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    Compositions for nanoconfinement induced contrast enhancement and methods of making and using thereof
    1.
    发明授权
    Compositions for nanoconfinement induced contrast enhancement and methods of making and using thereof 有权

    公开(公告)号：US10898593B2

    公开(公告)日：2021-01-26

    申请号：US15310395

    申请日：2015-05-13

    申请人： Yale University

    发明人： Tarek Fahmy ,  Albert Sinusas ,  Dongin Kim

    IPC分类号： A61K49/04 ,  C08K9/10 ,  C08J3/12 ,  A61K49/18 ,  C08K3/16

    摘要： Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR contrast agents. Examples include, but are not limited to, multivalent linear polymers, branched polymers, or hyperbranched polymers, such as dendrimers, and combinations thereof. The dendrimer is functionalized with one or more high Z-elements, such as iodine. The high Z-elements can be covalently or non-covalently bound to the dendrimer. The dendrimers are confined in order to enhance CT contrast. In some embodiments, the moiety is confined by encapsulating the dendrimers in a material to form particles, such as nanoparticles. In other embodiments, the dendrimer is confined by conjugating the moiety to a material, such as a polymer, which forms a gel upon contact with bodily fluids.

    POLYMERIC BILE ACID NANOPARTICLES AS ANTI-INFLAMMATORY AGENTS
    2.
    发明申请
    POLYMERIC BILE ACID NANOPARTICLES AS ANTI-INFLAMMATORY AGENTS 审中-公开

    公开(公告)号：US20200316207A1

    公开(公告)日：2020-10-08

    申请号：US16906695

    申请日：2020-06-19

    申请人： Yale University

    发明人： Jung Seok Lee ,  Tarek M. Fahmy ,  Dongin Kim

    IPC分类号： A61K47/28 ,  A61K9/51 ,  A61K35/413 ,  A61P29/00

    摘要： Polymeric poly(bile acid) (pBA) nanoparticles have enhanced avidity and affinity to bile acid receptors and are effective anti-inflammatory agents. Oral delivery results in local accumulation and retention in the pancreas, liver, and colon as well as in systemic delivery of the nanoparticles. The nanoparticles are effective in alleviating inflammation and are useful as anti-inflammatory agents to treat inflammatory diseases of the organs. The nanoparticles provide a therapeutic and prophylactic benefit via the TGR5 pathway when used alone, or a more than additive benefit when used in combination with immunosuppressant(s). The nanoparticles induce immune tolerance in autoimmune diseases and are useful therapeutics for treating inflammatory and autoimmune diseases.

    POLYMERIC BILE ACID ESTER NANOPARTICLES TO INDUCE TOLERANCE
    5.
    发明申请
    POLYMERIC BILE ACID ESTER NANOPARTICLES TO INDUCE TOLERANCE 审中-公开

    公开(公告)号：US20200315982A1

    公开(公告)日：2020-10-08

    申请号：US16907055

    申请日：2020-06-19

    申请人： Yale University

    发明人： Jung Seok Lee ,  Tarek M. Fahmy ,  Dongin Kim

    IPC分类号： A61K9/51 ,  A61K35/413 ,  A61K47/28 ,  A61K31/436 ,  A61K38/28 ,  A61P3/10

    摘要： Polymeric bile acid (pBA) nanoparticles and tolerogenic formulation containing polymeric bile acid nanoparticles for oral delivery and induction of antigen-specific tolerance in a subject may include immunosuppressants and/or disease-specific antigen. Oral delivery results in local organ accumulation as well as systemic delivery of the nanoparticles. Early intervention with the nanoparticles induces antigen-specific tolerance and prevents development of autoimmune disorders. Treatment with the nanoparticles results in long-term antigen-specific immune tolerance, even after cessation of treatment, in autoimmune diseases.