Radioactive compositions for the treatment of calcific tumors
    88.
    发明授权
    Radioactive compositions for the treatment of calcific tumors 失效
    用于治疗钙化肿瘤的放射性组合物

    公开(公告)号:US4897254A

    公开(公告)日:1990-01-30

    申请号:US21382

    申请日:1987-03-03

    IPC分类号: A61K51/04

    CPC分类号: A61K51/0478 A61K2121/00

    摘要: Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.

    摘要翻译: 某些发射粒子的放射性核素,例如 钐-153已经与某些亚烷基聚氨基羧酸螯合剂络合。 已经发现含有这些复合物的组合物可用于治疗动物中的钙化肿瘤。 有用复合物的稳定常数log K为约14至约17,组合物中螯合剂与放射性核素的摩尔比使得螯合剂以足以抑制软组织吸收放射性核素的量存在。