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公开(公告)号：US10365900B2
公开(公告)日：2019-07-30
申请号：US14968296
申请日：2015-12-14
摘要： Three extensions to the conventional field specialization process are disclosed. The first extension is cross-application value flows, where a value transfers out of one application and subsequently into another application. The second extension is an inter-application analysis. Static and dynamic analysis is performed by a Spiff Toolset not just on the source code of a single application, but also across the data read and written by that application. The third extension is invariant cross-application termination, verifying the possibility of an invariant originating in an application and terminating in a specialization opportunity in a separate application. An ecosystem specification is disclosed to enable such field specialization broadening. This specification states which applications are involved, what input data sources are read, what intermediate and final data products are produced, and what services are invoked, thereby providing valuable information on how intermediate results are communicated among the various applications.
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![[3+2] annulation to produce 5-membered heterocyclic compounds](/abs-image/US/2019/07/23/US10358438B2/abs.jpg.150x150.jpg)
公开(公告)号：US10358438B2
公开(公告)日：2019-07-23
申请号：US15329615
申请日：2015-07-20
IPC分类号： C07D405/04 , C07D209/42 , C07D207/48 , C07D207/18 , C07D207/277 , C07D209/12
摘要： The present invention relates to various organic reactions including a method for producing heterocyclic compounds using a [3+2] annulation; a method for producing fluorinated heteroaromatic compounds; and a method for alkylating a meta-position of a phenolic compound.
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公开(公告)号：US20190123417A1
公开(公告)日：2019-04-25
申请号：US16227862
申请日：2018-12-20
申请人： The Arizona Board of Regents on Behalf of the University of Arizona , Southwest Research Institute
摘要： A balloon reflector antenna for a satellite, including a spherical balloon with a surface transparent to electromagnetic waves and a reflective surface opposite the transparent surface. The balloon reflector antenna may further include a feed system extending from the center of the balloon that receives electromagnetic waves reflected off the reflective surface and/or outputs electromagnetic waves that are reflected off the reflective surface.
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公开(公告)号：US20190109558A1
公开(公告)日：2019-04-11
申请号：US16154394
申请日：2018-10-08
发明人： Moe Momayez , Nathan Barba
摘要： Disclosed are modular floating platforms configured to be joined together to form a cover over surfaces of natural and artificial bodies of water and other liquids, for reducing evaporation and other purposes. The floating platforms may be motorized and provided with remote control systems, so that the platforms may be assembled together on command to provide uniform coverage of the surface of the body of water. The floating platforms are optionally capable of solar and wind power collection. The platforms are useful for covering mining tailing storage ponds.
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85.发明授权公开(公告)号：US10226552B2
公开(公告)日：2019-03-12
申请号：US14781843
申请日：2014-04-04
发明人： Marvin J. Slepian
IPC分类号： A61L31/16 , A61L31/14 , A61F2/945 , A61B5/00 , A61B5/026 , A61B5/07 , A61N1/32 , A61N1/372 , A61B5/0215 , A61F2/82 , A61L31/04 , A61B5/01 , A61B5/11 , A61B5/145 , A61B8/06 , A61B8/12 , A61B8/08
摘要： Methods, materials, devices, and systems for electropolymeric paving and sealing (ePEPS) are provided. The methods include delivering paving materials to an interior surface of a blood vessel, tissue lumen or other hollow space, delivering electronic components to the surface, and forming a conformal device that contains the paving material and the integrated electronic components. Integrated electronic components can be homogenously or heterogeneously distributed in the material, such as on the top, middle, and/or bottom of the polymeric material. The devices are biocompatible, and preferably biodegradable or bioerodible. The devices integrated electrical properties useful for sensing or detecting one or more analytes, signals or conditions, transmitting or generating a signal, or releasing a therapeutic, prophylactic or diagnostic agent. Optionally, the devices are smart devices that include feedback and logic means to respond to a change in local conditions.
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公开(公告)号：US10219052B2
公开(公告)日：2019-02-26
申请号：US15692914
申请日：2017-08-31
申请人： The Arizona Board of Regents on Behalf of the University of Arizona , Futurewei Technologies, Inc.
发明人： Jiafeng Zhu , Jun He , Likun Lin , Weiyang Mo , Saied Agahi , John Wissinger
IPC分类号： H04Q11/00 , H04J14/02 , H04B10/079 , H04L12/721
摘要： An embodiment method for managing connections on a communications network having an optical network portion includes receiving a request for a first connection at a controller in signal communication with one or more reconfigurable optical add-drop multiplexers (ROADMs) controlling an optical network portion of a communications network, wherein the controller is connected to the communications network. The controller determines a route on the communications network for the first connection according to conditions of the communications network, with the route comprising one or more first links of the optical network. The controller determines one or more first ROADMs controlling the one or more first links and sends commands from the controller to the one or more first ROADMs to allocate bandwidth on the one or more first links.
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公开(公告)号：US20190038584A1
公开(公告)日：2019-02-07
申请号：US15904153
申请日：2018-02-23
申请人： The Arizona Board of Regents on Behalf of the University of Arizona , The Regents of the University of California, a California Corporation
发明人： Eugene W. GERNER , Jason A. ZELL , Christine E. MCLAREN , Frank L. MEYSKENS, Jr. , Hoda ANTON-CULVER , Particia A. THOMPSON
IPC分类号： A61K31/198 , G01N33/574 , C12Q1/6886 , A61K31/192 , A61K31/415
摘要： The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.
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公开(公告)号：US20190017729A1
公开(公告)日：2019-01-17
申请号：US15748792
申请日：2016-08-03
IPC分类号： F24S23/77 , F24S20/20 , F24S23/70 , F24S25/13 , F24S30/452
CPC分类号： F24S23/77 , F24S20/20 , F24S23/70 , F24S23/82 , F24S25/13 , F24S25/50 , F24S30/452 , F24S2023/872 , F24S2030/145 , Y02E10/41 , Y02E10/47
摘要： A solar concentrator may have a horizontal circular track on the ground, a tower centered on a vertical axis of the track, and a rotatable structure around the track having an upper, concave mounting surface approximating the shape of part of a sphere centered on the top of the tower. Articulated concave mirrors are attached to the rotatable structure, and the mirrors have a focal length approximately equal to the radius of a sphere portion formed by the concave mounting surface. Sunlight is focused at a receiver mounted atop the tower, and the receiver may convert sunlight into thermal or electrical energy. As the position of the Sun changes, sunlight is maintained on the receiver by turning the rotatable structure toward the Sun, turning the receiver about said vertical axis to face the mirrors, and articulating the mirrors toward the receiver in response to the changing elevation of the Sun.
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公开(公告)号：US20180245177A1
公开(公告)日：2018-08-30
申请号：US15758655
申请日：2016-06-29
CPC分类号： C22B11/044 , C22B3/00 , C22B3/02 , C22B4/00 , C22B4/08 , C22B7/04 , C22B11/04 , C22B15/0065 , C25C3/00 , C25C3/34 , C25C7/025 , Y02P10/234 , Y02P10/236
摘要： A method for the electrolytic production of pure copper from copper-containing compounds dissolved in a high-temperature bath of molten salts which function as an electrolyte in an electrolytic cell. An electric current is passed between an anode immersed in the copper-ion rich molten salt bath and a cathode or cathode-lined kettle in which the molten salt bath is contained, thereby reducing the dissolved copper ions to form pure molten copper. The deposited molten copper collects at the bottom of the kettle and can be separated from the molten salt bath using conventional means.
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公开(公告)号：US20180244678A1
公开(公告)日：2018-08-30
申请号：US15753513
申请日：2016-08-16
发明人： Eric WETERINGS , Daruka MAHADEVAN , Josef VAGNER
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61P35/00
CPC分类号： C07D487/04 , A61K31/496 , A61K31/519 , A61K31/55 , A61K45/06 , A61P35/00 , C07D413/12
摘要： Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
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