公开(公告)号：US11001641B2

公开(公告)日：2021-05-11

申请号：US16162731

申请日：2018-10-17

申请人： PRECISION BIOLOGICS, INC.

发明人： Myron Arlen ,  Kwong Tsang

IPC分类号： A61K39/00 ,  C07K16/30 ,  A61K47/68 ,  A61K39/395 ,  G01N33/574 ,  A61K49/04 ,  A61K49/16 ,  A61K49/22

摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.

公开(公告)号：US20210128454A1

公开(公告)日：2021-05-06

申请号：US17142559

申请日：2021-01-06

申请人： Persica Pharmaceuticals Ltd.

发明人： Lloyd Czaplewski ,  Sarah Guest

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K31/5377 ,  A61K38/14 ,  A61K47/10 ,  A61K49/04 ,  A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

摘要： The present invention relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogel formulations comprising at least one antibiotic for relieving and/or treating low back pain.

公开(公告)号：US10980902B2

公开(公告)日：2021-04-20

申请号：US16317757

申请日：2017-07-14

申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

发明人： Jesus Manuel Perez ,  Santimukul Santra

IPC分类号： A61K51/06 ,  A61P35/00 ,  A61K31/519 ,  A61K49/04 ,  C08G63/688 ,  C08G83/00

摘要： Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.

公开(公告)号：US10973770B2

公开(公告)日：2021-04-13

申请号：US14720428

申请日：2015-05-22

申请人： Varian Medical Systems, Inc. ,  Gretchen B. Wojcik

发明人： Ulf Fritz ,  Olaf Fritz ,  Thomas A. Gordy ,  Ronald Wojcik ,  Jacques Blummel ,  Alexander Kuller

IPC分类号： A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/00

摘要： Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.

公开(公告)号：US10953097B2

公开(公告)日：2021-03-23

申请号：US15341924

申请日：2016-11-02

申请人： NANOFIBER SOLUTIONS, LLC

发明人： Jed Johnson ,  Devan Ohst ,  Jason Chakroff

IPC分类号： A61K9/70 ,  A61K47/34 ,  A61L27/54 ,  A61L27/58 ,  A61L27/18 ,  A61L27/50 ,  A61K49/04 ,  D01D5/00 ,  A61K49/00 ,  D01F1/09 ,  D01F1/10

摘要： A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.

公开(公告)号：US10945965B2

公开(公告)日：2021-03-16

申请号：US14364859

申请日：2012-12-17

申请人： NANOBIOTIX

发明人： Agnes Pottier ,  Laurent Levy ,  Marie-Edith Meyre

IPC分类号： A61K33/24 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  A61K51/12 ,  A61N5/10 ,  A61K9/51 ,  A61K9/00

摘要： The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with a hafnium oxide material or embedded therein. When compared to existing products, these nanoparticles offer a remarkable benefit over risk ratio. Specifically, these nanoparticles potentiate the efficiency of known metallic nanoparticles. Indeed, they retain the metal's intrinsic properties and are now in addition safely usable in a mammal, in particular in a human being. The invention also relates to methods for producing said nanoparticles, to compositions containing same, and to uses thereof.

公开(公告)号：US10940329B2

公开(公告)日：2021-03-09

申请号：US15819130

申请日：2017-11-21

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Mark Oldham ,  Justus Adamson ,  Paul Yoon ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Wayne F. Beyer

IPC分类号： A61K49/00 ,  A61N5/10 ,  C09K11/59 ,  C09K11/73 ,  C09K11/02 ,  A61K31/37 ,  A61P35/00 ,  A61K41/00 ,  A61K49/04

摘要： A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.

公开(公告)号：US10925979B2

公开(公告)日：2021-02-23

申请号：US16733405

申请日：2020-01-03

申请人： BIOCOMPATIBLES UK LTD.

发明人： Stephane Hohn ,  Andrew Lennard Lewis ,  Sean Leo Willis ,  Matthew R. Dreher ,  Koorosh Ashrafi ,  Yiqing Tang

IPC分类号： A61K9/00 ,  A61K49/04 ,  A61L24/00 ,  A61L24/06 ,  C08F116/06

摘要： This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.

公开(公告)号：US10898593B2

公开(公告)日：2021-01-26

申请号：US15310395

申请日：2015-05-13

申请人： Yale University

发明人： Tarek Fahmy ,  Albert Sinusas ,  Dongin Kim

IPC分类号： A61K49/04 ,  C08K9/10 ,  C08J3/12 ,  A61K49/18 ,  C08K3/16

摘要： Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR contrast agents. Examples include, but are not limited to, multivalent linear polymers, branched polymers, or hyperbranched polymers, such as dendrimers, and combinations thereof. The dendrimer is functionalized with one or more high Z-elements, such as iodine. The high Z-elements can be covalently or non-covalently bound to the dendrimer. The dendrimers are confined in order to enhance CT contrast. In some embodiments, the moiety is confined by encapsulating the dendrimers in a material to form particles, such as nanoparticles. In other embodiments, the dendrimer is confined by conjugating the moiety to a material, such as a polymer, which forms a gel upon contact with bodily fluids.

公开(公告)号：US10857237B2

公开(公告)日：2020-12-08

申请号：US15571763

申请日：2016-05-05

申请人： University of Louisville Research Foundation, Inc.

发明人： Mohammad Tariq Malik ,  Martin G. O'Toole ,  Paula J. Bates

IPC分类号： A61K49/00 ,  A61K47/69 ,  A61K41/00 ,  A61K49/04 ,  A61K31/28 ,  A61K45/06 ,  A61K31/7105 ,  A61K49/18 ,  A61K9/00 ,  A61K47/54 ,  A61P35/00 ,  C07K16/18 ,  C07K16/30 ,  C12N15/115

摘要： A composition comprises an anti-nucleolin agent conjugated to nanoparticles, and optionally containing gadolinium. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier. The composition enhances the effectiveness of radiation therapy, enhancing contrast in X-ray imaging techniques, and when gadolinium is present, provide cancer selective MRI contrast agents.