公开(公告)号：US20130182690A1

公开(公告)日：2013-07-18

申请号：US13808768

申请日：2010-07-08

申请人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

发明人： Istvan Zsolt Kovacs ,  Frank Frederiksen ,  Luis Garcia

IPC分类号： H04W72/04

CPC分类号： H04W72/0426 ,  H04W16/06 ,  H04W72/082

摘要： The invention relates generally to mobile communication networks. More particularly, the invention relates to interference management and carrier selection for transmitting data. There is provided a solution for improved selection of a cell-specific base carrier, the solution utilizing a timing framework for the carrier selection. The solution includes determining a maximum allowed time duration, and performing within the determined maximum allowed time duration: obtaining information related to one or more selected carriers from at least one neighboring base station, selecting the at least one cell-specific base carrier for data transmission on the basis of the obtained information, and informing the at least one neighboring base station of the selected cell specific base carrier.

摘要翻译： 本发明一般涉及移动通信网络。 更具体地，本发明涉及用于发送数据的干扰管理和载波选择。 提供了一种用于改进小区特定基站载波选择的解决方案，该解决方案利用用于载波选择的定时框架。 该解决方案包括确定最大允许持续时间，以及在所确定的最大允许持续时间内执行：从至少一个相邻基站获得与一个或多个选定载波相关的信息，选择所述至少一个小区特定基站载波进行数据传输 基于所获得的信息，并且向所述至少一个相邻基站通知所选择的小区特定基站载波。

公开(公告)号：US20130072541A1

公开(公告)日：2013-03-21

申请号：US13458037

申请日：2012-04-27

申请人： Luis Garcia

发明人： Luis Garcia

IPC分类号： C12N5/10 ,  A61P21/00 ,  A61K31/713

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2750/14143

摘要： The invention concerns an adeno-associated viral vector comprising: a U7 type modified snRNA sequence; the native U7 promoter; at least one antisense sequence directed against at least one splice site of at least one exon, the said exon encoding a dispensable domain of dystrophin.

摘要翻译： 本发明涉及腺相关病毒载体，其包含：U7型修饰的snRNA序列; 天然U7启动子; 至少一个针对至少一个外显子的至少一个剪接位点的反义序列，所述外显子编码肌营养不良蛋白的可分配区域。

公开(公告)号：US20130045538A1

公开(公告)日：2013-02-21

申请号：US13635356

申请日：2011-03-17

申请人： Luis Garcia ,  Denis Furling ,  Cyriaque Beley ,  Thomas Voit

发明人： Luis Garcia ,  Denis Furling ,  Cyriaque Beley ,  Thomas Voit

IPC分类号： C07H21/02 ,  C12N15/113 ,  C12N15/85 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/531 ,  C12N2320/33 ,  C12N2320/34 ,  C12N2320/50 ,  C12N2330/51

摘要： The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.

摘要翻译： 本发明涉及一种改善在基于RNA的疗法的上下文中使用的工程化U7 snRNA的活性的方法; 特别是在外显子跳跃，外显子包含和mRNA消除策略。 所产生的修饰的snRNA可用于治疗神经肌肉疾病，特别是Duchenne神经肌肉营养不良症，强直性营养不良DM1和脊髓性肌肉萎缩。

公开(公告)号：US08376489B2

公开(公告)日：2013-02-19

申请号：US13077438

申请日：2011-03-31

申请人： Sergio Puigardeu ,  Luis Garcia ,  M. Isabel Borrell ,  Ángel Martinez

发明人： Sergio Puigardeu ,  Luis Garcia ,  M. Isabel Borrell ,  Ángel Martinez

IPC分类号： B41J29/38

CPC分类号： B41J2/16579

摘要： In one embodiment, first printing is caused in response to a print job, applying ink upon a media utilizing a first row of printheads and a second row of printheads. The first row of printheads includes a plurality of printhead types. The second row of printheads is adjacent to the first row and includes at least one printhead of each of types. Failure of a first printhead within the first row is detected. The status of printheads included within the second row is analyzed. Second printing is caused applying ink upon the media utilizing the second row of printheads, and not the first row of printheads, in response to determining that printheads within the second row are operable to complete the print job.

摘要翻译： 在一个实施例中，响应于打印作业而引起第一次打印，使用第一排打印头和第二排打印头将墨施加到介质上。 第一排打印头包括多个打印头类型。 第二排打印头与第一排相邻并且包括每种类型的至少一个打印头。 检测到第一行内的第一打印头的故障。 分析第二行内打印头的状态。 响应于确定第二行中的打印头可操作以完成打印作业，使得利用第二排打印头而不是第一排打印头在介质上施加墨水。

公开(公告)号：US20120282960A1

公开(公告)日：2012-11-08

申请号：US13518476

申请日：2009-12-23

申请人： Klaus Ingemann Pedersen ,  Luis Garcia

发明人： Klaus Ingemann Pedersen ,  Luis Garcia

IPC分类号： H04W52/24

CPC分类号： H04W52/243

摘要： When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.

摘要翻译： 当确定从与其他接入节点相关联的传输到与第一接入节点相关联的传输的总干扰水平的第一估计超过预定目标最大值时; 然后根据所述第一估计超过所述目标最大值的程度，选择一个或多个所述其他接入节点，以向其请求以降低干扰传输的传输功率，和/或选择一个 请求任何一个或多个所述其他接入节点以降低干扰传输的传输功率。

公开(公告)号：US20120252437A1

公开(公告)日：2012-10-04

申请号：US13065742

申请日：2011-03-28

申请人： Luis Garcia ,  Frank Frederiksen ,  Klaus Ingemann Pedersen

发明人： Luis Garcia ,  Frank Frederiksen ,  Klaus Ingemann Pedersen

IPC分类号： H04W24/00

CPC分类号： H04J11/0056

摘要： Wireless channel interference information is determined (e.g., a background interference matrix BIM constructed from multiple user equipment measurements). Reliability of the interference information is classified and sent with the interference information to a neighbor network access node such as a HeNB. In various embodiments there are three layers of reliability, the above being the first. The second layer utilizes variability of a plurality of such reliability indications received from the same neighbor HeNB, which is updated as new interference information and reliability indications are received from that same neighbor HeNB. The third layer utilizes a peer review/update process on the neighbor HeNBs themselves, where each HeNB's performance is shared among all and updated by one another as different HeNBs utilize one another's BIM and assesses how reliably it reflected actual interference conditions. This addresses concerns for data/source reliability since communication interfaces among HeNB groups may not be controlled by a single network operator.

摘要翻译： 确定无线信道干扰信息（例如，由多个用户设备测量构成的背景干扰矩阵BIM）。 干扰信息的可靠性被分类并与干扰信息一起发送到诸如HeNB的邻居网络接入节点。 在各种实施例中，存在三层可靠性，上述是第一层。 第二层利用从相同的邻近HeNB接收的多个这样的可靠性指示的可变性，其被更新为新的干扰信息，并且从相同的邻居HeNB接收可靠性指示。 第三层利用对邻居HeNB本身的对等审查/更新过程，其中每个HeNB的性能由所有HeNB彼此共享并且彼此更新，因为HeNB不同的BNB利用彼此的BIM并且评估它们如何可靠地反映实际的干扰条件。 这解决了数据/源可靠性的问题，因为HeNB组之间的通信接口可能不由单个网络运营商控制。

公开(公告)号：US20120245220A1

公开(公告)日：2012-09-27

申请号：US13500612

申请日：2010-10-08

申请人： Luis Garcia ,  Stéphanie Lorain

发明人： Luis Garcia ,  Stéphanie Lorain

IPC分类号： C07H21/00 ,  A61K48/00 ,  A61K31/7088 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K14/4708 ,  A61K48/005 ,  C12N15/85 ,  C12N2840/445 ,  C12N2840/85

摘要： The present invention provided methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (Chimeric RNA).

摘要翻译： 本发明提供了通过靶向剪接体介导的简单或双转录产生新型核酸分子的方法和组合物。 本发明的组合物包括被设计为与靶前体信使RNA分子（靶前mRNA）相互作用并且介导简单或双重反式剪接反应的预转录分子（PTM），导致产生新的嵌合 RNA分子（嵌合RNA）。

公开(公告)号：US20120149756A1

公开(公告)日：2012-06-14

申请号：US13263949

申请日：2010-04-09

申请人： Daniel Schümperli ,  Christian Leumann ,  Denis Furling ,  Luis Garcia ,  Thomas Voit

发明人： Daniel Schümperli ,  Christian Leumann ,  Denis Furling ,  Luis Garcia ,  Thomas Voit

IPC分类号： A61K31/712 ,  A61P21/00 ,  A61P25/00 ,  C07H21/04 ,  C12N5/071

CPC分类号： C12N15/113 ,  A61K31/711 ,  A61K31/712 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/3231 ,  C12N2320/33

摘要： Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stem-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMN1 protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DM1 mRNA comprising 3′-terminal CUG repeats.

摘要翻译： 提供三环DNA（tc-DNA）AON和使用tc-DNA AON来改变在mRNA前处理期间发生的剪接事件的方法。 描述了Tricyclo-DNA（tc-DNA）AON，其可用于促进外显子跳跃或在mRNA前处理期间掩盖内含子沉默子序列和/或末端茎环序列，并靶向核糖核酸酶介导的加工mRNA的破坏。 本文所述的Tc-DNA AON可用于通过跳过肌营养不良蛋白基因内突变外显子23或外显子51来恢复肌营养不良蛋白功能的方法来治疗杜氏肌营养不良症; 在通过掩蔽SMN2基因内的内含子沉默序列和/或末端茎环序列来治疗脊髓性肌萎缩的方法中，以产生修饰的功能性SMN2蛋白，包括由外显子7编码的氨基酸序列，其能够在 最少部分补充非功能性SMN1蛋白; 以及用于通过靶向包含3'-末端CUG重复序列的突变的DM1mRNA的破坏来治疗Steinert's强直性营养不良的方法。

公开(公告)号：US20110292436A1

公开(公告)日：2011-12-01

申请号：US12789752

申请日：2010-05-28

申请人： Sergio PUIGARDEU ,  Luis Garcia ,  Marc Serra ,  Fco. Javier Roses ,  Angel Martinez

发明人： Sergio PUIGARDEU ,  Luis Garcia ,  Marc Serra ,  Fco. Javier Roses ,  Angel Martinez

IPC分类号： G06F3/12

CPC分类号： G06F3/1284 ,  G06F3/1208 ,  G06F3/1244 ,  G06F3/1254

摘要： A method and a print apparatus are described. The method and the print apparatus allow for selecting from a plurality of print modes a print mode for a whole page of a document to be printed dependent on a print material coverage of the whole page of the document to be printed.

摘要翻译： 描述了一种方法和打印装置。 该方法和打印装置允许根据要打印的文档的整个页面的打印材料覆盖，从多个打印模式中选择要打印的文档的整个页面的打印模式。

公开(公告)号：US20110292111A1

公开(公告)日：2011-12-01

申请号：US12789808

申请日：2010-05-28

申请人： Sergio PUIGARDEU ,  Luis Garcia ,  M. Isabel Borrell ,  Marc Serra ,  Angel Martinez

发明人： Sergio PUIGARDEU ,  Luis Garcia ,  M. Isabel Borrell ,  Marc Serra ,  Angel Martinez

IPC分类号： B41J29/38

CPC分类号： B41J2/2135

摘要： In a method for printing a plurality of pixels, each pixel of a plurality of pixels is printed by controlling an inkjet print head to provide for each pixel at least two ink drops at different positions in a print head movement direction, the print head having a plurality of trenches supplying ink to a plurality of sets of nozzles. The at least two ink drops forming first pixels of said plurality of pixels are fired from the same trench.

摘要翻译： 在打印多个像素的方法中，通过控制喷墨打印头来打印多个像素的每个像素，以在打印头移动方向上的不同位置处为每个像素提供至少两个墨滴，打印头具有 多个沟槽将墨水供应到多组喷嘴。 形成所述多个像素的第一像素的至少两个墨滴从相同的沟槽被烧制。