公开(公告)号：US20160152610A1

公开(公告)日：2016-06-02

申请号：US14900248

申请日：2014-06-27

申请人： ALZPROTECT ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Patricia MELNYK ,  Pascal CARATO ,  Stephane BURLET ,  Emilie NGUYEN ,  Philippe VERWAERDE ,  Nicolas SERGEANT ,  Cecilia ESTRELLA

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.

摘要翻译： 本发明涉及式（A）化合物或其药学上可接受的盐，溶剂化物，包合物，水合物或多晶型物及其用途。

公开(公告)号：US20150246095A1

公开(公告)日：2015-09-03

申请号：US14430405

申请日：2013-10-01

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE I-SCIENCES ET TECHNOLOGIES ,  UNIVERSITE DU DROIT ET DE LA SANTE LILLE 2 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE (CNRS)

发明人： Francois Trottein ,  Stoyan Ivanov ,  Josette Fontaine ,  Christelle Faveeuw

IPC分类号： A61K38/20 ,  C12Q1/68 ,  G01N33/68 ,  A61K45/06

CPC分类号： A61K38/20 ,  A61K38/2066 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6869 ,  G01N2800/26 ,  G01N2800/50 ,  A61K2300/00

摘要： The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza. In particular, the present invention relates to an interleukin 22 (IL-22) polypeptide for use in the prophylactic treatment of bacterial superinfections post-influenza in a subject in need thereof.

摘要翻译： 本发明涉及用于预防性治疗流感后细菌超感染的方法和药物组合物。 特别地，本发明涉及用于在有需要的受试者中预防性治疗流感后细菌超感染的白细胞介素22（IL-22）多肽。

公开(公告)号：US20240238244A1

公开(公告)日：2024-07-18

申请号：US18558870

申请日：2022-05-05

申请人： 4LIVING BIOTECH ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Revital RATTENBACH ,  Keren BISMUTH ,  Jérome BRETON ,  François TROTTEIN ,  Valentin SENCIO

IPC分类号： A61K31/395 ,  A61K45/06 ,  A61P31/16

CPC分类号： A61K31/395 ,  A61K45/06 ,  A61P31/16

摘要： A compound of formula (I) or a pharmaceutically acceptable salt and/or hydrate thereof, for use in the treatment of a viral pulmonary disease or a chronic respiratory distress syndrome (CRDS) resulting from a viral pulmonary disease in a subject, the disease being different from COVID-19, wherein formula (I) is Z—R-A-R′—Y, including plerixafor.

公开(公告)号：US20240180163A1

公开(公告)日：2024-06-06

申请号：US18285314

申请日：2022-04-04

申请人： UNIVERSITE DE LIEGE ,  UNIVERSITE DE LILLE

发明人： Barbara FIFANI ,  Philippe JACQUES ,  Frank DELVIGNE ,  Vincent PHALIP

IPC分类号： A01N63/22 ,  A01N37/44 ,  A01N63/38 ,  A01P1/00 ,  A01P3/00 ,  A01P5/00 ,  A01P7/04 ,  A01P15/00 ,  A01P21/00 ,  C05C5/02

CPC分类号： A01N63/22 ,  A01N37/44 ,  A01N63/38 ,  A01P1/00 ,  A01P3/00 ,  A01P5/00 ,  A01P7/04 ,  A01P15/00 ,  A01P21/00 ,  C05C5/02

摘要： The present disclosure relates to a composition for promoting plants growth and/or for protecting plants against at least one plant pest and/or one plant disease, the composition comprising simultaneously at least one bacteria of the genus Bacillus producing antifungal lipopeptides, at least one fungi of the genus Trichoderma, and at least one nitrogen mineral source. The present disclosure also relates to the use of such a composition and to a method for obtaining such a composition. The present disclosure also relates to a co-culture medium for producing at least in part such a composition.

公开(公告)号：US20240148778A1

公开(公告)日：2024-05-09

申请号：US18550349

申请日：2022-03-15

申请人： LESAFFRE ET COMPAGNIE ,  UNIVERSITÉ CLERMONT AUVERGNE ,  UNIVERSITE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Nathalie BALLET ,  Pascal VANDEKERCKOVE ,  Yann GUERARDEL ,  Shin-Yi YU ,  Adeline SIVIGNON ,  Nicolas BARNICH

IPC分类号： A61K31/716 ,  A61K36/064 ,  A61P31/04

CPC分类号： A61K31/716 ,  A61K36/064 ,  A61P31/04

摘要： A composition of yeast polysaccharides including β(1,6)-glucans, preferably also mannans and α-glucans. The yeast polysaccharides are extracted from yeast cell wall fragments. Typically, the β-glucans are β(1,6)-glucans. Also, a method for obtaining such a composition, including at least one step of fractionating a composition of yeast cell walls and extracting an insoluble fraction, and at least one step of extracting a soluble fraction from the insoluble fraction obtained in step a). Further, a composition with a human or veterinary therapeutic objective, for the treatment of gastrointestinal pathologies associated with pathogenic microorganisms, as well as to its non-therapeutic use for improving intestinal comfort.

公开(公告)号：US11948548B2

公开(公告)日：2024-04-02

申请号：US16969054

申请日：2019-02-08

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE LILLE ,  YNCREA HAUTS DE FRANCE ISEN LILLE

发明人： Arnaud Devos

IPC分类号： G10K15/04

CPC分类号： G10K15/046

摘要： A phonon parametric oscillator is provided. The phonon parametric oscillator comprises a laser for periodically emitting brief optical pulses (IL), an assembly for generating acoustic pulses (IA) and a medium for coupling the acoustic pulses to an object (O), the assembly for generating acoustic pulses comprising an entrance face, an exit face, a conversion medium for converting the brief optical pulses into acoustic pulses and a propagation medium for propagating said acoustic pulses, the entrance and exit faces being reflective to the acoustic pulses, the propagation medium having a defined thickness, the exit face making contact with the coupling medium. In the phonon parametric oscillator according to the invention, the round-trip time of an acoustic pulse due to reflection from the entrance and exit faces, is equal to the emission period (τ) of the laser, so that the reflected acoustic pulse is in phase with the following acoustic pulse.

公开(公告)号：US20240101542A1

公开(公告)日：2024-03-28

申请号：US18267432

申请日：2021-12-17

申请人： UNIVERSITE DE LILLE ,  INSTITUT PASTEUR DE LILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Rebecca DEPREZ POULAIN ,  Ronan GEALAGEAS ,  Virgyl CAMBERLEIN ,  Charlotte TABEY FLEAU ,  Valentin GUILLAUME ,  Damien BOSC ,  Benoit DEPREZ ,  Pierre SIEROCKI

IPC分类号： C07D409/14 ,  A61K45/06 ,  C07D409/12 ,  C07D417/12

CPC分类号： C07D409/14 ,  A61K45/06 ,  C07D409/12 ,  C07D417/12

摘要： The present disclosure relates to novel compounds of formula (I) which are useful as inhibitors of endoplasmic reticulum aminopeptidases (ERAP), in particular as inhibitors of ERAP2. The disclosure also relates to the therapeutic use of these compounds, in particular the use of these compounds in the treatment or prophylaxis of proliferative disorders, autoinflammatory disorders and autoimmune disorders.

公开(公告)号：US20240043626A1

公开(公告)日：2024-02-08

申请号：US18257549

申请日：2020-12-14

申请人： RHODIA OPERATIONS ,  LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE LILLE ,  CENTRALE LILLE INSTITUT

发明人： Dan Wu ,  Vitaly Ordomsky ,  Andrei Khodakov ,  Stephane Streiff ,  Jianxia Zheng

IPC分类号： C08H7/00 ,  B01J23/46 ,  B01J21/18 ,  B01J27/13 ,  B01J21/08 ,  B01J23/44 ,  C07C37/54 ,  C07C1/22

CPC分类号： C08H6/00 ,  B01J23/462 ,  B01J21/18 ,  B01J27/13 ,  B01J21/08 ,  B01J23/44 ,  C07C37/54 ,  C07C1/22

摘要： A method for the selective cleavage of a compound comprising an aromatic ring and a C—O—C linkage in the presence of a heterogeneous catalyst is provided. The heterogenous catalyst may be a supported noble metal catalyst doped with a halogen selected from the group consisting of chlorine and bromine. By using this method, it is possible to increase the selectivity and/or yield (preferably both) of aromatic compounds.

公开(公告)号：US20240023992A1

公开(公告)日：2024-01-25

申请号：US18256115

申请日：2021-12-06

申请人： UNIVERSITE DE LILLE ,  CENTRALE LILLE INSTITUT ,  CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Julien DE JONCKHEERE ,  Olivier MAYEUR ,  Franck GAULTIER ,  Michel COSSON ,  Chrystele RUBOD

IPC分类号： A61B17/44

CPC分类号： A61B17/44 ,  A61B2017/00681

摘要： Disclosed is a device for detecting a pressure, of the type including a detection element on which a pressure is exerted, a transducer connected to the detection element and an elastically deformable shell. The shell is made of biocompatible and sterilizable material, has two opposing walls and an insertion opening, and the detection element includes at least one elastically deformable tube, the tube includes a portion arranged in the shell, the tube is closed at one end and filled with a fluid, the other end of the tube being open, arranged outside the shell and connected to the transducer.

公开(公告)号：US11802836B2

公开(公告)日：2023-10-31

申请号：US16618639

申请日：2018-06-01

申请人： Universite De Lille ,  Centre National De La Recherche Scientifique

发明人： Alexis Vlandas ,  Julien Wengler ,  Sebastien Lamant ,  Vincent Senez

IPC分类号： G01N21/41 ,  G01N21/47 ,  G01N21/45 ,  C12Q1/34 ,  G01N21/55 ,  G01N21/77

CPC分类号： G01N21/4133 ,  C12Q1/34 ,  G01N21/55 ,  G01N21/77

摘要： A process for detecting the sensitivity of one or more polymers and/or of one or more, mixtures of polymers to a compound, including the steps of exposing at least one lens-shaped micro-deposit, including the polymer(s) and/or the mixture(s) of polymers, to the compound, and detecting, by illuminating the surface of this micro-deposit, a change in the spatial distribution of the intensity of the light reflected or transmitted by this micro-deposit, linked to a variation in the dimensions and/or refractive index of this micro-deposit, under the effect of an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.