公开(公告)号：US5105036A

公开(公告)日：1992-04-14

申请号：US651715

申请日：1991-02-06

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J31/02 ,  B01J31/28 ,  C07B61/00 ,  C07C17/12 ,  C07C25/02

CPC classification number: C07C17/12

Abstract: Aromatic hydrocarbons monosubstituted by straight-chain or branched C.sub.1 -C.sub.12 -alkyl or by Chd 3-C.sub.8 -cycloalkyl can be chlorinated in the aromatic ring in the liquid phase in the presence of Friedel-Crafts catalysts if cyclic amidines which are oxy-sustituted on the exocyclic N atom are employed as co-catalysts. An increased proportion of the p-isomer is obtained in this reaction.

Abstract translation: 在Friedel-Crafts催化剂存在下，通过直链或支链C1-C12烷基或由Chd 3-C8-环烷基单取代的芳族烃可以在芳烃环中被氯化，如果环状脒被羟基维持在 外环N原子用作助催化剂。 在该反应中获得了比例增加的对异构体。

公开(公告)号：US4956505A

公开(公告)日：1990-09-11

申请号：US375761

申请日：1989-07-05

Applicant: Franz-Josef Mais ,  Helmut Fiege ,  Karl-Wilhelm Henneke

Inventor： Franz-Josef Mais ,  Helmut Fiege ,  Karl-Wilhelm Henneke

IPC: C07C45/00 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C45/78 ,  C07C45/82 ,  C07C49/223 ,  C07C49/233 ,  C07C49/235 ,  C07C67/00

CPC classification number: C07C49/235 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C45/78 ,  C07C45/82 ,  C07C49/223

Abstract: 4,4-Dimethyl-1-(p-chlorophenyl)pentan-3-one can be prepared by condensation of pinacolone and p-chlorobenzaldehyde in an alcohol as solvent in the presence of an inorganic base and by subsequent hydrogenation, in which the reaction mixture obtained in the condensation is hydrogenated directly without isolation of the intermediate 4,4-dimethyl-1-(p-chlorophenyl)-1-penten-3-one after the addition of a hydrogenation catalyst at elevated temperature and superatmospheric pressure to give 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one, after the hydrogenation catalyst has been separated off from the liquid hydrogenation mixture, the alcohol is largely distilled off, and the water content of the bottom product of the distillation is adjusted in such a manner that it separates into an aqueous and an organic phase, and the 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one is recovered from the organic phase.

Abstract translation: 4,5-二甲基-1-（对氯苯基）戊-3-酮可以通过频多卡酮和对氯苯甲醛在醇作为溶剂中，在无机碱存在下并通过随后的氢化进行缩合来制备，其中反应 在高温和超大气压下加入氢化催化剂后，在冷凝中获得的混合物直接氢化直接分离中间体4,4-二甲基-1-（对氯苯基）-1-戊烯-3-酮，得到4 ，4-二甲基-1-（对氯苯基）戊-3-酮，在氢化催化剂与液体氢化混合物分离后，大部分蒸馏除去醇，蒸馏塔底产物的含水量 以分离成水相和有机相的方式进行调节，从有机相中回收4,4-二甲基-1-（对氯苯基）戊-3-酮。

公开(公告)号：US4925994A

公开(公告)日：1990-05-15

申请号：US342500

申请日：1989-04-24

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J31/30 ,  C07B61/00 ,  C07C17/00 ,  C07C17/12 ,  C07C25/02 ,  C07C25/18 ,  C07C67/00

CPC classification number: C07C17/12

Abstract: Aromatic hydrocarbons which are monosubstituted by straight-chain or branched C.sub.1 -C.sub.12 -alkyl or by C.sub.3 -C.sub.8 -cycloalkyl can be chlorinated in the presence of Friedel-Crafts Catalysts in liquid phase on the aromatic ring if 1,6-benzothiazocins are used as co-catalysts. This makes it possible to obtain a higher proportion of p-isomers.

Abstract translation: 通过直链或支链的C 1 -C 12 - 烷基或C 3 -C 8 - 环烷基单取代的芳族烃可以在芳环上的液相中的Friedel-Crafts催化剂存在下进行氯化，如果使用1,6-苯并噻唑作为 助催化剂。 这使得可以获得较高比例的对异构体。

公开(公告)号：US4871484A

公开(公告)日：1989-10-03

申请号：US50993

申请日：1987-05-15

Applicant: Helmut Fiege ,  Manfred Jautelat ,  Dieter Arlt

Inventor： Helmut Fiege ,  Manfred Jautelat ,  Dieter Arlt

IPC: C07C53/50 ,  C07C51/00 ,  C07C51/58 ,  C07C51/60 ,  C07C51/62 ,  C07C67/00

CPC classification number: C07C51/58

Abstract: A process for the preparation of a 2,2-bis-chloro-methyl-alkanecarboxylic acid of the formula ##STR1## in which R is hydrogen, alkyl, cycloalkyl or optionally substituted phenyl,which comprises reacting an oxetane-3-carboxylic acid of the formula ##STR2## or a salt thereof, with an inorganic acid chloride at a temperature between 20.degree. C. and the boiling point of the reaction mixture. The products are known intermediates for fungicides and herbicides.

Abstract translation: 一种制备式“IMAGE”的2,2-双氯 - 甲基 - 链烷羧酸的方法，其中R是氢，烷基，环烷基或任选取代的苯基，其中包括使氧杂环丁烷-3-羧酸 式中的“IMAGE”或其盐与无机酰氯在20℃和反应混合物的沸点之间。 该产品是用于杀真菌剂和除草剂的已知中间体。

公开(公告)号：US4824975A

公开(公告)日：1989-04-25

申请号：US49749

申请日：1987-05-13

Applicant: Helmut Fiege ,  Manfred Jautelat ,  Dieter Arlt

Inventor： Helmut Fiege ,  Manfred Jautelat ,  Dieter Arlt

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/42 ,  B01J23/44 ,  C07C53/50 ,  C07D305/08

CPC classification number: C07C53/50 ,  C07D305/08

Abstract: A process for the preparation of an oxetane-3-carboxylic acid of the formula ##STR1## in which R represents hydrogen, alkyl, cycloalkyl or optionally substitute phenyl, comprising reacting a 3-hydroxymethyl-oxetane of the formula ##STR2## with oxygen in an aqueous alkaline medium at a temperature between about 0.degree. C. and the boiling point of the reaction mixture on a palladium and/or platinum catalyst. The product is an intermediate for known fungicides and herbicides.

Abstract translation: 制备式“IMAGE”的氧杂环丁烷-3-羧酸的方法，其中R表示氢，烷基，环烷基或任选取代的苯基，包括使式“IMAGE”的3-羟甲基 - 氧杂环丁烷与氧反应 在约0℃的温度和钯和/或铂催化剂上的反应混合物的沸点之间的碱性水溶液。 该产品是已知杀真菌剂和除草剂的中间体。