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公开(公告)号:US20220218790A1
公开(公告)日:2022-07-14
申请号:US17708394
申请日:2022-03-30
Applicant: University of Sheffield
Inventor: Ian Wilkinson , Richard Ross
IPC: A61K38/17 , A61K31/593 , A61K33/10 , A61K38/29 , C07K14/635 , C07K14/72 , C12N15/62
Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.
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公开(公告)号:US11344606B2
公开(公告)日:2022-05-31
申请号:US16608611
申请日:2018-04-27
Applicant: University of Sheffield
Inventor: Ian Wilkinson , Richard Ross
IPC: A61K38/29 , C07K14/635 , C12N15/62 , A61K38/16 , C12N15/63 , A61K38/17 , A61K31/593 , A61K33/10 , C07K14/72
Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.
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公开(公告)号:US20220023281A1
公开(公告)日:2022-01-27
申请号:US17293157
申请日:2019-11-15
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Gareth RICHARDS , Timothy M. SKERRY , Joseph P.A. HARRITY , Jean-Olivier ZIRIMWABAGABO , Matthew J. TOZER , Karl Richard GIBSON , Roderick Alan PORTER , Paul Alan GLOSSOP
IPC: A61K31/4545 , A61P35/00 , C07D471/10 , C07D519/00 , A61K31/496 , A61K31/437 , A61K31/55 , A61K31/439 , A61K45/06 , A61N5/10
Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R1, R2, R3, R4, R5, L, L1, X1, X2, X3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.
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公开(公告)号:US20200160706A1
公开(公告)日:2020-05-21
申请号:US16610715
申请日:2018-05-08
Applicant: The University of Sheffield
Inventor: Alex COPE
Abstract: Examples relate to detectors for determining motion from visual cues, said determining being invariant to changes in at least one of temporal and spatial frequencies of said visual cues.
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公开(公告)号:US20200093957A1
公开(公告)日:2020-03-26
申请号:US16619256
申请日:2018-06-07
Applicant: The University of Sheffield
Inventor: Sheila Macneil , Christopher Reginald Chapple , Sabiniano Roman Regueros , Christopher James Hillary , Anthony James Bullock
Abstract: The present invention relates to a scaffold for the treatment of stress urinary incontinence, wherein the scaffold comprises three layers of polyurethane: a first layer and a third layer in which the polyurethane fibres are randomly orientated and a second layer between said first and third layers in which the fibres are aligned longitudinally; methods of making such scaffolds and uses thereof.
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公开(公告)号:US20190000388A1
公开(公告)日:2019-01-03
申请号:US16065209
申请日:2016-12-21
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Dilichukwu ANUMBA , Timothy James HEALEY
Abstract: An apparatus capable of determining the force applied to the tip of an electrical impedance spectroscopy probe comprises: ⋅an elongate probe comprising a probe tip attached to a handle, the probe tip having a substantially planar distal end for contacting human or animal tissue; ⋅a load cell located in said handle and capable of measuring a force Floadcell applied axially along a longitudinal axis when said probe tip is in contact with said human or animal tissue; ⋅an accelerometer located in the handle for measuring a gravity vector Aaxial; ⋅processing means for compensating for the mass of the probe tip using said measured force and gravity vector to produce a calibrated measurement of force F applied to said probe tip.
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公开(公告)号:US10150946B2
公开(公告)日:2018-12-11
申请号:US14769724
申请日:2014-02-21
Applicant: The University of Sheffield
Inventor: Irene Canton , Steven Peter Armes , Nicholas John Warren , Harry Moore , Giuseppe Battaglia , Denis Cecchin
IPC: C12N5/00
Abstract: The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium. As such, stem cells can be easily captured within a 3D gel matrix by simply mixing the stem cells with the non-gelatinous/fluid form of the medium and then gelling the medium by adjusting the temperature across the gelling temperature of the medium. The stem cells encapsulated within the gelatinous form of the medium may then be preserved for a significant time period before either using the stem cells directly within the medium (e.g. in therapy, or in culturing, differentiation, and such like), or after their extraction from the medium.
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公开(公告)号:US10053476B2
公开(公告)日:2018-08-21
申请号:US14914994
申请日:2014-09-02
Applicant: UNIVERSITY OF SHEFFIELD
Inventor: Richard Jackson , Richmond Muimo , Matthew Lilley
IPC: A61K39/385 , C07F9/6503 , C07F9/6539 , C07K16/44 , G01N33/53 , C07F9/58 , C07F9/6553 , C07K14/00
CPC classification number: C07F9/65031 , C07F9/58 , C07F9/6539 , C07F9/655345 , C07K14/001 , C07K16/44 , G01N33/5308 , G01N2440/14
Abstract: The invention relates to phosphohistidine analogs. The invention also relates to antibodies that specifically bind to the analogs and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analog of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.
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公开(公告)号:US20180214613A1
公开(公告)日:2018-08-02
申请号:US15747410
申请日:2016-07-25
Applicant: The University of Sheffield
Inventor: Aileen Crawford-Corrie , David John Buttle , John William Haycock
Abstract: The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.
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公开(公告)号:US20160254867A1
公开(公告)日:2016-09-01
申请号:US15148873
申请日:2016-05-06
Applicant: STC.UNM , The University of Sheffield
Inventor: Majeed M. Hayat , John P. David , Sanjay Krishna , Luke F. Lester , David A. Ramirez , Payman Zarkesh-Ha
IPC: H04B10/67 , H01L31/0304 , G01J1/44 , H01L31/0735
CPC classification number: H04B10/67 , G01J1/44 , G01J1/46 , G01J2001/4466 , H01L31/02027 , H01L31/0304 , H01L31/03046 , H01L31/0735 , H01L31/109 , H04B10/6911 , H04B10/693
Abstract: Apparatus, systems, and methods relate to use of a time-varying bias for application to an avalanche photodiode. Embodiments include systems and methods of determining an appropriate time-varying bias for application to an avalanche photodiode in linear mode. Avalanche photodiode having appropriate parameters may also be determined. Additional apparatus, systems, and methods are disclosed.
Abstract translation: 装置,系统和方法涉及使用时变偏压来应用于雪崩光电二极管。 实施例包括确定用于以线性模式应用于雪崩光电二极管的适当时变偏置的系统和方法。 还可以确定具有适当参数的雪崩光电二极管。 公开了附加装置,系统和方法。
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