摘要:
A process for producing a ferric aminopolycarboxylic acid chelate with improved long term stability is disclosed. The process involves heating a mixture of iron oxide, ammonia and aminopolycarboxylic acid chelant at an elevated temperature for a sufficient time to improve the stability of the formed chelate.
摘要:
A method for the preparation of concentrated, stable iron chelate solutions of alkali metal polyamino succinic acids is disclosed. The method involves the co-feeding of an alkaline alkali-metal succinate solution and a ferric salt solution into a vessel.
摘要:
A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylethyl iminodiacetic acid via hydrolysis.
摘要:
A method for the preparation of concentrated, stable iron chelate solutions of alkali metal polyamino disuccinic acids is disclosed. The method involves the controlled addition of the alkaline alkali-metal succinate solution to an agitated aqueous ferric salt solution.
摘要:
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要:
Polyamino monosuccinic acid chelants are disclosed which have been found to be applicable in photographic processes. The polyamino monosuccinic acids can be used in a method of bleaching or bleach-fixing a silver halide photographic material comprising contacting the photographic material with a bleaching solution containing a metal complex of a polyamino monosuccinic acid as a bleaching agent.
摘要:
Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.
摘要:
The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from the group consisting of Samarium-153, Gadolinium-159, and Holmium-166 and 1,4,7,10-tetraazacyclododecanetetramethylenephosphonic acid a physiologically acceptable salt thereof. Suitable compositions for use in this method are also provided.
摘要:
A process for inhibiting the deposition of manganese in water systems by adding to the water a sufficient amount of an organic aminophosphonic acid to inhibit corrosion and scale resulting from undesirable manganese deposition.