公开(公告)号：US20220079975A1

公开(公告)日：2022-03-17

申请号：US17017937

申请日：2020-09-11

Applicant: HI-Q MARINE BIOTECH INTERNATIONAL LTD. ,  TAIPEI MEDICAL UNIVERSITY ,  Taipei Municipal Wanfang Hospital (Managed by Taipei Medical University)

Inventor： Ming-Shun WU

IPC: A61K31/737 ,  A61K31/336 ,  A61K9/00 ,  A61P1/16

Abstract: The present invention relates to a method for mitigation of non-alcoholic fatty liver disease, the method comprising administering an effective amount of a composition comprising small-molecule fucoidan and fucoxanthin to a subject in need thereof, and achieves the efficacy by means of improving the controlled attenuation parameter and blood biochemical parameters such as alanine aminotransferase (ALT), glucose ante cibum (AC) and glycated hemoglobin (HbA1c).

公开(公告)号：US20240398823A1

公开(公告)日：2024-12-05

申请号：US18689198

申请日：2022-09-06

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： Kuo-Hsiang CHUANG ,  Jing-Ping LIOU ,  Yun YEN

IPC: A61K31/5377 ,  A61K31/166 ,  A61K31/445 ,  A61K31/495 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07C233/81 ,  C07D211/26 ,  C07D241/04 ,  C07D295/13 ,  C07D317/46

Abstract: The present invention provides a dual inhibitor that inhibits histone deacetylase 6 (HDAC6) and heat shock protein 90 (HSP90) for amelioration and/or treatment of tumors through removal of immune suppression from tumor microenvironments or stimulation of an immune system against tumors. Pharmaceutical compositions comprising the dual inhibitor and uses thereof are also provided.

公开(公告)号：US12159402B2

公开(公告)日：2024-12-03

申请号：US17662659

申请日：2022-05-10

Applicant: Taipei Medical University (TMU) ,  TAIPEI VETERANS GENERAL HOSPITAL

Inventor： Syu-Jyun Peng ,  Chien-Chen Chou ,  Yen-Cheng Shih ,  Hsu-Huai Chiu

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/1455 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70

Abstract: The present disclosure provides an operating method of a brain imaging neurological abnormality prediction system, which includes steps as follows. The T1-weighted image and the diffusion-weighted image of the patient are acquired; the image process is performed on the T1-weighted image and the diffusion-weighted image to obtain a smoothed brain standard space infarction image; the smoothed brain standard space infarction image is multiplied by and a weighted image for a post-processing to obtain a post-weight image; the post-weight image is inputted to the deep learning cross validation classification model of transfer learning to predict whether the neurological abnormality occurs within a predetermined period after the patient's brain disease.

公开(公告)号：US12133739B2

公开(公告)日：2024-11-05

申请号：US18539555

申请日：2023-12-14

Applicant: AcroViz USA Inc. ,  Taipei Medical University

Inventor： Wen-Yih Tseng ,  Yung-Chin Hsu ,  Lung Chan ,  Chien-Tai Hong ,  Yueh-Hsun Lu ,  Jia-Hung Chen ,  Li-Kai Huang

IPC: A61B5/00 ,  A61B5/055 ,  G06T7/00

Abstract: A method of predicting a brain atrophy condition for an individual using the individual's predicted age difference (PAD). The method comprises acquiring at least one brain image of the individual; processing the brain image to obtain at least one feature of the brain image; generating a PAD value of the individual based on the at least one feature of the image; and determining a brain atrophy condition of the individual based on the PAD value.

公开(公告)号：US20240215875A1

公开(公告)日：2024-07-04

申请号：US18400268

申请日：2023-12-29

Applicant: NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY ,  TAIPEI MEDICAL UNIVERSITY

Inventor： CHENG-CHUN CHANG ,  PO-WEN LU

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/7267 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/0242

Abstract: A wearable device and a method for selecting and interpreting light intensity data values applicable thereto. The wearable device includes a light emitting unit and a spectrum sensing unit. The method includes steps of: controlling the light-emitting unit to simultaneously emit a mixed light including multiple spectrum frequency bands to enter inside skin of the user; controlling the spectrum sensing unit to sense the intensity of an outgoing light from inside skin of the user at a series of sampling time to generate a spectrum data set including a plurality of groups of frequency band-light intensity data values; and selecting at least one of a first group of frequency band-light intensity data values satisfying a signal quality index in the spectrum data set to perform a data interpretation at a first judgment time point.

公开(公告)号：US20240144471A1

公开(公告)日：2024-05-02

申请号：US17978226

申请日：2022-11-01

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： Cheng-Yu CHEN ,  David Carroll CHEN

IPC: G06T7/00 ,  A61B6/00 ,  G06T7/12 ,  G06T7/40 ,  G06T7/60 ,  G06T7/70 ,  G16H30/20 ,  G16H50/20

CPC classification number: G06T7/0012 ,  A61B6/503 ,  A61B6/504 ,  G06T7/12 ,  G06T7/40 ,  G06T7/60 ,  G06T7/70 ,  G16H30/20 ,  G16H50/20 ,  A61B6/032 ,  G06T2207/10081 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30064 ,  G06T2207/30101

Abstract: Disclosed are methods and devices of processing a low-dose computed tomography (CT) image. The present disclosure provides a method of processing a low-dose CT image. The method comprises: receiving a first chest image; receiving a first chest image; detecting at least one lung nodule in the first chest image; determining at least one lung nodule region of the first chest image based on the at least one lung nodule; and classifying the at least one lung nodule region based on a first set of radiomics features of the at least one lung nodule region of the first chest image to obtain a nodule score of the at least one lung nodule in the lung nodule region. The first chest image generated by a low-dose CT method.

公开(公告)号：US20240122856A1

公开(公告)日：2024-04-18

申请号：US18397342

申请日：2023-12-27

Applicant: Taipei Medical University ,  Panion & BF Biotech Inc.

Inventor： Ming-Thau SHEU ,  Yu-Ying HSU ,  Yu-De SU ,  Yu-Hsuan LIU ,  Pu-Sheng WEI

IPC: A61K9/16 ,  A61K9/10 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38

CPC classification number: A61K9/1682 ,  A61K9/10 ,  A61K9/1647 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38

Abstract: A method of preparing polylactic acid (PLA) microsphere and polylactic-co-glycolic acid (PLGA) microsphere is provided, including the following steps. A first solution is provided, including polylactic acid or polylactic-co-glycolic acid and an organic solvent. A second solution is provided, including polyvinyl alcohol, sodium carboxymethyl cellulose and an aqueous solution. The first solution is added to the second solution and, at the same time, the second solution is agitated until polylactic acid is solidified to form a plurality of polylactic acid microspheres, or until polylactic-co-glycolic acid is solidified to form a plurality of polylactic-co-glycolic acid microspheres. The polylactic acid microspheres or polylactic-co-glycolic acid microspheres are collected. The polylactic acid microsphere and the polylactic-co-glycolic acid microsphere are respectively the accumulation of the polylactic acid and polylactic-co-glycolic acid, having a smooth surface and a mean number particle size distribution (MN) from 10 μm to 80 μm.

公开(公告)号：US20240122669A1

公开(公告)日：2024-04-18

申请号：US18153313

申请日：2023-01-11

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： Chih-Wei PENG ,  Chun-Wei WU ,  Chun-Ying CAI ,  Yen CHENG

IPC: A61B90/14 ,  A61D1/00

CPC classification number: A61B90/14 ,  A61D1/00

Abstract: An ear canal clamp for small animals includes a base and a clamping mechanism. The clamping mechanism includes two clamping arms movably mounted on the base, a biasing member mounted on the base and constrained between the clamping arms, and two ear canal positioning members mounted respectively to the clamping arms and facing each other. The clamping arms are configured to move toward each other and compress the biasing member to increase the distance between the ear canal positioning members. A biasing force generated by the biasing member when compressed is used to push the clamping arms to move oppositely with respect to each other.

公开(公告)号：US20240096476A1

公开(公告)日：2024-03-21

申请号：US18467722

申请日：2023-09-14

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： CHAO-WEI CHEN

IPC: G16H20/70 ,  G06T7/00

CPC classification number: G16H20/70 ,  G06T7/0012 ,  G06T2207/10088 ,  G06T2207/20081

Abstract: The present application provides a method for providing cognitive training by using a computing device. The method includes prompting a first target object for recognizing by a user; receiving a feedback response from the user by the computing device; determining a correctness of the feedback response by comparing the feedback response with a stored answer by the computing device; and adjusting a level or a type of a second target object based on a guideline associated with the correctness of the feedback response. The second target object is provided for recognizing by the user after the first target object is provided. In addition, the present application also provides a computing device for providing cognitive training and a non-transitory computer-readable recording medium capable of providing cognitive training.

公开(公告)号：US20240023878A1

公开(公告)日：2024-01-25

申请号：US18225312

申请日：2023-07-24

Applicant: AcroViz USA Inc. ,  Taipei Medical University

Inventor： Wen-Yih Tseng ,  Yung-Chin Hsu ,  Lung Chan ,  Chien-Tai Hong ,  Yueh-Hsun Lu ,  Jia-Hung Chen ,  Li-Kai Huang

IPC: A61B5/00 ,  G06T7/00 ,  A61B5/055

CPC classification number: A61B5/4088 ,  A61B5/7275 ,  G06T2207/10092 ,  A61B5/055 ,  G06T2207/30016 ,  G06T7/0012

Abstract: A method of predicting therapeutic effects of a treatment for cognitive impairment for an individual using the individual's predicted age difference (PAD), the method comprising scanning the individual's brain with a scanning device so as to acquire at least one medical brain image at the beginning of the treatment; processing the medical brain image to obtain at least one feature of the image; generating a PAD value of the individual based on the at least one feature of the image; comparing the PAD value with a reference value; and predicting the therapeutic effects of the treatment for cognitive impairment using the comparison result of the PAD value and the reference value.