公开(公告)号：US20210309662A1

公开(公告)日：2021-10-07

申请号：US17122745

申请日：2020-12-15

Applicant: UWM Research Foundation, Inc. ,  Centre for Addiction and Mental Health ,  University of Belgrade - Faculty of Pharmacy

Inventor： James M. Cook ,  Guanguan Li ,  Michael Ming-Jin Poe ,  Miroslav M. Savic ,  Etienne Sibille

IPC: C07D487/04 ,  A61P25/22

Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.

公开(公告)号：US20210284649A1

公开(公告)日：2021-09-16

申请号：US16325080

申请日：2017-08-16

Applicant: UWM Research Foundation, Inc. ,  The Trustees of Columbia University in the City of New York

Inventor： Alexander E. Arnold ,  Douglas C. Stafford ,  James M. Cook ,  Charles W. Emala ,  Gloria Forkuo ,  Rajwana Jahan ,  Revathi Kodali ,  Guanguan Li ,  Michael Rajesh Stephen

IPC: C07D487/14 ,  A61P11/06 ,  C07D487/04

Abstract: Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.

公开(公告)号：US10982286B2

公开(公告)日：2021-04-20

申请号：US15411772

申请日：2017-01-20

Applicant: Mayo Foundation for Medical Education and Research, a charitable corporation of Minnesota ,  The Medical College of Wisconsin, Inc. ,  UWM Research Foundation, Inc.

Inventor： Manish Kohli ,  Liang Wang ,  Chiang-Ching Huang

IPC: C12Q1/6886 ,  A61K31/337 ,  G16H50/20

Abstract: The present invention relates to methods of using cell-free DNA analysis for guiding treatment of advanced prostate cancer. In particular, liquid biopsies are collected from urine and/or plasma of patients for measuring copy number variation in cell-free DNA associated with metastatic prostate cancer. In particular, urine genomic abnormality (UGA) and plasma genomic abnormality (PGA) values are contemplated for use in predicting treatment responses in advanced prostate cancer patients and for use in making decisions related to androgen deprivation therapy (ADT) treatment outcomes in hormone sensitive stage and for starting or changing chemotherapy treatments in castrate resistant advanced cancer stage.

公开(公告)号：US20200316087A1

公开(公告)日：2020-10-08

申请号：US16652914

申请日：2018-10-03

Applicant: UWM Research Foundation, Inc. ,  The Research Foundation for the State University of New York

Inventor： James M. Cook ,  Veera Venkata Naga Phani Babu Tiruveedhula ,  Jun-Xu Li

IPC: A61K31/5517 ,  A61K31/5513 ,  A61P25/22 ,  A61P25/08 ,  A61P23/00

Abstract: Combination therapy with a GABAA agonist and a α1β2/3γ2 GABA inhibitor is for the treatment of pain, epilepsy, or depression with reduced GABAA agonist-mediated adverse effects compared with GABAA agonist therapy alone. Effective doses of α1β2/3γ2 GABA inhibitor reduce GABAA agonist adverse effects without substantial inhibition of therapeutic efficacy.

公开(公告)号：US20200158682A1

公开(公告)日：2020-05-21

申请号：US16631104

申请日：2018-08-10

Applicant: UWM Research Foundation, Inc.

Inventor： Woo-Jin Chang ,  Misong Ryu ,  Mohammad Rizwen Ur Rahman

IPC: G01N27/333 ,  G01N33/18 ,  G01N27/48

Abstract: Composition and electrode for phosphate sensing. In one embodiment, the composition includes a first component, a second component, and a third component. The first component is selected from a group consisting of cobalt oxide nanoparticles, tin (IV) chloride, diphenyl tin dichloride, and ammonium molybdate. The second component includes graphene oxide or reduced graphene oxide. The third component includes pyrrole or polypyrrole.

公开(公告)号：US20200033314A1

公开(公告)日：2020-01-30

申请号：US15767175

申请日：2016-10-14

Applicant: UWM Research Foundation, Inc. ,  AquaMetals, LLC

Inventor： Alan Schwabacher ,  Peter Geissinger ,  Trevor Hagemann ,  Sarah Oehm ,  Tyler G. Fenske ,  Paul Henning ,  Bruce Bathurst

IPC: G01N33/18 ,  C09B29/42 ,  C09B29/036 ,  C09B29/44 ,  G01N21/78 ,  G01N21/64

Abstract: Provided herein are dyes for detecting and distinguishing metals in a sample, as well as compositions and methods comprising the same.

公开(公告)号：US20200001283A1

公开(公告)日：2020-01-02

申请号：US16307400

申请日：2017-06-09

Applicant: UWM Research Foundation, Inc.

Inventor： David Edward John Garman ,  Marcia Renata Quadros Da Silva

IPC: B01J29/06 ,  B01J29/90 ,  B01J37/00 ,  B01J38/02 ,  C02F1/28

Abstract: The present disclosure provides enhanced zeolites and methods of making and using same.

公开(公告)号：US20190300534A1

公开(公告)日：2019-10-03

申请号：US16283926

申请日：2019-02-25

Applicant: UWM Research Foundation, Inc.

Inventor： James M. Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US20190163132A1

公开(公告)日：2019-05-30

申请号：US16092256

申请日：2017-05-04

Applicant: UWM Research Foundation, Inc.

Inventor： Yongjin Sung

IPC: G03H1/04 ,  G03H1/08 ,  G01J3/45

Abstract: This disclosure discloses a method of creating a three-dimensional image of a sample using snapshot optical tomography. The method includes generating a plurality of beams incident on the sample simultaneously, acquiring a field image at a plane not conjugate to the sample plane using off-axis digital holography, extracting amplitude data and phase data for the field image, restoring the sharpness by backpropagating the field image using the extracted amplitude and phase data, acquiring a background image, extracting amplitude data and phase data for the background image, and reconstructing a three-dimensional image of the sample with the backpropagated field image and the background image. The method also includes arranging more than one imaging chains to remove the missing angle artefacts in optical tomography. Also disclosed are systems for performing the method.

公开(公告)号：US10281464B2

公开(公告)日：2019-05-07

申请号：US15500943

申请日：2015-08-03

Applicant: UWM Research Foundation, Inc.

Inventor： Junhong Chen ,  Jingbo Chang

IPC: G01N33/543 ,  G01N27/414 ,  C12Q1/10 ,  C12Q1/689 ,  G01N33/18 ,  G01N33/569

Abstract: Provided herein is a field-effect transistor based sensor for real-time detection of water contaminants and methods of use thereof.