is then treated with a placental membrane material including a plurality of slits for increasing the membranes capacity to expand. The slits produce a mesh-like pattern in the membrane material. The amniotic derived cells deliver to the wound electrolytes, growth factors, carbohydrates, lipids, proteins, amino acids, lactate, pyruvate, enzymes, hormones and other factors useful in wound repair. The membrane material provides a scaffolding structure supporting cell growth, prevents microbial infection and decreases the rate of passive evaporative water and heat loss. The combination of the amniotic derived cells and the membrane material protects the wound and promotes cell regeneration.
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公开(公告)号：US20190328795A1
公开(公告)日：2019-10-31
申请号：US16505133
申请日：2019-07-08
申请人： Gary M. Petrucci
发明人： Gary M. Petrucci
摘要： This document provides methods and materials for treating lung conditions induced by inhalable insulin therapy. For example, compositions including a dried amnion tissue preparation and/or a dried stem cell preparation as well as methods for using such compositions to treat inhalable insulin induced lung conditions are provided.
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公开(公告)号：US20190314422A1
公开(公告)日：2019-10-17
申请号：US16385226
申请日：2019-04-16
申请人： Brahm Holdings, LLC
发明人： Timothy R. BRAHM
摘要： The present disclosure generally relates to constructs, formulations and methods for the treatment of various types of cancer. The constructs, formulations and methods as provided herein are particularly useful for the treatment of various tumorigenic cancers.
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公开(公告)号：US10441490B2
公开(公告)日：2019-10-15
申请号：US16242732
申请日：2019-01-08
申请人： Amnion Life, LLC
IPC分类号： A61G11/00 , A61K35/50 , A61M1/02 , A61K35/51 , A61M1/16 , A61M1/36 , A01N1/02 , A61M5/44 , A61K35/12
摘要： Described herein are systems, devices, and methods for an extracorporeal, artificial, placenta. In some embodiments, an artificial placenta and amniotic bed system may comprise a control unit, a gas delivery unit, a gas exchange unit or membrane oxygenator, a fluids delivery unit, an amniotic fluid bed, and a human machine interface. In some embodiments, the artificial placenta and amniotic bed systems, devices, and methods described herein may improve survival rates and minimize long-term disabilities in preterm, gestational-age, newborns. In some embodiments, the extracorporeal systems, devices, and methods comprise an artificial network through which oxygen and nutrient-rich blood may flow into a fetus (residing in an amniotic fluid bed), while carbon dioxide and wastes may be removed, thus re-establishing a form of intrauterine placental circulation.
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公开(公告)号：US20190307686A1
公开(公告)日：2019-10-10
申请号：US16194278
申请日：2018-11-16
申请人： Celularity, Inc.
发明人： Qian Ye
IPC分类号： A61K9/127 , C12N5/0783 , C12N5/073 , C12N5/0781 , C12N5/0789 , A61K35/17 , A61P35/00 , A61K35/50 , A61K35/22 , A61K31/7105 , A61K38/17 , A61K9/00
摘要： Several approaches to produce, isolate, and characterize exosomes recovered from a cultivated placenta or a portion thereof are provided. The alternatives described herein facilitate the production, isolation, and characterization of exosomes, which can be used as biotechnological tools and therapeutics. Also provided herein are populations of exosomes derived from placenta organ culture or culture of portions of the placenta. Also provided are compositions comprising the populations of exosomes and methods of their use for the treatment of subjects.
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78.发明申请公开(公告)号：US20190300848A1
公开(公告)日：2019-10-03
申请号：US16288809
申请日：2019-02-28
IPC分类号： C12N5/073 , A01N1/02 , A61K9/00 , A61K35/50 , A61K35/51 , A61K8/98 , A61K8/67 , A61K31/455 , A61K31/355 , A61Q19/08 , A61Q19/00 , C12N5/0775 , A61L27/54 , A61L27/36 , A61P17/02
摘要： Compositions are provided that contain biologically active components of amniotic fluid including growth factors and other proteins, carbohydrates, lipids, and metabolites. The compositions containing biologically active components of amniotic fluid can be useful for a range of therapeutic treatments including joint and soft tissue repair, regulation of skin condition, and for use in organ preservation, such as for use in organ transplant procedures. Advantages of the compositions include that they can be reproducibly produced, without the inherent variability of amniotic fluid from individual donors, and that they are free of fetal waste.
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公开(公告)号：US20190298777A1
公开(公告)日：2019-10-03
申请号：US16378206
申请日：2019-04-08
IPC分类号： A61K35/51 , C12N5/0789 , A61K35/50
摘要： The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
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公开(公告)号：US10406259B2
公开(公告)日：2019-09-10
申请号：US15655020
申请日：2017-07-20
申请人： MiMedx Group, Inc.
发明人： John Daniel
摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
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