公开(公告)号：US20210230219A1

公开(公告)日：2021-07-29

申请号：US17063158

申请日：2020-10-05

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF SOUTH FLORIDA

发明人： David L. Morse ,  Josef Vagner ,  Mark McLaughlin ,  Robert Gillies ,  Amanda Huynh ,  Michael Doligalski

IPC分类号： C07K5/083 ,  A61K49/00 ,  A61K51/04

摘要： Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

公开(公告)号：US11059880B2

公开(公告)日：2021-07-13

申请号：US15738467

申请日：2016-06-29

申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  JOSLIN DIABETES CENTER, INC.

发明人： Michael S. Kuhns ,  Thomas Serwold

IPC分类号： C07K14/74 ,  C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/12

摘要： Chimeric receptors featuring major histocompatibility molecules grafted onto T cell receptor molecules and surrogate co-receptors featuring cell surface receptor ligands fused with signaling molecule domains. The chimeric receptors can be used to redirect cells, altering their specificity. T cells expressing chimeric receptors may bind to ICRs of target T cells for which their chimeric receptors are specific. Surrogate co-receptors may be used to help enhance TCR-CD3 signaling as part of this modular receptor system. The chimeric receptors and surrogate coreceptors may be used to help eliminate autoreactive T cells or program T cells to desired effector functions.

公开(公告)号：US10907001B2

公开(公告)日：2021-02-02

申请号：US15760830

申请日：2016-09-19

申请人： The Arizona Board of Regents on Behalf of The University of Arizona ,  Arthur J. Coury

发明人： Arthur J. Coury ,  Marvin J. Slepian

IPC分类号： C08G75/02 ,  C08G75/20 ,  C08F228/02 ,  C08G85/00 ,  C08G81/00 ,  C08G75/23 ,  C08G75/0286 ,  C08L81/00 ,  C08G75/00 ,  A61L27/16 ,  A61L29/04 ,  A61L31/04 ,  C08F236/04 ,  C08F299/02 ,  C08K5/41 ,  C08G75/04 ,  C08G75/045 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16

摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.

公开(公告)号：US10901128B2

公开(公告)日：2021-01-26

申请号：US15739680

申请日：2016-06-24

申请人： The Arizona Board of Regents on Behalf of the University of Arizona

发明人： Stanley Pau ,  Russell Chipman ,  Wei-Liang Hsu

IPC分类号： G02B5/30 ,  G02F1/1335

摘要： Compound dichroic polarizers (CDPs) include multiple component dichroic polarizers based on different dichroic dyes and oriented to have different eigenpolarization directions. The component dichroic polarizers can be fixed to each other or to a substrate such as an eyeglass lens. Selection of eigenpolarization orientation and spectrum in a CDP permits color encoding of different SOPs.

公开(公告)号：US10793595B2

公开(公告)日：2020-10-06

申请号：US16150496

申请日：2018-10-03

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF SOUTH FLORIDA

发明人： David L. Morse ,  Josef Vagner ,  Mark McLaughlin ,  Robert Gillies ,  Amanda Huynh ,  Michael Doligalski

IPC分类号： A61K49/00 ,  C07K5/083 ,  A61K51/04

摘要： Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

公开(公告)号：US10772722B2

公开(公告)日：2020-09-15

申请号：US15492227

申请日：2017-04-20

申请人： The Research Foundation for The State University of New York ,  The Arizona Board of Regents on Behalf of the University of Arizona

发明人： Danny Bluestein ,  Thomas E. Claiborne ,  Marvin J. Slepian

IPC分类号： A61F2/24

摘要： A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.

公开(公告)号：US10718889B2

公开(公告)日：2020-07-21

申请号：US16299066

申请日：2019-03-11

申请人： The Arizona Board of Regents on Behalf of the University of Arizona

发明人： Stanley Pau ,  Wei-Liang Hsu

IPC分类号： G02B5/30 ,  G01J4/04 ,  C09K19/38 ,  C09K19/56 ,  G02F1/1337 ,  G02F1/1335 ,  G01J4/00

摘要： Exemplary thin-film optical devices have first and second layer groups disposed as a layer stack on a substrate. The first layer group comprises a first PPN layer, a first LCP layer, and a first barrier layer all superposed. The second layer group is superposed relative to the first layer group, and includes a second PPN layer, a second LCP layer, and a second barrier layer all superposed. The first and second layer groups cooperate to polarize multiple wavelengths of an incident light flux in a broadband and/or wide-angle manner Each of the layer groups has an alignment layer, a respective liquid-crystal polymer layer, and a barrier layer.

公开(公告)号：US20200163605A1

公开(公告)日：2020-05-28

申请号：US16691637

申请日：2019-11-22

申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Joseph S. Valacich ,  Jeffrey L. Jenkins

IPC分类号： A61B5/16 ,  G06F21/32 ,  G06F21/31 ,  G06F21/40

摘要： The present invention provides a system and a method for eliciting information to sensitive questions and reliably detecting whether one is being deceptive, concealing information, or experiencing a heightened emotional response to the question. In particular, the system and the method of the invention are based on analyzing the user behavioral biometric of using one or more input device(s).

公开(公告)号：US10551089B2

公开(公告)日：2020-02-04

申请号：US15748792

申请日：2016-08-03

申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Justin J Hyatt ,  Brian M Wheelwright ,  Roger P Angel

IPC分类号： F24S23/77 ,  H01L31/054 ,  F24S23/70 ,  F24S20/20 ,  F24S25/13 ,  F24S30/452 ,  F24S30/00

摘要： A solar concentrator may have a horizontal circular track on the ground, a tower centered on a vertical axis of the track, and a rotatable structure around the track having an upper, concave mounting surface approximating the shape of part of a sphere centered on the top of the tower. Articulated concave mirrors are attached to the rotatable structure, and the mirrors have a focal length approximately equal to the radius of a sphere portion formed by the concave mounting surface. Sunlight is focused at a receiver mounted atop the tower, and the receiver may convert sunlight into thermal or electrical energy. As the position of the Sun changes, sunlight is maintained on the receiver by turning the rotatable structure toward the Sun, turning the receiver about said vertical axis to face the mirrors, and articulating the mirrors toward the receiver in response to the changing elevation of the Sun.

公开(公告)号：US10514485B2

公开(公告)日：2019-12-24

申请号：US14072443

申请日：2013-11-05

申请人： The Arizona Board of Regents on behalf of The University of Arizona

发明人： Raymond K. Kostuk ,  Shelby D. Vorndran ,  Deming Zhang ,  Juan Manuel Russo ,  Michael Gordon

IPC分类号： G02B5/32 ,  H01L31/052 ,  A01G33/00 ,  G02B19/00 ,  G02B27/10 ,  A01H3/02 ,  C12N1/12 ,  C12N13/00 ,  C12M1/00 ,  H02S40/22 ,  H01L31/054 ,  F24S23/00

摘要： An apparatus for obtaining energy from a polychromatic energy source that emits radiation in a first and a second wavelength band comprises a reflector or an energy receiver having an aperture therein; and a holographic lens that diffracts and focuses the radiation within the first wavelength band from the energy source through said aperture towards a first energy receiver, and transmits the radiation within the second wavelength band from the energy source to the reflector or energy receiver. If a reflector is used, the reflector reflects the radiation transmitted by the holographic lens towards a second energy receiver.