公开(公告)号：US20220064644A1

公开(公告)日：2022-03-03

申请号：US17461876

申请日：2021-08-30

Applicant: TAIPEI MEDICAL UNIVERSITY ,  NATIONAL YANG MING CHIAO TUNG UNIVERSITY ,  ACADEMIA SINICA ,  NATIONAL TAIWAN NORMAL UNIVERSITY

Inventor： Bing-Wen SOONG ,  Ueng-Cheng YANG ,  Yu-Shuen TSAI ,  Tzu-Hao CHENG ,  Yi-Juang CHERN ,  Ming-Tsan SU ,  Yi-Ching CHANG ,  Yan Hua LEE

IPC: C12N15/113 ,  A61K31/7115

Abstract: The present disclosure relates to a method of identifying a genetic modifier of a nucleotide repeat disorder, comprising selecting from the subjects the late-onset subjects with higher nucleotide repeat load or the early-onset subjects with lower nucleotide repeat load and identifying one or more genetic modifiers delaying or promoting onset of a nucleotide repeat disorder. The present disclosure also relates to a method for treating or preventing a polyglutamine (polyQ) expansion disease in a subject in need of such treatment or prevention, comprising administering an effective amount of a PIAS1 variant or a recombinant nucleic acid molecule encoding the PIAS1 variant to the subject. The present disclosure also relates to a method for treating or preventing early symptoms onset of the polyglutamine expansion disease, a PIAS1 variant, comprising one or more sequence changes located in the C-terminal region of PIAS1 and a recombinant nucleic acid molecule encoding the PIAS1 variant as disclosed herein.

公开(公告)号：US11246883B2

公开(公告)日：2022-02-15

申请号：US16337583

申请日：2017-09-29

Applicant: Academia Sinica

Inventor： Patrick C. H. Hsieh ,  Chen-Yun Chen ,  Yu-Che Cheng

IPC: A61K31/7105 ,  A61K9/00 ,  C07K16/28 ,  C12N15/113 ,  A61K48/00 ,  A61K39/00

Abstract: Methods for ameliorating cardiac is juries such as myocardial infarction by either enhancing the activity of a let-7 microRNA or inhibiting the activity of transformation growth factor beta receptor III (T GFBR3). Also provided herein are assay methods for detecting the level of TGFBR3, the level of a let-7 microRNA, or both in a biological sample.

公开(公告)号：US20220000817A1

公开(公告)日：2022-01-06

申请号：US17289736

申请日：2019-11-01

Applicant: Academia Sinica

Inventor： Wei-Chao CHANG ,  Chung-Hsuan CHEN

IPC: A61K31/192 ,  C12N15/113 ,  A61K31/7105 ,  C12N15/115 ,  C07K16/18 ,  A61P35/04

Abstract: Provided herein is a method for treating a subject afflicted with a metastatic cancer. The method includes, administering to the subject an effective amount of an agent capable of suppressing the expression of a nucleic of EF-hand domain-containing protein D2 (EFHD2) or a polypeptide encoded by the nucleic acid in the metastatic cancer of the subject. The agent may be a 2-aryl propionic acid (2-APA) compound, or a short hairpin ribonucleic acid (shRNA) that directs cleavage of EFHD2 gene RNA via RNA interference. Also provided herein is a method for detecting and/or diagnosing whether a subject having a metastatic cancer via a biological sample of the subject. The method includes steps of, measuring the level of EFHD2 nucleic acid or polypeptide in the biological sample; and comparing the amount of the EFHD2 nucleic acid or polypeptide present in the biological sample with that of a healthy subject; in which an elevated amount of EFHD2 nucleic acid or polypeptide in the biological sample relative to that of a healthy subject indicates that the cancer of the subject is likely to metastasize.

公开(公告)号：US11214774B2

公开(公告)日：2022-01-04

申请号：US15571249

申请日：2016-05-02

Applicant: Andrew Man Chung Wo ,  National Taiwan University ,  Academia Sinica

Inventor： Pan-Chyr Yang ,  Pei-Ying Lin ,  Bo-Tsang Huang

IPC: C07K5/00 ,  C12N9/12 ,  A61K45/06 ,  C07K14/00 ,  A61K39/395 ,  C07K14/71 ,  A61K31/517 ,  A61K38/17 ,  A61K31/5377 ,  A61P35/00 ,  A61K38/45

Abstract: The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.

公开(公告)号：US11207289B2

公开(公告)日：2021-12-28

申请号：US16087093

申请日：2017-03-17

Applicant: ACADEMIA SINICA

Inventor： Ning-Sun Yang ,  Yueh-Hsiung Kuo ,  Shu-Yi Yin ,  Yung-Hsiang Chen

IPC: A61K31/343 ,  A61P35/04 ,  A61K31/337

Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).

公开(公告)号：US20210386820A1

公开(公告)日：2021-12-16

申请号：US17274122

申请日：2019-09-06

Applicant: ACADEMIA SINICA

Inventor： Che MA ,  Yu-Min LIU ,  Jia-Tsrong JAN

IPC: A61K38/17 ,  A61P31/16

Abstract: The present invention relates to antiviral lectin and uses thereof. Particularly, the present invention relates to a complex-type (CX-type) and/or hybrid-type (HY-type) glycan binding lectin for use in treating or preventing influenza virus infection. The present invention also provides a method for treating or preventing influenza virus infection by administrating to a subject in need said lectin or a composition comprising the same.

公开(公告)号：US20210371899A1

公开(公告)日：2021-12-02

申请号：US17285945

申请日：2019-10-17

Applicant: ACADEMIA SINICA

Inventor： Yu-Chan CHAO ,  Lin-Li LIAO ,  Chuan-yu LIAO ,  Chih-Hsuan TSAI ,  Paul Wei-che HSU

IPC: C12Q1/46 ,  C12N9/18 ,  G06N20/10 ,  G01N21/78

Abstract: This disclosure provides a method and a kit for pesticide detection. By expressing acetylcholinesterases on cell surface, rapid pesticide screening, identification and quantification of pesticides or insecticides may be achieved.

公开(公告)号：US20210324335A1

公开(公告)日：2021-10-21

申请号：US17273256

申请日：2019-09-03

Applicant: ACADEMIA SINICA

Inventor： Han-Chung WU ,  I-I KUAN ,  Chien-Hsu CHEN

IPC: C12N5/0775

Abstract: The present invention generally relates to a medium composition and method for culturing mesenchymal stem cells (MSCs), in which the medium comprises an epithelial cell adhesion molecule (EpCAM) peptide, particularly a truncated EpCAM polypeptide containing the extracellular domain (EpEX). It significantly enhances cell proliferation and multipotency of the MSCs.

公开(公告)号：US11141428B2

公开(公告)日：2021-10-12

申请号：US16771643

申请日：2018-12-12

Applicant: Academia Sinica

Inventor： Shang-Cheng Hung ,  Kenji Kadomatsu ,  Kazuma Sakamoto ,  Yen-Chun Ko ,  Cheng-Fang Tsai ,  Chiao-Yuan Fan

IPC: A61K31/737 ,  A61P25/00 ,  C08B37/00

Abstract: Disclosed herein is a sulfated octasacchande of formula (I), a pharmaceutically acceptable salt, solvate or ester thereof: wherein R1 is —NHAc or —NHSO3H; and R2 and R3 are independently H, or —SO3H. Also encompasses herein is a method of treating neuron injury and/or diseases associated with a disrupted autophagy flux. The method includes administering an effective amount of the sulfated octasaccharide of formula (I) to a subject in need of such treatment.

公开(公告)号：US20210292413A1

公开(公告)日：2021-09-23

申请号：US17266092

申请日：2018-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang HSIEH ,  Tsung-Yu TSAI ,  An-Suei YANG ,  Chung-Ming YU ,  Cheng-Yuan PENG

IPC: C07K16/28 ,  A61P31/20

Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.