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公开(公告)号:US20220156630A1
公开(公告)日:2022-05-19
申请号:US17435307
申请日:2020-03-03
Applicant: THE UNIVERSITY OF CHICAGO
Inventor: David SCHUSTER , Srivatsan CHAKRAM
IPC: G06N10/70
Abstract: Technologies for resource-efficient quantum error correction are disclosed. A quantum computer may include physical gate qubits, capable of general quantum gate operations such as single-qubit operations and nearest-neighbor two-qubit operations. Each physical qubit gate may be controllably coupled to a quantum memory. The quantum memory may have a lower per-gate error rate than the physical qubit gates as well as a lower per-qubit cost. Because errors accrue at a lower rate in the quantum memory, the physical gate qubits may be able to perform error correction for a large number of logical qubits in the quantum memory, even if the physical gate qubits have an error rate relatively close to an error threshold.
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公开(公告)号:US20220155621A1
公开(公告)日:2022-05-19
申请号:US17435987
申请日:2020-03-04
Applicant: The University of Chicago
Inventor: Kevin C. Miao , Samuel J. Whiteley , David D. Awschalom
IPC: G02F1/03
Abstract: The disclosure is directed to devices, systems, and methods for performing quantum state-mediated microwave-to-optical energy conversion. Such quantum state-mediated energy conversion may be achieved via coherent interactions between an optical excitation and microwave electric field mediated by various quantum states in a defect embedded in a crystalline lattice. Such energy conversion enables coherent electro-optical modulation of optical emission from the defect, microwave-optical transduction, optical detection of microwave, and optical frequency mixing in the optical emission from the defect. The optical emission from the defect maintains and carries quantum coherence in the defect. Such devices and methods may be applied in quantum information processing systems.
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83.
公开(公告)号:US20220131254A1
公开(公告)日:2022-04-28
申请号:US17435565
申请日:2020-03-03
Applicant: THE UNIVERSITY OF CHICAGO
Inventor: DAVID I. SCHUSTER , AZIZA SULEYMANZADE , JONATHAN SIMON , ALEXANDER VLADIMIR ANFEROV
Abstract: A nonlinear parametric device includes a planar substrate and a millimeter-wave resonator formed from superconductive material deposited on the planar substrate. When the resonator is cooled below a critical temperature, it exhibits nonlinear kinetic inductance that may be used to implement millimeter-wave nonlinear frequency generation and parametric amplification. Millimeter waves may be coupled into, and out of, the nonlinear parametric device with hollow rectangular electromagnetic waveguides. Niobium nitride is an excellent superconductive material for kinetic inductance due to its high intrinsic sheet inductance, a critical temperature that is higher than many other superconductive materials, and relatively low loss at millimeter-wave frequencies.
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公开(公告)号:US11247914B2
公开(公告)日:2022-02-15
申请号:US16452949
申请日:2019-06-26
Applicant: The University of Chicago
Inventor: Dmitri V. Talapin , Vishwas Srivastava
Abstract: Methods of synthesizing colloidal ternary Group III-V nanocrystals are provided. Also provided are the colloidal ternary Group III-V nanocrystals made using the methods. In the methods, molten inorganic salts are used as high temperature solvents to carry out cation exchange reactions that convert binary nanocrystals into ternary nanocrystals.
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公开(公告)号:US11246877B2
公开(公告)日:2022-02-15
申请号:US16302185
申请日:2017-05-22
Applicant: The University of Chicago
Inventor: Wenbin Lin , Xiaopin Duan , Christina Chan , Wenbo Han
IPC: A61K31/66 , A61K47/54 , A61P35/00 , A61K9/127 , A61K31/337 , A61K31/357 , A61K31/7048 , A61K31/704 , A61K31/136 , A61K31/7068 , A61K31/4745 , C12N15/11 , A61K31/475 , A61K9/51 , A61K45/06
Abstract: Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.
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86.
公开(公告)号:US11234990B2
公开(公告)日:2022-02-01
申请号:US16596342
申请日:2019-10-08
Applicant: The University of Chicago
Inventor: Deng Pan , Masha Kocherginsky , Suzanne D. Conzen
IPC: A61K31/575 , A61K45/06 , A61K33/243 , A61K31/282 , A61K31/337 , A61K31/357 , A61K31/4745 , A61K31/7068 , A61K39/395 , A61N5/00 , A61J1/00 , A61K31/567 , A61K31/58
Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
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公开(公告)号:US20220001183A1
公开(公告)日:2022-01-06
申请号:US17397192
申请日:2021-08-09
Applicant: Case Western Reserve University , The University of Chicago
Inventor: Dustin James Tyler , Emily Lauren Graczyk , Sliman Julien Bensmaia , Benoit Pierre Delhaye , Hannes Philipp Saal
Abstract: One aspect of the present disclosure relates to a method for controlling levels of perceived intensity of a sensory stimulus. The method includes configuring a stimulation signal with an activation charge rate (ACR) based on a predefined level of intensity by a subject during an action. The ACR is based on a strength of pulses in the stimulation signal parameter and a frequency of pulses in the stimulation signal parameter. The stimulation signal can be applied to neural tissue of a subject during the action. Based on the stimulation signal, the subject can be induced to perceive the predefined level of intensity during the action.
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公开(公告)号:US20210403987A1
公开(公告)日:2021-12-30
申请号:US17466474
申请日:2021-09-03
Inventor: Yamuna Krishnan , Saheli Halder
IPC: C12Q1/6809 , C12N15/113 , C12N15/11 , G01N33/84 , C12Q1/6825 , C12Q1/6816 , C12Q1/00 , C12Q1/02 , C12Q1/6876
Abstract: Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.
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公开(公告)号:US20210386796A1
公开(公告)日:2021-12-16
申请号:US17309185
申请日:2019-11-05
Applicant: The University of Chicago , ClostraBio
Inventor: Cathryn R. NAGLER , Riyue BAO , Dionysios ANTONOPOULOS , John W. COLSON , Lauren Anders HESSER
IPC: A61K35/741 , A23L33/135 , A23L33/21 , A61K45/06 , A61P37/02
Abstract: The current disclosure provides methods and compositions for treating food allergies, infections, autoimmune conditions, and other allergic conditions. Accordingly, the current disclosure relates to a method for treating an infectious, autoimmune, or allergic disease in a subject comprising administering a composition comprising bacterium Anaerostipes caccae to the subject. Further aspects relate to a method for treating a food allergy or for reducing an allergic response to an allergen or for treating or preventing an anaphylactic response in a subject comprising administering a composition comprising bacterium Anaerostipes caccae and a prebiotic to the subject.
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公开(公告)号:US20210361798A1
公开(公告)日:2021-11-25
申请号:US17326860
申请日:2021-05-21
Applicant: The University of Chicago
Inventor: Peter Eng , Patrick J. La Riviere , Jon Brickman , Naoum Issa , Talon Chandler , Michael Proskey , Joanne E. Stubbs
Abstract: A disinfection system includes a mask chamber and a cassette trolley rail mounted to the mask chamber. The system also includes a mask cassette configured to hold one or more masks and configured to mount to the cassette trolley rail such that the mask cassette translates along the cassette trolley rail. The system also includes a first array of lamps mounted to a first lamp mount within the mask chamber, where the first array of lamps is positioned to emit radiation toward a first side of the mask cassette. The system further includes a second array of lamps mounted to a second lamp mount within the mask chamber, where the second array of lamps is positioned to emit radiation toward a second side of the mask cassette that is opposite the first side of the mask cassette.
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