公开(公告)号：US20230089738A1

公开(公告)日：2023-03-23

申请号：US17992730

申请日：2022-11-22

Applicant: Edwards Lifesciences Corporation

Inventor： Adi Carmi ,  Boaz Manash ,  Nikolai Gurovich ,  Michael Bukin

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a prosthetic valve and an anchoring frame. The prosthetic valve includes a valve frame and a valve structure. The valve frame includes a plurality of struts and is expandable from a compressed configuration to an expanded configuration. The valvular structure includes leaflets. The valvular structure is disposed radially within and is coupled to the valve frame. The valvular structure is configured to allow blood flow through the prosthetic valve assembly in a first direction and to restrict blood flow through the prosthetic valve assembly in a second direction. The anchoring frame includes a plurality of struts. The anchoring frame is disposed radially outwardly from and is coupled to the valve frame. The struts of the anchoring frame comprise one or more tissue-engaging elements configured for contacting native tissue to help secure the prosthetic valve assembly at an implantation location.

公开(公告)号：US20230065795A1

公开(公告)日：2023-03-02

申请号：US18054305

申请日：2022-11-10

Applicant: Edwards Lifesciences Corporation

Inventor： Shahram Zamani ,  Tyler Dale O'Dell ,  Tamir S. Levi ,  Michael Bukin ,  Noam Nir ,  Ziv Yohanan

IPC: A61F2/24

Abstract: A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including an annular frame and a plurality of leaflets is disclosed. As one example, the valve includes a plurality of commissures, each commissure including an attachment member including a protruding portion, a first commissure tab of a first leaflet of the plurality of leaflets arranged adjacent to a first side of the protruding portion and secured directly to the attachment member. Each commissure further includes a second commissure tab of a second leaflet of the plurality of leaflets arranged adjacent to an opposite, second side of the protruding portion and secured directly to the attachment member.

公开(公告)号：US20220323209A1

公开(公告)日：2022-10-13

申请号：US17851232

申请日：2022-06-28

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin ,  Elena Sherman

IPC: A61F2/24 ,  B29C65/62

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming each of a plurality of commissures with a plurality of leaflets by pairing a first commissure tab of a first leaflet with an adjacent, second commissure tab of a second leaflet, folding a support strip over an inner reinforcing element, positioning the folded support strip between the first and second commissure tabs, and attaching first and second outer reinforcing elements to the first and second commissure tabs, respectively, via stitching, the stitching extending over at least a portion of the first reinforcing element opposite a fold region of the support strip, and, for each commissure, securing end portions of the support strip to a respective support portion of a frame of the prosthetic heart valve.

公开(公告)号：US20220287834A1

公开(公告)日：2022-09-15

申请号：US17827377

申请日：2022-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： Tal Reich ,  Noam Nir ,  Ziv Yohanan ,  Tamir S. Levi ,  Michael Bukin

IPC: A61F2/24

Abstract: A belt for an implantable prosthetic device can include an annular body including a plurality of alternating peaks and valleys and a plurality of frangible members extending between at least one of adjacent peaks and adjacent valleys. The annular body can be radially expandable from a radially compressed configuration to a first diameter upon application of a radially outwardly directed force via an expandable implantable prosthetic device. A first frangible member of the plurality of frangible members can be configured to break when the radially outwardly directed force exceeds a first predetermined threshold to allow radial expansion of the annular body to a second diameter.

公开(公告)号：US20220241071A1

公开(公告)日：2022-08-04

申请号：US17659577

申请日：2022-04-18

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.

公开(公告)号：US20220241070A1

公开(公告)日：2022-08-04

申请号：US17659169

申请日：2022-04-13

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24

Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.

公开(公告)号：US20220192831A1

公开(公告)日：2022-06-23

申请号：US17654570

申请日：2022-03-11

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Boaz Manash ,  Eason Michael Abbott ,  John J. Desrosiers ,  Christine Marie Heyninck-Jantz

IPC: A61F2/24 ,  A61F2/00

Abstract: Devices, systems and methods for situating a device within a variety vasculature morphologies are provided. An expandable device can adapt to the local vasculature morphology and still provide a controlled inner diameter is described. A device for situating within the inferior vena cava and superior vena cava is described. Systems and methods for utilizing devices are described.

公开(公告)号：US20210369452A1

公开(公告)日：2021-12-02

申请号：US17399966

申请日：2021-08-11

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Elena Sherman ,  Michael Bukin ,  Tomer Saar

IPC: A61F2/24

Abstract: An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. The sutures are inward of the outermost surface of an outer periphery of the frame assembly. In certain embodiments the struts contain recesses in which sutures can be disposed. In other embodiments, the struts can have holes through them which the sutures pass through. The implantable prosthetic valve assembly can also be collapsed within a catheter such that an outermost surface of a periphery of the frame assembly touches the catheter but the sutures are spaced apart from the catheter or are flush with the outer surface of the frame.

公开(公告)号：US20210322163A1

公开(公告)日：2021-10-21

申请号：US17363241

申请日：2021-06-30

Applicant: Edwards Lifesciences Corporation

Inventor： Diana Nguyen-Thien-Nhon ,  Timothy A. Geiser ,  Larry L. Wood ,  Dinesh L. Sirimanne ,  Son V. Nguyen ,  Tamir S. Levi ,  Nikolay Gurovich ,  Michael Bukin

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a frame, a valvular structure, and a skirt. The frame is movable between collapsed and expanded configurations and includes struts disposed between inflow and outflow ends, apices disposed at the inflow end formed by intersections of two or more struts, and junctions disposed between the apices and the outflow end and formed by intersections of two or more struts. The apices are circumferentially offset from the junctions. The valvular structure is positioned within and secured to the frame. The skirt is secured to the frame and includes a first edge portion and a second edge portion. The first edge portion is secured to the frame at the apices. The second edge portion is secured to the frame at the junctions. The skirt is configured to retract inwardly between the apices when the frame is moved from the radially expanded configuration to the radially collapsed configuration.

公开(公告)号：US20210259833A1

公开(公告)日：2021-08-26

申请号：US17320004

申请日：2021-05-13

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir ,  Ziv Yohanan ,  Amir Keret ,  Elena Sherman

IPC: A61F2/24

Abstract: A prosthetic heart valve includes an annular frame including a plurality of angled strut members that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The frame has an inflow end and an outflow end, and includes a leaflet structure positioned within the frame, the leaflet structure comprising a plurality of leaflets arranged to form a plurality of commissures. The frame includes a plurality of commissure support elements, each commissure support element being positioned at one of the commissures. Each of the commissure support elements has a coupling portion coupled to the frame and first and second members coupled to the coupling portion and extending in a direction toward the inflow end of the frame or toward the outflow end of the frame. The leaflets of each commissure are received between the first and second members of the respective commissure support element.