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公开(公告)号：US20130078282A1
公开(公告)日：2013-03-28
申请号：US13455585
申请日：2012-04-25
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
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公开(公告)号：US08187637B2
公开(公告)日：2012-05-29
申请号：US11714999
申请日：2007-03-06
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译： 已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂 疾病。 用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。
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公开(公告)号：US20120107241A1
公开(公告)日：2012-05-03
申请号：US13220334
申请日：2011-08-29
申请人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒 药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US20110045079A1
公开(公告)日：2011-02-24
申请号：US12681652
申请日：2008-10-06
申请人： David A. Edwards
发明人： David A. Edwards
CPC分类号： A61K35/74 , A61K9/1617 , A61K9/1623
摘要： Methods and compositions of spray drying cellular material are provided that allow preservation of the cellular material. In one aspect, the cellular material is spray dried with a quantity of excipient. In another aspect, the cellular material is spray dried using a cryoprotectant.
摘要翻译： 提供喷雾干燥多孔材料的方法和组合物，其允许保留细胞材料。 在一个方面，多孔材料用一定量的赋形剂喷雾干燥。 另一方面，细胞材料使用冷冻保护剂进行喷雾干燥。
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公开(公告)号：US07628977B2
公开(公告)日：2009-12-08
申请号：US10420071
申请日：2003-04-18
申请人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David A. Edwards , Robert S. Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
IPC分类号： A61K9/14 , A61K31/66 , A61K31/661 , A61K31/6615
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
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公开(公告)号：US07556798B2
公开(公告)日：2009-07-07
申请号：US09878146
申请日：2001-06-08
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
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公开(公告)号：US20080302082A1
公开(公告)日：2008-12-11
申请号：US12222551
申请日：2008-08-12
申请人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
发明人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
IPC分类号： F02C3/10
摘要： A power transmission arrangement comprises a first power transmission member connectable to a first main shaft of an engine. The arrangement also includes a second power transmission member connectable to a second main shaft of the engine and to a third power transmission member. A coupling assembly is provided which has a selectable coupling condition to couple the first power transmission member to the second power transmission member to allow power to be transmitted from the third power transmission member to the first main shaft of the engine via the first power transmission member. The coupling assembly has a decoupling condition to decouple the first power transmission member from the second power transmission member to allow power to be transmitted from the main shaft of the engine to the third power transmission member via the second power transmission member.
摘要翻译： 动力传递装置包括可连接到发动机的第一主轴的第一动力传递构件。 该装置还包括可连接到发动机的第二主轴和第三动力传递构件的第二动力传递构件。 提供了一种联接组件，其具有可选择的联接状态，以将第一动力传递构件联接到第二动力传递构件，以允许动力经由第一动力传递构件从第三动力传递构件传递到发动机的第一主轴 。 联接组件具有去耦条件，以将第一动力传递构件与第二动力传递构件分离，以允许动力经由第二动力传递构件从发动机的主轴传递到第三动力传递构件。
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公开(公告)号：US07451066B2
公开(公告)日：2008-11-11
申请号：US10900176
申请日：2004-07-27
CPC分类号： E21B49/00
摘要： A “near wellbore modeling” software will, when executed by a processor of a computer, model a localized area of a reservoir field which surrounds and is located near a specific wellbore in the reservoir field by performing the following functions: (1) receive input data representative of a reservoir field containing a plurality of wellbores, (2) establish a boundary around one specific wellbore in the reservoir field which will be individually modeled and simulated, (3) impose an “fine scale” unstructured grid inside the boundary consisting of a plurality of tetrahedrally shaped grid cells and further impose a fine scale structured grid about the perforated sections of the specific wellbore, (4) determine a plurality of fluxes/pressure values at the boundary, the fluxes/pressure values representing characteristics of the reservoir field located outside the boundary, (5) establish one or more properties for each tetrahedral cell of the unstructured grid and each cylindrical grid cell of the structured grid, (6) run a simulation, using the fluxes/pressure values at the boundary to mimic the reservoir field outside the boundary and using the fine scale grid inside the boundary, to thereby determine a plurality of simulation results corresponding, respectively, to the plurality of grid cells located inside the boundary, the plurality of simulation results being representative of a set of characteristics of the reservoir field located inside the boundary, (7) display the plurality of simulation results which characterize the reservoir field located inside the boundary, and (8) reintegrate by coarsening the grid inside the boundary, imposing a structured grid outside the boundary, and re-running a simulation of the entire reservoir field.
摘要翻译： 当“计算机”的处理器执行时，“近井眼建模”软件将通过执行以下功能来模拟围绕并位于储层区域中的特定井眼附近的储层场的局部区域：（1）接收输入 表示包含多个井筒的储层场的数据，（2）在储层场内围绕一个特定的井眼建立边界，该边界将被单独建模和模拟，（3）在由边界组成的边界内施加“微细尺度”非结构网格 多个四面体形状的网格单元，并进一步在特定井筒的穿孔部分周围施加细微尺度的结构网格，（4）确定边界处的多个通量/压力值，表示储层场的特征的通量/压力值 位于边界之外，（5）为非结构化网格的每个四面体单元建立一个或多个属性，并且每个圆柱形网格单元 结构化网格，（6）运行模拟，使用边界处的通量/压力值模拟边界外的储层场，并使用边界内的精细尺度网格，从而确定分别对应的多个模拟结果， 对于位于边界内的多个网格单元，多个模拟结果代表位于边界内的储层场的一组特征，（7）显示表征位于边界内的储层场的多个模拟结果 ，（8）通过在边界内粗化网格来重新整合，在边界外部施加结构化网格，并重新运行整个油藏场的模拟。
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公开(公告)号：US07435408B2
公开(公告)日：2008-10-14
申请号：US10818902
申请日：2004-04-06
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K38/00 , A61K33/00 , A61K31/00 , A61K31/70 , A61K31/7052
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译： 提供用于向肺系统递送药物的改进的多孔颗粒，以及用于其合成和给药的方法。 在优选的实施方案中，多孔颗粒由可生物降解的材料制成，并具有小于0.4g / cm 3的质量密度。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如，颗粒可以由官能化的聚酯接枝共聚物形成，该聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的至少一个（氨基酸）侧链 集团在聚酯骨干。 在一个实施方案中，具有相对大的平均直径，例如大于5um的多孔颗粒可用于增强治疗剂递送至肺的肺泡区域。 掺入治疗剂的多孔颗粒可以有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。
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公开(公告)号：US07384649B2
公开(公告)日：2008-06-10
申请号：US11633750
申请日：2006-12-05
IPC分类号： A61K9/50
CPC分类号： A61K9/0075 , A61K9/1694
摘要： This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (σ) is greater than 2, optimally greater than 3.
摘要翻译： 本发明涉及用于将药物递送至肺部系统的改进的颗粒组合物。 申请人公开了一种识别高分散性的空气动力学轻微颗粒的最佳形式的方法。 本发明的颗粒通过在颗粒形成过程中产生塌陷的中空的球形药物颗粒（即祖细胞颗粒）制成，导致具有非常低的包膜密度的褶皱，薄壁的药物颗粒。 此外，申请人已经发现，当表面积参数（σ）大于2，最佳大于3时，这些颗粒对于吸入的气溶胶是特别优选的。
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