公开(公告)号：US11956605B2

公开(公告)日：2024-04-09

申请号：US17778637

申请日：2020-11-19

Applicant: Centre National de la Recherche Scientifique ,  Institut de Recherche et de Coordination Acoustique/Musique ,  Sorbonne Université

Inventor： Thomas Helie ,  Tristan Lebrun

IPC: H04R3/00 ,  H04R3/02

CPC classification number: H04R3/02

Abstract: The present invention relates to a device (40) for generating a control signal for an electrical system (S), comprising:



an analog block (46) connected to the input (42) and to the output (44) of the generation device (40), the analog block (46) comprising an electrical circuit comprising a passive analog component, a measuring component and a generator,
a digital block (50) comprising at least one digitally controllable component (70),
the passive analog component of the electrical circuit being configured so as to generate the first component of the control signal and the generator of the electrical circuit being configured so as to generate the second component of the control signal, the electrical circuit being configured so as to sum the first and the second component that are generated in order to obtain the control signal.

公开(公告)号：US20230414700A1

公开(公告)日：2023-12-28

申请号：US18031251

申请日：2021-10-14

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE PARIS ,  SORBONNE UNIVERSITÉ ,  UNIVERSITÉ DE LILLE ,  ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)

Inventor： Séverine LETUVE ,  Céline SALLON ,  Loïc GUILLOT ,  Catherine ROBBE MASSELOT ,  Camille TAILLE

IPC: A61K38/07 ,  A61K45/06 ,  A61P11/12

CPC classification number: A61K38/07 ,  A61P11/12 ,  A61K45/06

Abstract: In asthma, modification of gel-forming respiratory mucins leading to their tethering to the apical pole of epithelial cells, are believed to participate in airway obstruction by mucus plugs. These changes have been linked to local production of Th2 cytokines, resulting in mucus cell hyperplasia and increased MUC5AC production. The inventors showed that severe eosinophil asthma was associated with overexpression of transglutaminase 2 (TG2), an enzyme recently involved in intestinal mucin reticulation. Moreover, the bronchial epithelium from asthmatic patients or control subjects was reconstituted in vitro by culturing cells at the air-liquid interface and the hypersecretory differentiation was modeled by exposing control bronchial epithelial to IL-13. The inventors showed TG2 expression was upregulated upon IL-13-mediated hypersecretory differentiation and correlated with MUC5AC expression. IL-13 promoted MU5AC tethering to in vitro reconstituted hypersecretory epithelium, and this was blocked by a TG2 inhibitor. In conclusion, the inventors showed that TG2 participates in respiratory mucin modifications in asthma, and contribute to mucus tethering to the airway wall, supporting the use of TG2 inhibitors for improving mucociliary clearance in asthma, but more generally in respiratory diseases.

公开(公告)号：US11723988B2

公开(公告)日：2023-08-15

申请号：US16756988

申请日：2018-10-22

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  SORBONNE UNIVERSITÉ

Inventor： Deniz Dalkara ,  Hanen Khabou ,  José-Alain Sahel ,  Thierry Leveillard ,  Jens Duebel

IPC: A61K48/00 ,  A61P27/02 ,  C12N15/86

CPC classification number: A61K48/0058 ,  A61K48/0075 ,  A61P27/02 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2830/008

Abstract: Several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea are provided. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector comprising a VP1 capsid protein as set forth in SEQ ID NO: 11 and the polynucleotide of interest under the control of the pR1.7 promoter as set forth in SEQ ID NO: 12 are also provided.

公开(公告)号：US20230175273A1

公开(公告)日：2023-06-08

申请号：US17997766

申请日：2021-05-07

Applicant: PARIS SCIENCES ET LETTRES ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA DE PARIS ,  SORBONNE UNIVERSITÉ ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS CITE

Inventor： José BICO ,  Emmanuel SIEFERT ,  Benoît ROMAN ,  Etienne REYSSAT

IPC: E04G11/04 ,  A47C27/10 ,  A61G7/057 ,  E04H4/10

CPC classification number: E04G11/045 ,  A47C27/10 ,  A61G7/05769 ,  E04H4/103 ,  E04H2015/204

Abstract: The present invention relates to a pneumatic structure (10) comprising an inextensible body (12) defining at least a network of internal cavities (14), each cavity having a closed contour in at least one section of the cavity
Each cavity being suitable for being pressurized so as to change the inextensible body from a rest configuration to at least one pressurized configuration,
Inextensible body having, in each pressurized configuration, a macroscopic metric different from its macroscopic metric in the rest configuration,
Each cavity being formed of at least two substantially rectilinear channels, each channel being fluidly connected to at least one of the other channels, the two said channels forming a heading change angle,
Each cavity comprising at least one non-zero heading change angle, in particular at least three non-zero heading change angles.

公开(公告)号：US20230021489A1

公开(公告)日：2023-01-26

申请号：US17787205

申请日：2020-12-14

Applicant: UNIVERSITÉ DE LILLE ,  CENTRALE LILLE INSTITUT ,  UNIVERSITÉ POLYTECHNIQUE HAUTS-DE-FRANCE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  YNCREA HAUTS DE FRANCE ,  SORBONNE UNIVERSITÉ

Inventor： Michaël BOUDOIN ,  Jean-Louis THOMAS ,  Antoine RIAUD ,  Olivier BOUMATAR

IPC: B01L3/00 ,  B06B1/02 ,  B06B1/06

Abstract: Electroacoustic device (5) for generating at least one acoustic wave (Fv,Vx), the device comprising a piezoelectric substrate (10) and first (15) and second (20) groups of electrodes (60,65,70,75) arranged on the substrate, each electrode of the first and second groups comprising a track (80a-f,85a-f,90a-d,95a-d), the tracks (90a-d,95a-d) of the electrodes of the first group spiralling around a same spiral axis (Z) along a first winding direction (W1), and the tracks (80a-f,85a-f) of the electrodes of the second group spiralling around said spiral axis along a second winding direction (W2) opposite to the first winding direction.

公开(公告)号：US20220054493A1

公开(公告)日：2022-02-24

申请号：US17434535

申请日：2020-03-06

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE ROUEN-NORMANDIE ,  GREENPHARMA ,  UNIVERSITE DE PARIS ,  SORBONNE UNIVERSITÉ

Inventor： Frédéric JAISSER ,  Ernesto MARTINEZ-MARTINEZ ,  Paul MULDER ,  Antoine OUVRARD-PASCAUD ,  Philippe BERNARD ,  Quoc Tuan DO

IPC: A61K31/519 ,  A61K31/4245 ,  A61K31/415

Abstract: This invention relates to compounds that are inhibitors of NGAL activity, and applications thereof.

公开(公告)号：US20220011323A1

公开(公告)日：2022-01-13

申请号：US17294007

申请日：2019-11-14

Applicant: ASSISTANCE PUBLIQUE -HÔPITAUX DE PARIS ,  SORBONNE UNIVERSITÉ

Inventor： Olivier BOURRON ,  Joe-Elie SALEM ,  Agnès HARTEMANN

IPC: G01N33/68

Abstract: The present invention relates to MGP as a new serum marker useful by itself or in combination with other markers for diagnosis of peripheral neuropathies, in particular in diabetic patients. The invention is also drawn to diagnosis kits for the implementation of this method.

公开(公告)号：US11220702B2

公开(公告)日：2022-01-11

申请号：US14504893

申请日：2014-10-02

Applicant: Centre National de la Recherche Scientifique ,  Sorbonne Université

Inventor： Jérôme Bibette ,  Pascal Panizza ,  Nicolas Bremond ,  Fabien Bertholle ,  Jean Marie Baudry ,  Larysa Baraban ,  Laurent Boitard

IPC: C12Q1/02

Abstract: A method for monitoring a reaction and a reaction system are provided. The reaction system includes at least one vessel for the reaction medium, which is in fluid communication with an injection tube; at least one vessel for a carrier fluid that is immiscible with the reaction medium, which is in fluid communication with a reaction tube; the injection tube being mounted so as to lead into the reaction tube such that individual drops of the reaction medium can be injected into the reaction tube and into the immiscible carrier fluid, so as to form a train of reaction chambers; at least one detector for monitoring a reaction; a means for classifying the reaction chambers; and at least one means for recirculating reaction chambers in front of at least one detector for monitoring a reaction.

公开(公告)号：US20220000454A1

公开(公告)日：2022-01-06

申请号：US17293681

申请日：2019-11-14

Applicant: ROBEAUTE ,  SORBONNE UNIVERSITÉ ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Bertrand DUPLAT ,  Quentin FRANCOIS ,  Sinan HALIYO ,  Régis MARCHIANO ,  Stéphane REGNIER

IPC: A61B8/08 ,  A61B8/00 ,  A61B34/30 ,  G06T7/00 ,  G06T7/30

Abstract: This system for real-time localization of a millimetric or submillimetric object, such as a microrobot, in a viscoelastic medium, in particular in an organ of a subject such as a brain, a liver or a pancreas, includes: at least one bubble configured to be attached to said object, the or each bubble having a hermetic envelope filled with a gas; at least one ultrasound transducer configured to emit initial ultrasound signals and to detect deflected ultrasound signals deflected at the surface of the bubble(s); a processing unit in communication with the ultrasound transducers and configured to generate localization data of the object from localization data of the bubble(s) based on the deflected ultrasound signals detected by the ultrasound transducers.

公开(公告)号：US20210234238A1

公开(公告)日：2021-07-29

申请号：US17154771

申请日：2021-01-21

Applicant: SYMBIO ,  COLLEGE DE FRANCE ,  Sorbonne Université ,  Centre national de la recherche scientifique

Inventor： Christophe VACQUIER ,  Nathalia ROVIRA ,  Christophe BAVEREL ,  Christel LABERTY-ROBERT ,  Laura COUSTAN ,  Clément SANCHEZ

IPC: H01M50/497 ,  H01M50/426 ,  H01M50/403 ,  H01M50/449

Abstract: The present application relates to a proton exchange membrane for fuel cell, said membrane having self-regenerating properties, to cells comprising said membranes, and to the manufacturing method thereof via electrospinning.