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公开(公告)号:US20090047296A1
公开(公告)日:2009-02-19
申请号:US11833954
申请日:2007-08-03
申请人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译: 制备包括MeVal-Val-Dil-Dap-Norephedrine(MMAE)和MeVal-Val-Dil-Dap-Phe(MMAF)的Auristatin肽,并通过各种接头包括马来酰亚胺酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号:US20080248053A1
公开(公告)日:2008-10-09
申请号:US11833959
申请日:2007-08-03
申请人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译: 制备包括MeVal-Val-Dil-Dap-Norephedrine(MMAE)和MeVal-Val-Dil-Dap-Phe(MMAF)的Auristatin肽,并通过各种接头包括马来酰亚胺酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号:US20080124739A1
公开(公告)日:2008-05-29
申请号:US11943454
申请日:2007-11-20
申请人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
发明人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan D. Spencer , Thomas D. Wu , Zemin Zhang
CPC分类号: C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20080124331A1
公开(公告)日:2008-05-29
申请号:US11733861
申请日:2007-04-11
申请人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang , Mark Sliwkowski
发明人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang , Mark Sliwkowski
IPC分类号: A61K31/70 , A61K39/395 , A61P43/00 , C07H21/04 , C07K16/18 , C12N5/06 , G01N33/574
CPC分类号: G01N33/57484 , A61K47/60 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6839 , A61K47/6851 , A61K47/6859 , A61K51/1006 , A61K51/1018 , A61K2039/505 , C07K16/1072 , C07K16/18 , C07K16/30 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/77
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20070243193A1
公开(公告)日:2007-10-18
申请号:US11627272
申请日:2007-01-25
申请人: Gretchen Frantz , Paul Polakis , Susan Spencer , Thomas Wu , Zemin Zhang
发明人: Gretchen Frantz , Paul Polakis , Susan Spencer , Thomas Wu , Zemin Zhang
IPC分类号: A61K39/00 , C12Q1/68 , G01N33/574
CPC分类号: C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K16/2803 , C12N2799/026
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物,以及使用这些物质组合物的方法。
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公开(公告)号:US20070048825A1
公开(公告)日:2007-03-01
申请号:US11538517
申请日:2006-10-04
申请人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
CPC分类号: C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20070048218A1
公开(公告)日:2007-03-01
申请号:US11538566
申请日:2006-10-04
申请人: Gretchen Frantz , Kenneth Hillan , Heidi Phillips , Paul Polakis , Susan Spencer , P. Williams , Thomas Wu , Zemin Zhang
发明人: Gretchen Frantz , Kenneth Hillan , Heidi Phillips , Paul Polakis , Susan Spencer , P. Williams , Thomas Wu , Zemin Zhang
IPC分类号: A61K51/00 , A61K39/395 , C07K16/46 , C07K16/30
CPC分类号: C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20070031901A1
公开(公告)日:2007-02-08
申请号:US11457750
申请日:2006-07-14
申请人: Avi Ashkenazi , Audrey Goddard , Paul Godowski , Austin Gurney , Paul Polakis , P. Williams , William Wood , Thomas Wu , Zemin Zhang
发明人: Avi Ashkenazi , Audrey Goddard , Paul Godowski , Austin Gurney , Paul Polakis , P. Williams , William Wood , Thomas Wu , Zemin Zhang
IPC分类号: G01N33/574 , C07K16/30
CPC分类号: C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/574
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20060147374A1
公开(公告)日:2006-07-06
申请号:US11335394
申请日:2006-01-18
申请人: Gretchen Frantz , Kenneth Hillan , Paul Polakis , Beni Wolf , Thomas Wu , Zemin Zhang
发明人: Gretchen Frantz , Kenneth Hillan , Paul Polakis , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号: A61K51/00 , A61K39/395
CPC分类号: C07K16/30
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20060147373A1
公开(公告)日:2006-07-06
申请号:US11226554
申请日:2005-09-13
申请人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang
发明人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang
IPC分类号: A61K51/00 , A61K39/395 , C07K16/46
CPC分类号: C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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