公开(公告)号：US20110180005A1

公开(公告)日：2011-07-28

申请号：US12972784

申请日：2010-12-20

Applicant: Stephen Aisthorpe ,  David Kay

Inventor： Stephen Aisthorpe ,  David Kay

IPC: A01K5/01

CPC classification number: A01K5/01 ,  A01K5/0107

Abstract: A housing for animal feedstuff including a base, a roof extending over the base, uprights spaced apart from one another and extending between the base and the roof, and a container locatable between the uprights for containing feedstuff. Livestock, such as cattle, access feedstuff within the container by way of spaces between the uprights. In an embodiment, the uprights are telescopic and the roof can be pivoted between raised and lowered positions relative to the uprights.

Abstract translation: 一种用于动物饲料的壳体，包括基部，在基部上延伸的屋顶，彼此间隔开并在基部和屋顶之间延伸的立柱以及位于用于容纳饲料的立柱之间的容器。 牲畜，如牛，通过立柱之间的空间进入容器内的饲料。 在一个实施例中，立柱是可伸缩的，并且屋顶可以相对于立柱在升高和降低的位置之间枢转。

公开(公告)号：US20100190765A1

公开(公告)日：2010-07-29

申请号：US12569237

申请日：2009-09-29

Applicant: David Kay ,  Ronald Knegtel ,  Jean-Damien Charrier ,  Heather Twin

Inventor： David Kay ,  Ronald Knegtel ,  Jean-Damien Charrier ,  Heather Twin

IPC: A61K31/551

CPC classification number: C07D487/04 ,  A61K31/551 ,  A61K45/06 ,  C07D487/14

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US20090062292A1

公开(公告)日：2009-03-05

申请号：US11786578

申请日：2007-04-12

Applicant: Jean-Damien Charrier ,  David Kay ,  Ronald Knegtel

Inventor： Jean-Damien Charrier ,  David Kay ,  Ronald Knegtel

IPC: A61K31/519 ,  C07D487/14

CPC classification number: C07D487/14

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US20080167289A1

公开(公告)日：2008-07-10

申请号：US11706070

申请日：2007-02-13

Applicant: David Kay ,  Ronald Knegtel ,  Jean-Damien Charrier ,  Heather Twin

Inventor： David Kay ,  Ronald Knegtel ,  Jean-Damien Charrier ,  Heather Twin

IPC: A61K31/397 ,  C07D243/10 ,  C12N9/99 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/551

CPC classification number: C07D487/04 ,  A61K31/551 ,  A61K45/06 ,  C07D487/14

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US20070190634A1

公开(公告)日：2007-08-16

申请号：US11786150

申请日：2007-04-11

Applicant: David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

Inventor： David Bebbington ,  Hayley Binch ,  Jean-Damien Charrier ,  Simon Everitt ,  Julian Golec ,  David Kay ,  Ronald Knegtel ,  Andrew Miller ,  Francoise Pierard

IPC: C02F3/34

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：US20060270660A1

公开(公告)日：2006-11-30

申请号：US11500981

申请日：2006-08-09

Applicant: Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

Inventor： Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

IPC: A61K31/551 ,  A61K31/5377 ,  A61K31/513 ,  C07D403/14 ,  C07D413/14

CPC classification number: C07D403/14 ,  C07D239/34 ,  C07D401/14 ,  C07D403/12 ,  C07D453/02

Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.

Abstract translation: 本发明提供了制备三取代和四取代嘧啶的简便方法。 该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。 这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。

公开(公告)号：US20060173462A1

公开(公告)日：2006-08-03

申请号：US11340365

申请日：2006-01-26

Applicant: David Kay ,  Lee Strnad ,  Dustin Ducharme

Inventor： David Kay ,  Lee Strnad ,  Dustin Ducharme

IPC: A61B17/58

CPC classification number: A61B17/8635 ,  A61B17/8605 ,  A61B17/863 ,  A61B2017/00004

Abstract: The present invention relates to an orthopedic screw having a torque driving head with spherical surface for multiaxial use, a self starting, self tapping insertion tip and a threaded portion including a modified cancellous thread. The threaded portion has a major diameter defined by a spiraling thread and a minor diameter. The head is joined to the threaded portion by an area of from about 2 to about 6 turns of the thread along the longitudinal axis in which the minor diameter tapers by an angle of from about 4 to about 12° and the major diameter of the screw remaining substantially the same meaning that the major diameter is constant to about +/−0.05 mm along the length of the threaded portion. The screw includes a multilobe torque driving recess joined to a cylindrical recess that corresponds to a cylindrical post on the torque driver so as to form a press fit which acts to self-center the screw, to help avoid stripping of the screw/driver interface and to hold the screw in place on the torque driver prior to implantation. In a further embodiment, the screw includes a variable pitch portion for about half of the length starting from the distil end. The screw can be used be itself, or with a plate. Further a new method of using the screw with a plate is presented in which the screw extends through a cortical section of bone into a cancellous portion but not through the adjacent cortical.

Abstract translation: 本发明涉及具有用于多轴使用的具有球面的扭矩驱动头的自动螺丝，自启动，自攻丝插入尖端和包括修改的松质线的螺纹部分。 螺纹部分具有由螺旋螺纹和较小直径限定的大直径。 头部沿着纵向轴线连接到螺纹部分约2至约6圈的螺纹区域，其中小直径锥度约4至约12度的角度和螺杆的大直径 保持与螺纹部分的长度大致相同的意思，即长径大约为+/- 0.05mm。 所述螺杆包括多个转矩驱动凹部，所述多叶扭矩驱动凹部接合到对应于所述扭矩驱动器上的圆柱形柱的圆柱形凹部，以便形成用于使所述螺钉自对中心的压配合，以有助于避免螺钉/驱动器接口的剥离， 在植入前将螺丝固定在扭矩驱动器上。 在另一实施例中，螺杆包括从蒸馏端开始的大约一半长度的可变节距部分。 螺钉可以自己使用，也可以用于板材。 还提出了使用具有板的螺钉的新方法，其中螺钉通过骨的皮质部分延伸进入松质部分而不通过相邻的皮层。

公开(公告)号：US07074782B2

公开(公告)日：2006-07-11

申请号：US10645043

申请日：2003-08-21

Applicant: David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

Inventor： David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

IPC: C07D223/18 ,  C07D279/36 ,  C07D405/00 ,  C07D221/12 ,  A61K31/55

CPC classification number: C07D403/12 ,  C07D209/08 ,  C07D209/86 ,  C07D221/12 ,  C07D223/26 ,  C07D223/28 ,  C07D279/30

Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1β secretion.

Abstract translation: 本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R 1是氢，-CHN 2，R 2，CH 2 OR，CH 2 SR或-CH 2 Y; Y是电负离子团; R 2是CO 2 H，CH 2 CO 2 H，或它们的酯，酰胺或等体醇; R 3是能够适应半胱天冬酶的S2亚位点的基团; R 4和R 5与间插氮一起形成杂环，R如说明书中所述。 这些化合物是凋亡和IL-1β分泌的有效抑制剂。

公开(公告)号：US06989385B2

公开(公告)日：2006-01-24

申请号：US10026967

申请日：2001-12-19

Applicant: David Bebbington ,  Jean-Damien Charrier ,  Robert Davies ,  Simon Everitt ,  David Kay ,  Ronald Knegtel ,  Sanjay Patel

Inventor： David Bebbington ,  Jean-Damien Charrier ,  Robert Davies ,  Simon Everitt ,  David Kay ,  Ronald Knegtel ,  Sanjay Patel

IPC: C07D403/12 ,  A61K31/517 ,  A61K31/519

CPC classification number: C07D403/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

Abstract: This invention describes novel pyrazole compounds of formula IIc: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

Abstract translation: 本发明描述了式IIc的新的吡唑化合物：其中R 1是T环D，其中环D是5-7元单环或8-10元双环，其选自芳基，杂芳基， 杂环基或碳环基; R x和R y与它们的插入原子一起形成具有0-3个杂原子的稠合的，不饱和的或部分不饱和的5-7元环; 和R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。

公开(公告)号：US06724324B1

公开(公告)日：2004-04-20

申请号：US09643236

申请日：2000-08-21

Applicant: David Kay Lambert

Inventor： David Kay Lambert

IPC: H03K1794

CPC classification number: H03K17/955 ,  E05F15/46 ,  E05Y2900/50 ,  H03K2217/960765 ,  H03K2217/960775

Abstract: A capacitive sensor including a first electrode that has at least one conducting surface being disposed for receiving an alternating current signal, and a second electrode that has at least one conducting surface being disposed to generate an input signal for a detecting device. The sensor further includes a middle electrode that has at least one conducting surface placed between the first electrode and the second electrode, as well as being grounded to a ground. The at least one conducting surface of the middle electrode, the at least one conducting surface of the first electrode, and the at least one conducting surface of the second electrode are contained within a holding material holding within itself the first electrode, the second electrode and the middle electrode.

Abstract translation: 一种电容传感器，包括具有设置用于接收交流信号的至少一个导电表面的第一电极和具有至少一个导电表面的第二电极，该至少一个导电表面设置成产生检测装置的输入信号。 传感器还包括中间电极，该中间电极具有放置在第一电极和第二电极之间的至少一个导电表面，以及接地到地面。 中间电极的至少一个导电表面，第一电极的至少一个导电表面和第二电极的至少一个导电表面包含在保持材料内，其内部保持有第一电极，第二电极和 中间电极。