利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

160 条记录 (耗时 0.068 秒)

    METHOD OF SELECTING AN ACTIVE OLIGONUCLEOTIDE PREDICTIVE MODEL
    85.
    发明申请
    METHOD OF SELECTING AN ACTIVE OLIGONUCLEOTIDE PREDICTIVE MODEL 审中-公开
    选择活性寡核苷酸预测模型的方法

    公开(公告)号：US20090082975A1

    公开(公告)日：2009-03-26

    申请号：US12237330

    申请日：2008-09-24

    申请人： Tamara Balac Sipes ,  Susan M. Freier ,  Kenneth Dobie

    发明人： Tamara Balac Sipes ,  Susan M. Freier ,  Kenneth Dobie

    IPC分类号： G01N33/48

    CPC分类号： G16B40/00 ,  G16B25/00

    摘要： The present invention provides a method of identifying a predictor of antisense oligonucleotide activity by identifying properties of oligonucleotides, evaluating oligonucleotide activity of the oligonucleotides, and correlating oligonucleotide activity with the properties. A high correlation between oligonucleotide activity and a property indicates that the property is a predictor of oligonucleotide activity.

    摘要翻译： 本发明提供了通过鉴定寡核苷酸的性质，评价寡核苷酸的寡核苷酸活性以及将寡核苷酸活性与性质相关联来鉴定反义寡核苷酸活性的预测物的方法。 寡核苷酸活性与性质之间的高相关性表明该性质是寡核苷酸活性的预测因子。

    Antisense modulation of insulin-like growth factor binding protein 5 expression
    87.
    发明授权
    Antisense modulation of insulin-like growth factor binding protein 5 expression 有权
    胰岛素样生长因子结合蛋白5表达的反义调制

    公开(公告)号：US06750019B2

    公开(公告)日：2004-06-15

    申请号：US09975123

    申请日：2001-10-09

    申请人： Susan M. Freier

    发明人： Susan M. Freier

    IPC分类号： C12Q168

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor binding protein 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor binding protein 5. Methods of using these compounds for modulation of insulin-like growth factor binding protein 5 expression and for treatment of diseases associated with expression of insulin-like growth factor binding protein 5 are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节胰岛素样生长因子结合蛋白5的表达。组合物包含靶向编码胰岛素样生长因子结合蛋白5的核酸的反义化合物，特别是反义寡核苷酸。使用这些 提供了用于调节胰岛素样生长因子结合蛋白5表达和用于治疗与胰岛素样生长因子结合蛋白5的表达相关的疾病的化合物。

    Antisense modulation of BCAS1 expression
    89.
    发明授权
    Antisense modulation of BCAS1 expression 有权
    BCAS1表达的反义调制

    公开(公告)号：US06395544B1

    公开(公告)日：2002-05-28

    申请号：US09689255

    申请日：2000-10-11

    申请人： Lex M. Cowsert ,  Susan M. Freier

    发明人： Lex M. Cowsert ,  Susan M. Freier

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K48/00 ,  Y02P20/582

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of BCAS1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BCAS1. Methods of using these compounds for modulation of BCAS1 expression and for treatment of diseases associated with expression of BCAS1 are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节BCAS1的表达。 组合物包含靶向编码BCAS1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节BCAS1表达和治疗与BCAS1表达相关疾病的方法。