System and Method for Interacting With a Cell or Tissue in a Body
    83.
    发明申请
    System and Method for Interacting With a Cell or Tissue in a Body 审中-公开
    用于与身体中的细​​胞或组织相互作用的系统和方法

    公开(公告)号:US20080312532A1

    公开(公告)日:2008-12-18

    申请号:US12093720

    申请日:2006-11-14

    IPC分类号: A61B6/00 A61B1/04

    摘要: A system (10, 100, 300, 400) is provided for identifying certain targeted cells or tissues in a body. The system (10, 100, 300, 400) preferably includes at least one ingestible capsule that accommodates or supports (20) at least one of an illuminating module (30, 114, 322, 422, 452), a detecting module (40, 124, 324, 424, 434, 454), an imaging module (50, 326, 432, 456), a control module (60), or a reservoir (70, 132, 312, 412, 442) suitable for retaining and releasing one or more nanoshells. A method (200) is also provided for employing the system (10, 100, 300, 400) to detect, image or otherwise interact with diseased or abnormal cells and/or tissues in a body. The system (10, 100, 300, 400) and method (200) provided allow for improved diagnosing, treating and imaging techniques and for increased sensitivity and specificity in efficiently distinguishing targeted diseased or abnormal cells or tissue from surrounding healthy cells or tissue.

    摘要翻译: 提供系统(10,100,300,400)用于识别身体中的某些靶向细胞或组织。 该系统(10,100,300,400)优选地包括至少一个可摄取的胶囊,其容纳或支撑(20)照明模块(30,114,322,422,452),检测模块(40, 124,324,424,434,454),成像模块(50,326,432,465),控制模块(60)或适于保持和释放的储存器(70,132,312,412,442) 一个或多个纳米壳。 还提供了一种方法(200),其用于使用所述系统(10,100,300,400)来检测,图像或以其他方式与身体中的病变或异常细胞和/或组织相互作用。 提供的系统(10,100,300,400)和方法(200)允许改进的诊断,治疗和成像技术以及用于增强敏感性和特异性,从而有效区分靶向患病或异常细胞或组织与周围健康细胞或组织。

    Optical information medium and a method of manufacturing the medium
    84.
    发明授权
    Optical information medium and a method of manufacturing the medium 有权
    光学信息介质和介质的制造方法

    公开(公告)号:US07172797B2

    公开(公告)日:2007-02-06

    申请号:US10042660

    申请日:2002-01-09

    IPC分类号: B32B3/02

    摘要: An optical information medium (20) for recording, such as DVR-blue, and a method for manufacturing such a medium (20) is provided. Reading from and recording onto the medium (20) is performed by means of a focused radiation beam (10) having a radiation wavelength λ and a numerical aperture NA. Said medium has a substrate (1), and a stack (2) of layers provided thereon. The stack (2) comprises at least a first recording stack (3) and k radiation beam transmissive layers (4, 5). Each transmissive layer (4, 5) has a refractive index ni and an average thickness di μm and 1≦i≦k and k≧2. The thickness dk of layer k (5) is determined by a simple formula which depends on the parameters ni for i=1 . . . k and di for i=1 . . . k−1. Such a medium (20) has zero or substantially zero spherical aberration at the focal point, being at the recording layer of the first recording stack (3), of said radiation beam (10).

    摘要翻译: 提供了用于记录诸如DVR-blue的光学信息介质(20)和用于制造这种介质(20)的方法。 借助于具有辐射波长λ和数值孔径NA的聚焦辐射束(10)进行从介质(20)的读取和记录。 所述介质具有衬底(1)和设置在其上的层叠体(2)。 堆叠(2)至少包括第一记录堆叠(3)和k个辐射束透射层(4,5)。 每个透射层(4,5)具有折射率n i和平均厚度d i m i,并且1≤i≤k且k> = 2。 层k(5)的厚度d k k由一个简单的公式确定,该简单公式取决于i = 1的参数n i i i i i i i。 。 。 k和d i i i i = 1。 。 。 k-1。 这种介质(20)在位于所述辐射束(10)的第一记录叠层(3)的记录层处的焦点处具有零或基本为零的球面像差。

    Scanning device including an objective lens formed of two materials
    85.
    发明授权
    Scanning device including an objective lens formed of two materials 失效
    包括由两种材料形成的物镜的扫描装置

    公开(公告)号:US07149040B2

    公开(公告)日:2006-12-12

    申请号:US10523376

    申请日:2003-07-16

    IPC分类号: G02B3/02 G11B7/135

    摘要: An optical scanning device (1) for scanning an information layer (4) of an optical record carrier (2), the information layer (4) being covered by a transparent layer (3) of thickness td and refractive index nd. The device comprises a radiation source (11) for generating a radiation beam (12, 15, 20) and an objective system (18) for converging the radiation beam on the information layer. The objective system is characterised in comprising a lens comprising a synthetic resin on a substrate, the total thickness t of the lens satisfying the condition: Formula (I), where FWD+td/nd

    摘要翻译: 一种用于扫描光学记录载体(2)的信息层(4)的光学扫描装置(1),所述信息层(4)由厚度为t 1的透明层(3)覆盖, 和折射率n 。 该装置包括用于产生辐射束(12,15,20)的辐射源(11)和用于将辐射束会聚在信息层上的物镜系统(18)。 该目标系统的特征在于包括:在基板上包括合成树脂的透镜,满足以下条件的透镜的总厚度t:公式(I),其中FWD + t ,Phi和FWD以毫米表示。

    Compound objective lens with fold mirror
    86.
    发明授权
    Compound objective lens with fold mirror 失效
    带折叠镜的复合物镜

    公开(公告)号:US07123571B2

    公开(公告)日:2006-10-17

    申请号:US10510255

    申请日:2003-03-20

    IPC分类号: G11B7/00

    CPC分类号: G11B7/1362 G11B7/1374

    摘要: A compound objective lens includes a first lens element and a second lens element, the first element including a mirror surface for internally redirecting a radiation beam passing through the first element. The objective lens has a numerical aperture greater than 0.65, and the focal length F1 of the first element is related to the focal length F of the objective lens by the relation: F 1 F > 2.5 .

    摘要翻译: 复合物镜包括第一透镜元件和第二透镜元件,第一元件包括用于在通过第一元件的辐射束内部重定向的镜面。 物镜具有大于0.65的数值孔径,并且第一元件的焦距F 1 <1>与物镜的焦距F有关,其关系如下: F

      Diffraction device for reading and/or writing a record carrier
      87.
      发明授权
      Diffraction device for reading and/or writing a record carrier 失效
      用于读取和/或写入记录载体的衍射装置

      公开(公告)号:US07079470B2

      公开(公告)日:2006-07-18

      申请号:US10011990

      申请日:2001-12-04

      IPC分类号: G11B7/135

      摘要: A device for reading and/or writing a record carrier (13), the device comprising converging means (35, 45, 47, 106, 108) for focusing a radiation beam (27, 101) originating from a radiation source (25) on the record carrier (13). The converging means comprises polarization means (103) and a diffraction grating (107) of birefringent material. Dependent on the direction of polarization, the radiation beam (101) is focused on one of two possible surfaces corresponding to DVD and DVR, respectively. A diffraction grating (107) is present in a central area of the radiation beam (101) and causes diffraction of a first order for one direction of polarization of the radiation beam (101) and diffraction of a second, higher, order for a second direction of polarization of the radiation beam (101). The diffraction grating (107) is made of birefringent material.

      摘要翻译: 一种用于读取和/或写入记录载体(13)的装置,该装置包括用于将源自辐射源(25)的辐射束(27,101)聚焦在其上的会聚装置(35,45,77,106,108) 记录载体(13)。 会聚装置包括偏振装置(103)和双折射材料的衍射光栅(107)。 取决于偏振方向,辐射束(101)分别聚焦在对应于DVD和DVR的两个可能表面之一上。 衍射光栅(107)存在于辐射束(101)的中心区域中,并且对于辐射束(101)的一个偏振方向引起第一级的衍射,并产生第二级,第二级的衍射 辐射束(101)的偏振方向。 衍射光栅(107)由双折射材料制成。

      Optical scanning device including a tilt tolerant objective system
      88.
      发明授权
      Optical scanning device including a tilt tolerant objective system 失效
      光学扫描装置包括倾斜容限客观系统

      公开(公告)号:US07034974B2

      公开(公告)日:2006-04-25

      申请号:US10518254

      申请日:2003-06-23

      IPC分类号: G02B26/08

      CPC分类号: G11B7/13922 G11B7/1374

      摘要: An optical scanning device (1) for scanning an information layer (4) of an optical record carrier (2), the device including a radiation source (11) for generating a radiation beam (12) and an objective system (18) for converging the radiation beam (12) on the information layer, the objective system (18) being characterized in that the ratio of the root mean square of the optical path difference's (OPD's) generated by the objective system at oblique beam entrance to the system satisfies the condition of formula (I) within the field of the objective system, where OPD(A31) is the contribution of the third order Zernike coma to the root mean square wavefront aberration and OPD(A51) is the contribution of the fifth order Zernike coma to the root mean square wavefront aberration.

      摘要翻译: 一种用于扫描光学记录载体(2)的信息层(4)的光学扫描装置(1),该装置包括用于产生辐射束(12)的辐射源(11)和用于会聚的物镜系统(18) 信息层上的辐射束(12),物镜系统(18)的特征在于,由物镜系统在系统的斜射入口处产生的光程差(OPD)的均方根的比值满足系统 OPD(A31)是第三阶Zernike彗差对均方根波前像差和OPD(A51)的贡献的公式(I)的条件,其中第五阶Zernike昏迷对 均方根波前像差。

      Scanning device including an objective system formed of a single material
      89.
      发明授权
      Scanning device including an objective system formed of a single material 失效
      扫描装置包括由单一材料形成的物镜系统

      公开(公告)号:US07009744B1

      公开(公告)日:2006-03-07

      申请号:US10523388

      申请日:2003-07-16

      IPC分类号: G02B26/08

      CPC分类号: G11B7/1374

      摘要: An optical scanning device (1) for scanning an information layer (4) of an optical record carrier (2), the device (1) comprising a radiation source (11) for generating a radiation beam (12, 15, 20) and an objective system (18) for converging the radiation beam on the information layer, the information layer being covered by a transparent layer (3) of thickness td and refractive index nd. The objective system comprises a lens formed of a single material. The lens satisfies the condition: Fomula (I), where t is the thickness of the lens, FWD is the free working distance between the lens (18) and the carrier (2), where t, td and FWD are expressed in millimeters, and where FWD+td/nd

      摘要翻译: 一种用于扫描光学记录载体(2)的信息层(4)的光学扫描装置(1),所述装置(1)包括用于产生辐射束(12,15,20)的辐射源(11)和 用于将辐射束会聚在信息层上的目标系统(18),该信息层由厚度为td的透明层(3)和折射率n 覆盖。 目标系统包括由单一材料形成的透镜。 透镜满足条件:Fomula(I),其中t是透镜的厚度,FWD是透镜(18)和载体(2)之间的自由工作距离,其中t,td和FWD以毫米表示, 并且其中FWD + t <0.51。

      Optical head for scanning a record carrier
      90.
      发明授权
      Optical head for scanning a record carrier 失效
      用于扫描记录载体的光头

      公开(公告)号:US06956807B2

      公开(公告)日:2005-10-18

      申请号:US09968994

      申请日:2001-10-02

      IPC分类号: G02B5/18 G11B7/00 G11B7/135

      摘要: A device for scanning a first and second type of optical record carriers (2; 40) generates a first and a second radiation beam for scanning the first and second type of record carriers, respectively, the first radiation beam having a first numerical aperture larger than the second numerical aperture of the second radiation beam. The device includes a non-periodic phase structure that does not affect the first radiation beam. The phase structure introduces an amount of spherical aberration in the second radiation beam for scanning the second type of record carriers for compensating the difference in spherical aberration required for scanning through the different thickness of the transparent layer (3; 41) of the first and second type of record carriers (2, 40). To reduce the amount of stray light on the detection system (25) from rays in the second radiation beam having a numerical aperture larger than the second numerical aperture, the phase grating introduces a discontinuity in the gradient of the wavefront deviation it introduces in the second radiation beam. The discontinuity allows spatial filtering in the plane of the detection system (25) of the desired and undesired rays of the second radiation beam.

      摘要翻译: 用于扫描第一和第二类型的光学记录载体(2; 40)的装置分别产生用于扫描第一和第二类型的记录载体的第一和第二辐射束,第一辐射束具有大于 第二辐射束的第二数值孔径。 该装置包括不影响第一辐射束的非周期相位结构。 相位结构在第二辐射束中引入一定量的球面像差,用于扫描第二类型的记录载体,用于补偿扫描通过第一和第二透明层(3; 41)的不同厚度所需的球面像差差 记录载体的类型(2,40)。 为了从具有大于第二数值孔径的数值孔径的第二辐射束中的射线减少检测系统(25)上的杂散光的量,相位光栅在其引入的波前偏差的梯度中引入不连续性 辐射束。 不连续性允许在第二辐射束的期望和不期望的光线的检测系统(25)的平面中进行空间滤波。