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公开(公告)号：US20220160507A1
公开(公告)日：2022-05-26
申请号：US17670290
申请日：2022-02-11
IPC分类号： A61F2/24
摘要： A prosthetic heart valve and delivery device for delivering the prosthetic heart valve to a target implantation site, which reduce contact between the prosthetic heart valve and a delivery sheath through which the delivery device is advanced to the target implantation site, is disclosed. As one example, a prosthetic heart valve may comprise a frame including a first end with a plurality of apices spaced apart from one another around a circumference of the first end and a cover element covering the plurality of apices. The cover element may include a cushioning element or a bio-resorbable element.
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公开(公告)号：US20220241071A1
公开(公告)日：2022-08-04
申请号：US17659577
申请日：2022-04-18
发明人： Nikolay Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
IPC分类号： A61F2/24
摘要： A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.
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公开(公告)号：US20220241070A1
公开(公告)日：2022-08-04
申请号：US17659169
申请日：2022-04-13
发明人： Nikolay Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
IPC分类号： A61F2/24
摘要： A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.
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公开(公告)号：US12029644B2
公开(公告)日：2024-07-09
申请号：US16937964
申请日：2020-07-24
发明人： Nikolai Gurovich , Alexey Tsypenyuk
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2230/001 , A61F2230/006 , A61F2250/0039
摘要： A prosthetic heart valve includes a frame having an inflow end, an outflow end, and a central portion. The frame is radially expandable from a collapsed configuration to an expanded configuration. The inflow end includes a plurality of first strut members having a first strut width and forming a first angle between adjacent first strut members, and the central portion includes a plurality of second strut members having a second strut width and forming a second angle between adjacent second strut members. A plurality of leaflets are positioned within the frame. At least one of the first angle and the second angle, or the first strut width and the second strut width, are different such that when the prosthetic heart valve is crimped onto a cylindrical balloon and expanded using the cylindrical balloon, a diameter of the outflow end is different from a diameter of the central portion.
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公开(公告)号：US11872125B2
公开(公告)日：2024-01-16
申请号：US17659577
申请日：2022-04-18
发明人： Nikolai Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2412 , A61F2/90 , A61F2220/0075 , A61F2230/0023 , A61F2230/0052 , A61F2250/0003 , A61F2250/0039 , A61F2250/0069 , A61F2310/00017 , A61F2310/00029 , A61F2310/00059
摘要： A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.
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公开(公告)号：US20230277313A1
公开(公告)日：2023-09-07
申请号：US18316942
申请日：2023-05-12
发明人： Nikolai Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/2409 , A61F2250/0069 , A61F2250/0003 , A61F2230/0052 , A61F2230/0023 , A61F2/2412 , A61F2/90
摘要： A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end, an outflow end, and a plurality of struts. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a coaptation edge portion and a cusp edge portion. The cusp edge portion of each leaflet can be folded toward the outflow end of the frame along a bending axis and a reinforcing member extends along an outflow surface of the cusp edge portion along the bending axis. The prosthetic heart valve can include a plurality of connecting skirts, each disposed between the cusp edge portion of an adjacent leaflet and the frame. First stitching secures the reinforcing member and the connecting skirts to the cusp edge portions and second stitching secures the connecting skirts to selected struts of the frame.
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公开(公告)号：US20240358503A1
公开(公告)日：2024-10-31
申请号：US18767437
申请日：2024-07-09
发明人： Nikolai Gurovich , Michael Bukin , Alexey Tsypenyuk , Elena Sherman , Dikla Kersh , Boaz Manash , Liron Tayeb , Ziv Yohanan , Alexander Barash , Yair A. Neumann , Tomer Saar
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0033 , A61F2220/0075 , A61F2220/0091 , A61F2230/0069
摘要： A prosthetic heart valve includes an annular frame including a plurality of strut members, the frame being radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. A leaflet structure is situated at least partially within the frame, the leaflet structure including a plurality of leaflets, each leaflet having opposing commissure tab portions on opposite sides of the leaflet, each commissure tab portion being paired with an adjacent commissure tab portion of an adjacent leaflet to form a commissure, the commissure tab portions of each leaflet being folded such that each commissure tab portion forms a plurality of layers. A reinforcement member of a plurality of reinforcement members is positioned between the layers of each commissure tab portion. Each commissure tab portion of each leaflet is positioned entirely within the frame.
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公开(公告)号：US11806234B2
公开(公告)日：2023-11-07
申请号：US17659169
申请日：2022-04-13
发明人： Nikolai Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2412 , A61F2/90 , A61F2220/0075 , A61F2230/0023 , A61F2230/0052 , A61F2250/0003 , A61F2250/0039 , A61F2250/0069 , A61F2310/00017 , A61F2310/00029 , A61F2310/00059
摘要： A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.
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公开(公告)号：US20210259832A1
公开(公告)日：2021-08-26
申请号：US17316885
申请日：2021-05-11
发明人： Nikolay Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
IPC分类号： A61F2/24
摘要： A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end portion and an outflow end portion, the frame comprising a plurality of struts defining openings between them. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a main body, opposing tabs on opposite sides of the main body, a coaptation edge portion, and a cusp edge portion. Each tab can be paired with an adjacent tab of an adjacent leaflet to form a plurality of commissures that are fixed relative to the frame, and each leaflet can have opposing edge portions between the opposing tabs and the cusp edge portion that are unattached to the frame, each unattached edge portion defining a gap that extends radially into the main body of the leaflet.
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公开(公告)号：US20240325143A1
公开(公告)日：2024-10-03
申请号：US18737015
申请日：2024-06-07
发明人： Nikolai Gurovich , Alexey Tsypenyuk
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2230/001 , A61F2230/006 , A61F2250/0039
摘要： A prosthetic heart valve includes a frame made of a plastically expandable material and including an inflow end, an outflow end, and a central portion between the inflow end and the outflow end. The frame is radially collapsible and expandable. The inflow end includes a plurality of circumferentially extending first strut members having a first strut width and forming a first angle between adjacent first strut members, and the central portion includes a plurality of circumferentially extending second strut members having a second strut width and forming a second angle between adjacent second strut members. A plurality of leaflets is positioned within the frame and configured to regulate blood flow through the prosthetic heart valve. The first strut width of the first strut members at the inflow end of the frame is greater than the second strut width of the second strut members in the central portion of the frame.
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