公开(公告)号：US20230200974A1

公开(公告)日：2023-06-29

申请号：US18089817

申请日：2022-12-28

Applicant: Yonsei University Industry Foundation (Yonsei UIF) ,  The Catholic University of Korea Industry-Academic Cooperation Foundation ,  Industry Academic Cooperation Foundation of Yeungnam University ,  Chung Ang University Industry Academic Cooperation Foundation

Inventor： Jong Baeg KIM ,  U Syn HA ,  Jin Ho KIM ,  Jung Wook CHOI ,  Won Gun KOH ,  Gyu Jun CHOI ,  Min Hyeong KIM ,  Won Keun PARK ,  Jeong Hyeop SON

IPC: A61F2/04 ,  G01L9/00

CPC classification number: A61F2/042 ,  G01L9/0072 ,  A61F2250/0013 ,  A61F2250/0002

Abstract: The present invention relates to an artificial bladder system having a double space divided by a partition wall and a wireless, non-powered urine fullness sensor using an RFID technology, which provides an artificial bladder system comprising: an outer wall that forms the outer shape of the artificial bladder, is inserted into the body, and has an inner space; a partition wall, wherein both ends are fixed to the inside of the outer wall, the inner space of the outer wall is divided into a double space of a urine reservoir and a working fluid space, and it is deformable according to amounts of the urine and the working fluid; and a urine fullness sensor installed in the working fluid space and sensing a urine fullness degree based on the deformation of the partition wall.

公开(公告)号：US20220361891A1

公开(公告)日：2022-11-17

申请号：US17630298

申请日：2021-07-29

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sa Jin KIM ,  Jae Eun SHIN

IPC: A61B17/12 ,  A61M25/10

Abstract: A hemostatic device is disclosed. The hemostatic device according to an embodiment of the present invention includes: a balloon which is expanded by a fluid supplied therein; a blood discharge pipe which includes a blood inflow hole at one end and exposes the other end to a lower side of the balloon wherein a certain section of a lower side of the blood inflow hole is surrounded by the balloon; and a fluid flow pipe communicating with the inside of the balloon for supplying or discharging the fluid and extending to a lower side of the balloon. The balloon includes a plurality of protrusions that are formed to protrude outward when the balloon is expanded by the fluid.

公开(公告)号：US20220265917A1

公开(公告)日：2022-08-25

申请号：US17627228

申请日：2020-07-03

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyunjung KOH

IPC: A61M5/142 ,  A61M5/315 ,  A61M5/145

Abstract: The present invention relates to an apparatus for patient-controlled drug injection having a counter capable of counting the number of administrations. According to one aspect of the present invention, disclosed is an apparatus for patient-controlled drug injection having a counter, comprising: a case; a pressing part, provided in the case, for applying pressure to pump a chemical liquid; and a counter, provided in the case and having a counting button that is pressed by pressure when a user presses the pressing part, for counting the number of times that the pressing part is pressed.

公开(公告)号：US20220257365A1

公开(公告)日：2022-08-18

申请号：US17610132

申请日：2020-03-20

Applicant: T&R BIOFAB CO., LTD. ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Da Mi CHOI ,  Jeong Seok LEE ,  Jin Hyung SHIM ,  Won Soo YUN ,  Jung Ho LEE

IPC: A61F2/12 ,  A61F2/00 ,  A61L27/14 ,  A61L27/56 ,  B29C64/118 ,  B29C64/209

Abstract: The present invention relates to: an implant for the reconstruction of the nipple-areola complex; and a method for producing same. The implant for the reconstruction of the nipple- areola complex according to the present invention can be implanted along a central axis inside autologous tissue during nipple-areola complex reconstruction surgery to form a normal nipple-areola complex shape. In addition, the nipple-areola complex implant according to the present invention, due to being formed of a porous structure, has similar flexibility to normal nipple-areola complex tissue, and exhibits a high engraftment rate with autologous tissues since the surrounding tissue can permeate into the implant through the voids thereof following implantation.

公开(公告)号：US20220233700A1

公开(公告)日：2022-07-28

申请号：US17617000

申请日：2020-05-25

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Hwan NAM ,  Gyo Chang KEUM ,  Hyo Jung PARK ,  Eun Kyoung BANG ,  Hae Li KO

IPC: A61K47/24 ,  A61K39/39 ,  A61K39/215 ,  C12N7/00 ,  C12N15/86 ,  A61K39/145 ,  A61P31/16 ,  A61K39/12 ,  A61P31/14

Abstract: The present disclosure relates to a pharmaceutical composition comprising a nucleic acid molecule of an adjuvant, a metal complex stabilizing the nucleic acid molecule, and optionally an immunogen that may be a peptide or a protein, or a composition of stabilizing the nucleic acid molecule of the adjuvant comprising the metal complex. The metal complex interacts with the nucleic acid molecule of the adjuvant and/or the immunogen so as to stabilize such pharmaceutically active ingredients, and induces continuous effectiveness of the active ingredients without degradation.

公开(公告)号：US20220229060A1

公开(公告)日：2022-07-21

申请号：US17646179

申请日：2021-12-28

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yeong Jin CHOI

IPC: G01N33/574 ,  C12Q1/6886

Abstract: The present invention relates to markers for diagnosing the difference in effects of renal cancer treatment or the prognosis of renal cancer patients, according to the gender of renal cancer patients. The survival rate and recurrence rate of renal cancer of a particular gender respectively relate to the mutation of genes, of the present invention, in renal cancer patients, and thus the mutated genes of the present invention can be used as markers in predicting, on the basis of gender, the difference in effects of renal cancer treatment or the prognosis of renal cancer patients.

公开(公告)号：US20220142782A1

公开(公告)日：2022-05-12

申请号：US17419446

申请日：2019-12-20

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sang Hwa LEE ,  Joo Yup LEE

IPC: A61F2/30

Abstract: A customized artificial temporomandibular joint unit according to an embodiment of the present disclosure includes a first plate provided along a lower line of a lower jawbone forming a temporomandibular joint and having an insertion groove that is outwardly open, a second plate provided at a temporal bone forming the temporomandibular joint together with the lower jawbone, and a main prothesis detachably combined to the first plate without a separate fastening device by being forcibly fit into the insertion groove while approaching the first plate, and arranged in a customized manner at a facing surface location facing the second plate.

公开(公告)号：US20210401319A1

公开(公告)日：2021-12-30

申请号：US17294545

申请日：2019-11-13

Applicant: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Dong In OH ,  Eung Je WOO ,  Dong Choon PARK ,  Seung Geun YEO

IPC: A61B5/0536 ,  A61B1/04 ,  A61B5/0538 ,  A61B5/00 ,  A61B1/00

Abstract: Disclosed are a screening apparatus using a multi-channel array electrode probe and a method of operating the screening apparatus, wherein the screening apparatus includes a probe inserted into the inside of the human body and including a plurality of electrodes in contact with any one portion of the inside and an endoscope camera for photographing the portion; a location identifier for identifying a location in contact with the electrodes in an image photographed by the endoscope camera; an electrical property measuring device for measuring the electrical properties of the identified location; a mapping processor for mapping the measured electrical properties to an electrical model for the internal tissue; and a visualization information generator for, based on the mapping results, generating visualization information for visualization of the degree of deformation of the tissue with respect to the measured electrical properties.

公开(公告)号：US11028428B2

公开(公告)日：2021-06-08

申请号：US15775591

申请日：2016-06-03

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yonggoo Kim ,  Myungshin Kim ,  Joonhong Park ,  Minsik Song ,  Heekyung Park ,  KyungTak Kim

IPC: C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6886

Abstract: The present invention provides a peptide nucleic acid probe including any one or more selected from the group consisting of nucleic acid sequences represented by SEQ ID NOs: 7-10 and nucleic acid sequences complementary to the nucleic acid sequences, and manufactured so as to complementarily bind to a BCR/ABL negative myeloproliferative neoplasm-associated gene, thereby enabling multiplex detection of gene mutations; a composition for multiplex detection of gene mutations comprising the same; a kit; and a method for multiplex detection of BCR/ABL negative myeloproliferative neoplasm-associated gene mutations using the same. Therefore, since multiplex detection of BCR/ABL negative myeloproliferative neoplasm-associated gene mutations can be rapidly and accurately carried out by one detection process, BCR/ABL negative myeloproliferative neoplasm is effectively diagnosed, and thus the present invention can be useful for diagnosis, follow-up, prognosis estimation, and treatment of diseases.

公开(公告)号：US10851346B2

公开(公告)日：2020-12-01

申请号：US14912391

申请日：2014-08-14

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Chul Woo Yang ,  Mi-La Cho ,  Sung-Hwan Park ,  Eun Kyung Kim ,  Byung Ha Chung ,  Kyoung-Woon Kim ,  Seon-Yeong Lee ,  Sung-Hee Lee ,  Eun Ji Yang ,  Jeong-hee Jeong ,  Min Jung Park ,  Seok-Jung Kim ,  Eun-Jung Lee ,  Su-Jin Moon

IPC: C12N5/0775 ,  C07K14/715 ,  A61K38/17 ,  A61K35/28

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-β and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII. If this cell is used as a cell therapy in individuals having immune disorders, it is possible to effectively treat immune disorders.