公开(公告)号：US06821485B2

公开(公告)日：2004-11-23

申请号：US10071846

申请日：2002-02-08

Applicant: David J. Beebe ,  Jeffrey S. Moore ,  Bin Zhao

Inventor： David J. Beebe ,  Jeffrey S. Moore ,  Bin Zhao

IPC: B01L302

CPC classification number: B82Y30/00 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/089 ,  B01L2400/0672 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A flow of liquids is carried out on a microscale utilizing surface effects to guide the liquid on flow paths to maintain laminar flow. No sidewall confining structure is required, minimizing resistance to flow and allowing laminar flow to be maintained at high flow rates. The guiding structure has flow guiding stripes formed on one or both of facing base and cover surfaces which are wettable by a selected liquid to direct the liquid from a source location to a destination location. The regions adjacent to the guiding stripes on the base and cover surfaces are non-wettable. The smooth interface between the gas and liquid along the flowing stream allows gas-liquid reactions to take place as a function of diffusion across the interface without mixing of the gas and liquid. Liquid-liquid flows may also be guided with such structures.

Abstract translation: 使用表面效应在微尺度上进行液体流动以将液体引导到流动路径上以保持层流。 不需要侧壁约束结构，使流动阻力最小化，并允许层流维持在高流速。 引导结构具有形成在一个或两个相对的基底和盖表面上的流动引导条纹，其可被选定的液体润湿以将液体从源位置引导到目的地位置。 在基部和盖表面上与引导条相邻的区域是不可润湿的。 沿着流动流动的气体和液体之间的平滑界面允许气 - 液反应作为扩散跨越界面而发生，而不会混合气体和液体。 液 - 液流也可以用这种结构引导。

公开(公告)号：US06523559B2

公开(公告)日：2003-02-25

申请号：US09917523

申请日：2001-07-27

Applicant: David J. Beebe ,  Jeffrey S. Moore ,  Robin Liu ,  David T. Eddington

Inventor： David J. Beebe ,  Jeffrey S. Moore ,  Robin Liu ,  David T. Eddington

IPC: G05D1103

CPC classification number: G05D11/08 ,  G05D21/00 ,  Y10T137/0329 ,  Y10T137/2509

Abstract: In accordance with the present invention, a microfluidic device and method of using the same is provided for self-regulating the flow of fluid therethrough. The microfluidic device includes a body defining first and second flow channels. The first flow channel has an input for receiving the fluid and an output. The second flow channel has an input for receiving a compensating fluid to modify the value of the property of the fluid and an output communicating with the first flow channel. A polymeric material is disposed in the first flow channel downstream of the output of the second flow channel. The polymeric material has a volume responsive to the value of the property of the fluid. A valve is disposed in the second flow channel and is movable in response to the volume of the material. The valve is movable between the first open position allowing the compensating fluid to flow past the valve into the first flow channel and a second closed position limiting the flow of compensating fluid therepast.

Abstract translation: 根据本发明，提供了一种微流体装置及其使用方法，用于自我调节流体的流动。 微流体装置包括限定第一和第二流动通道的主体。 第一流道具有用于接收流体和输出的输入。 第二流动通道具有用于接收补偿流体以修改流体性质的值的输入和与第一流动通道连通的输出。 聚合材料设置在第二流动通道的第二流动通道的输出的下游。 聚合物材料具有响应于流体性质的值的体积。 阀设置在第二流动通道中并且可以响应于材料的体积而移动。 所述阀可在所述第一打开位置和所述第一关闭位置之间移动，所述第一打开位置允许所述补偿流体流过所述阀进入所述第一流动通道，以及限制所述补偿流体的流动的第二关闭