公开(公告)号：US5470960A

公开(公告)日：1995-11-28

申请号：US371564

申请日：1995-01-11

申请人： Koichi Niimura ,  Takako Kawabe ,  Takao Ando ,  Kenichi Saito

发明人： Koichi Niimura ,  Takako Kawabe ,  Takao Ando ,  Kenichi Saito

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07C271/18 ,  C07C271/22 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07H15/24 ,  C07C229/00

CPC分类号： C07K5/06078 ,  C07C271/22 ,  A61K38/00

摘要： A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of the phenylalanine-glycine derivative and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered singly or as a mixture with phenylalanine.

摘要翻译： 通式（I）的苯丙氨酸 - 甘氨酸衍生物：其中R表示抗肿瘤物质的残基或其盐或酯，其制备方法和含有它们的药物组合物为 描述。 苯丙氨酸 - 甘氨酸衍生物与抗肿瘤物质的新结合物与单独给予抗肿瘤物质或与苯丙氨酸的混合物相比，具有优异的抗肿瘤活性。

公开(公告)号：US4975422A

公开(公告)日：1990-12-04

申请号：US368232

申请日：1989-06-19

申请人： Tamotsu Kanoh ,  Kenichi Matsunaga ,  Kenichi Saito ,  Takayoshi Fujii

发明人： Tamotsu Kanoh ,  Kenichi Matsunaga ,  Kenichi Saito ,  Takayoshi Fujii

IPC分类号： A61K36/07 ,  A61K36/06 ,  A61K38/00 ,  A61P9/00 ,  A61P27/02 ,  A61P35/00 ,  C07K14/375

CPC分类号： C07K14/375 ,  A61K38/00

摘要： The present invention discloses an angiogenesis inhibitor containing as an active ingredient protein-polysaccharides produced by extraction of mycelia or fruit bodies obtained from culture of a Basidiomycete belonging to a genus Coriolus.The protein-polysaccharide contains about 18 to about 38% by weight of protein, being free from protein-polysaccharides having molecular weight of less than 5,000.More in detail, said protein-polysaccharides of the present invention contain 3 to 6% of nitrogen, a polysaccharide portion thereof, as the main fraction, is composed of .beta.-D-glucan and this glucan portion has branched structures containing 1.fwdarw.3, 1.fwdarw.4 and 1.fwdarw.6 bonds, wherein the protein-component amino acids are mostly acidic amino acids of aspartic acid and glutamic acid, and neutral amino acids of valine and leucine, while the basic amino acids of lysine and alginine are small in content, and the protein-polysaccharide is soluble in water but hardly soluble in methanol, pyridine, chloroform, benzene and hexane and starts to be gradually decomposed at about 120.degree. C.

公开(公告)号：US4628050A

公开(公告)日：1986-12-09

申请号：US800114

申请日：1985-11-20

申请人： Yuji Maeda ,  Hideyuki Yamato ,  Takayoshi Fujii ,  Yasuhiko Kobayashi ,  Kenichi Saito ,  Tadaaki Kato ,  Chikao Yoshikumi

发明人： Yuji Maeda ,  Hideyuki Yamato ,  Takayoshi Fujii ,  Yasuhiko Kobayashi ,  Kenichi Saito ,  Tadaaki Kato ,  Chikao Yoshikumi

IPC分类号： A61K31/59 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K31/59

摘要： Disclosed herein is a pharmaceutical composition in dosage unit form, which comprises a dosage effective for treating nephritic disease of a compound of 24,25-dihydroxycholecalciferol as an active ingredient and a pharmaceutically acceptable carrier.

摘要翻译： 本文公开了以剂量单位形式的药物组合物，其包含有效治疗24,25-二羟基胆钙化甾醇化合物作为活性成分的肾炎疾病的剂量和药学上可接受的载体。

公开(公告)号：US08746884B2

公开(公告)日：2014-06-10

申请号：US13256794

申请日：2010-04-08

申请人： Kenichi Saito

发明人： Kenichi Saito

IPC分类号： A61B3/10 ,  A61B3/14

CPC分类号： A61B3/14 ,  A61B3/1015 ,  A61B3/107 ,  A61B3/12 ,  G02B26/06

摘要： The present invention provides an optical image acquisition apparatus, while controlling the amount of light within the range prescribed by safety standards, etc., decreasing in image acquisition time by using a simple configuration, as well as securing a high resolution of an optical image by using adaptive optics.Provided is an optical image acquisition apparatus having adaptive optics, the adaptive optics includes: a wavefront aberration detector for detecting a wavefront aberration in a reflected or backscattered beams generated when a plurality of beams are scanned on a surface, and a single wavefront aberration corrector for correcting a wavefront aberration in each of the plurality of beams, based on the wavefront aberration, and the plurality of beams enter the single wavefront aberration corrector with different incident angles and are overlapped on each other, and the wavefront aberration in each of the plurality of beams is corrected.

摘要翻译： 本发明提供一种光学图像获取装置，同时通过使用简单的配置控制在安全标准等规定的范围内的光量，减少图像获取时间，并且通过以下方式确保光学图像的高分辨率 使用自适应光学。 提供了一种具有自适应光学器件的光学图像采集装置，该自适应光学装置包括：波面像差检测器，用于检测当在表面上扫描多个光束时产生的反射或反向散射光束中的波前像差;以及单个波前像差校正器， 基于所述波前像差校正所述多个光束中的每一个中的波前像差，并且所述多个光束以不同的入射角进入所述单个波前像差校正器，并且彼此重叠，并且所述多个光束中的每一个中的波前像差 光束被校正。

公开(公告)号：US20140055748A1

公开(公告)日：2014-02-27

申请号：US14112968

申请日：2012-04-20

申请人： Kenichi Saito

发明人： Kenichi Saito

IPC分类号： A61B3/14

CPC分类号： A61B3/1015 ,  A61B3/12 ,  A61B3/14

摘要： A fundus imaging apparatus comprising: position detection means for detecting a position of a pupil of an eye to be examined; wavefront detection means for detecting a wavefront of return light from the eye irradiated with light through an illumination optical system; correction means for correcting an aberration based on the detected wavefront; and determination means for determining a correction effective region of the correction means based on the detected position.

摘要翻译： 一种眼底成像装置，包括：位置检测装置，用于检测被检眼睛的瞳孔的位置; 用于通过照明光学系统检测来自用光照射的眼睛的返回光的波前的波前检测装置; 用于基于检测到的波前校正像差的校正装置; 以及确定装置，用于基于检测到的位置确定校正装置的校正有效区域。

公开(公告)号：US20130266465A1

公开(公告)日：2013-10-10

申请号：US13989621

申请日：2011-12-12

申请人： Tatsuhiko Akita ,  Kenichi Saito

发明人： Tatsuhiko Akita ,  Kenichi Saito

IPC分类号： F04B7/02

CPC分类号： F04B7/02 ,  F02M53/00 ,  F02M55/04 ,  F02M59/44 ,  F02M2200/9015

摘要： A high-pressure pump includes a plunger capable of reciprocating, and a housing having a pressurizing chamber in which fuel is pressurized by the plunger, and a fuel chamber through which the fuel flows toward and from the pressurizing chamber. The pump includes a spring that biases the plunger so as to increase the volume of the pressurizing chamber, and a spring seat that is fixed to the housing and is in contact with one end of the spring. A first space that communicates with the fuel chamber via a fuel passage is provided between the bottom of the spring seat and the housing, and a top face of the bottom exposed to the first space is covered with a heating insulating member.

摘要翻译： 高压泵包括能够往复运动的柱塞和具有加压室的壳体，在所述加压室中燃料被柱塞加压，以及燃料室，燃料通过该燃料室朝向和从加压室流出。 泵包括弹簧，该弹簧偏压柱塞以增加加压室的容积;以及弹簧座，其固定到壳体并与弹簧的一端接触。 在弹簧座的底部和壳体之间设置有经由燃料通路与燃料室连通的第一空间，暴露于第一空间的底部的顶面被绝热构件覆盖。

公开(公告)号：US08462502B2

公开(公告)日：2013-06-11

申请号：US12994656

申请日：2010-11-09

申请人： Kazuya Hirano ,  Takashi Chikusa ,  Hiroyuki Kumasawa ,  Kenichi Saito

发明人： Kazuya Hirano ,  Takashi Chikusa ,  Hiroyuki Kumasawa ,  Kenichi Saito

IPC分类号： H05K5/00 ,  H05K7/16 ,  A47B81/00

CPC分类号： G11B33/128 ,  G06F1/187 ,  G06F1/20 ,  G06F3/0658 ,  G11B33/142

摘要： A storage device mounting structure with excellent handleability for storage devices is provided.A storage device mounting structure according to this invention includes a unit for housing a plurality of storage devices, a chassis for housing the unit, and a guide mechanism for supporting the unit and guiding it into or out of the chassis, wherein the unit has an open area for inserting the plurality of storage devices from a front face of the unit into the unit and is supported by the guide mechanism so that the unit can freely move rotationally to make a surface of the unit, where the open area exists, positioned at the front of the chassis.

摘要翻译： 提供了一种存储装置的具有优异的可操作性的存储装置安装结构。 根据本发明的存储装置安装结构包括：用于容纳多个存储装置的单元，用于容纳该单元的底盘;以及用于支撑该单元并将其引导到底架中的引导机构，其中该单元具有 用于将多个存储装置从单元的前表面插入到单​​元中的开放区域，并且被引导机构支撑，使得该单元可以自由地旋转移动，以使开放区域存在的单元的表面位于 机箱的前部。

公开(公告)号：US08419187B2

公开(公告)日：2013-04-16

申请号：US12907756

申请日：2010-10-19

申请人： Kenichi Saito

发明人： Kenichi Saito

IPC分类号： A61B3/14 ,  A61B3/10 ,  A61B3/00

CPC分类号： A61B3/0008 ,  A61B3/12 ,  A61B3/14 ,  G02B26/06 ,  G02B27/286

摘要： An adaptive optics apparatus includes a first light modulating unit configured to perform modulation in a polarization direction of one of two polarized light components in light emitted from a light source, a changing unit configured to rotate the light modulated by the first light modulating unit by 90 degrees, a second light modulating unit configured to modulate the light changed by the changing unit in the polarization direction, and an irradiating unit configured to irradiate a measurement object with the light modulated by the second light modulating unit.

摘要翻译： 一种自适应光学装置包括：第一光调制单元，被配置为在从光源发射的光中的两个偏振光分量之一的偏振方向上执行调制;改变单元，被配置为将由第一光调制单元调制的光旋转90 第二光调制单元，被配置为在偏振方向上调制由改变单元改变的光;以及照射单元，被配置为用由第二光调制单元调制的光照射测量对象。

公开(公告)号：US20130021576A1

公开(公告)日：2013-01-24

申请号：US13639268

申请日：2011-04-12

申请人： Kenichi Saito

发明人： Kenichi Saito

IPC分类号： A61B3/12

CPC分类号： A61B3/12

摘要： Provided is an ocular optical system, which permits a measuring beam scanned by two scanning units disposed close to each other to enter an anterior ocular segment of an eye to be inspected and to irradiate a fundus. The ocular optical system includes an optical unit which is disposed at a position of an intermediate image, which is optically conjugate to the fundus, and has a surface having different optical powers corresponding to scan directions of the two scanning units.

摘要翻译： 提供了一种眼睛光学系统，其允许通过彼此靠近设置的两个扫描单元扫描的测量光束进入要检查的眼睛的前眼部分并照射眼底。 眼睛光学系统包括光学单元，其设置在与眼底光学共轭的中间图像的位置处，并且具有与两个扫描单元的扫描方向对应的具有不同光功率的表面。

公开(公告)号：US08230118B2

公开(公告)日：2012-07-24

申请号：US12586587

申请日：2009-09-24

申请人： Kazuaki Toba ,  Gen Ichimura ,  Kenichi Saito

发明人： Kazuaki Toba ,  Gen Ichimura ,  Kenichi Saito

IPC分类号： G06F3/00 ,  G06F13/00

CPC分类号： G09G5/006 ,  G09G2370/12 ,  H04L25/0272 ,  H04N5/775

摘要： An interface circuit includes: a first transmitting section transmitting a first signal as an in-phase signal to an external device through a transmission path; and a second transmitting section transmitting a clock signal, which is synchronized with the first signal to be transmitted by the first transmitting section, as a differential signal to the external device through the transmission path.

摘要翻译： 接口电路包括：第一发送部分，通过传输路径向外部设备发送作为同相信号的第一信号; 以及第二发送部，其将与由第一发送部发送的第一信号同步的时钟信号作为差分信号通过发送路径发送到外部装置。