公开(公告)号：US20070243615A1

公开(公告)日：2007-10-18

申请号：US11809655

申请日：2007-06-01

Applicant: Guang Qu ,  John Wright

Inventor： Guang Qu ,  John Wright

IPC: C12N15/861

CPC classification number: C12N15/86 ,  C12N7/00 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions.

Abstract translation: 描述了从AAV载体颗粒和AAV空衣壳的混合物中分离AAV空衣壳的方法。 该方法使用柱色谱技术并提供商业上可行的重组AAV病毒粒子水平。

公开(公告)号：US20070151235A1

公开(公告)日：2007-07-05

申请号：US11325370

申请日：2006-01-03

Applicant: John Wright

Inventor： John Wright

IPC: F16D31/02

CPC classification number: F15B20/002 ,  F15B2211/20538 ,  F15B2211/212 ,  F15B2211/30505 ,  F15B2211/3051 ,  F15B2211/3127 ,  F15B2211/8623 ,  F15B2211/8752 ,  F15B2211/8757

Abstract: A block manifold for a fail safe actuator system allows the actuator operation with a hand pump if electrical power were not available. A method is available to isolate fail safe solenoid valves and an accumulator from a hand pump circuit to relieve the stored energy from the fail safe circuit. An additional set of pilot operated check valves were installed between the motor driven pump circuit and the hand pump circuit. These pilot operated check valves isolated the hand pump circuit from the fail safe dump solenoid and accumulator. These pilot actuated check valves also hold the actuator in the fail safe position as long as the hand pump system was not used. There is also a hydraulic bleed circuit to relieve the accumulator stored energy when the hand pump system was used.

Abstract translation: 用于故障安全执行器系统的块歧管允许在没有电力的情况下使用手动泵进行执行器操作。 一种方法可用于隔离来自手动泵电路的故障安全电磁阀和蓄能器，以便从故障安全回路中释放存储的能量。 在电机驱动泵电路和手动泵电路之间安装了一组先导式止回阀。 这些先导式止回阀将手泵电路与故障安全转储电磁阀和蓄电池隔离。 只要不使用手动泵系统，这些先导式止回阀也将执行器保持在故障安全位置。 当使用手动泵系统时，还有一个液压泄放电路可以缓解蓄能器的储存能量。

公开(公告)号：US20070042154A1

公开(公告)日：2007-02-22

申请号：US11586922

申请日：2006-10-26

Applicant: Mehmet Hancer ,  Jane Gates ,  Joel Hoehn ,  Fang Chen ,  Marsha Huha ,  John Wright ,  Lee Walter

Inventor： Mehmet Hancer ,  Jane Gates ,  Joel Hoehn ,  Fang Chen ,  Marsha Huha ,  John Wright ,  Lee Walter

IPC: B32B3/02

CPC classification number: C23C26/00 ,  B05D1/185 ,  B82Y30/00 ,  B82Y40/00 ,  G11B5/3106 ,  G11B5/72 ,  G11B5/8408 ,  Y10T428/21

Abstract: A protective coating for a substrate includes a diamond-like carbon (DLC) layer overlying the substrate and having gaps where the substrate is not protected by the diamond-like carbon layer. The protective coating also includes a self-assembled monolayer formed in the gaps of the diamond-like carbon layer.

Abstract translation: 用于衬底的保护涂层包括覆盖衬底的类金刚石碳（DLC）层，并且具有衬底未被类金刚石碳层保护的间隙。 保护涂层还包括在类金刚石碳层的间隙中形成的自组装单层。

公开(公告)号：US20070021466A1

公开(公告)日：2007-01-25

申请号：US11486395

申请日：2006-07-13

Applicant: Solomon Ungashe ,  John Wright ,  Andrew Pennell ,  Zheng Wei ,  Anita Melikian

Inventor： Solomon Ungashe ,  John Wright ,  Andrew Pennell ,  Zheng Wei ,  Anita Melikian

IPC: A61K31/444 ,  A61K31/44

CPC classification number: C07D213/50

Abstract: Compounds are provided that act as potent antagonists of the CCR2 receptor. These compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

Abstract translation: 提供了作为CCR2受体的有效拮抗剂的化合物。 这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。

公开(公告)号：US20060267343A1

公开(公告)日：2006-11-30

申请号：US11489487

申请日：2006-07-20

Applicant: John Wright

Inventor： John Wright

IPC: F16L21/06

CPC classification number: F16L21/08 ,  F16L17/04 ,  F16L21/005

Abstract: The invention relates to a pipe coupling for rigid plastics pipes having smooth cylindrical ends. The coupling includes a rigid sleeve having a longitudinal bore. Two spaced apart annular grooves are provided in the bore to respectively house deformable annular seals adjacent the ends of the sleeve. O-rings will be used as seals. A harness is securable over the sleeve with pipe engaging teeth adjacent each of the opposite ends. The harness is split longitudinally with a cylindrical passage having an annular recess to receive the sleeve. The teeth are formed by serrated ridges, preferably screw threads, in the passage extending from the recess to the outer ends of the passage. Corresponding lateral lugs on each half of the harness have bolt holes for assembly of the harness over the sleeve. The coupling is particularly suited for connecting plastics pipes used to convey backfill, normally in underground mining operations.

Abstract translation: 本发明涉及一种具有光滑圆柱端的刚性塑料管的管接头。 联轴器包括具有纵向孔的刚性套筒。 在孔中设置两个间隔开的环形槽，以分别容纳与套筒端部相邻的可变形环形密封件。 O形圈将用作密封件。 线束可以在套筒上固定，管子与相邻端部相邻的齿相啮合。 线束纵向分开，圆柱形通道具有环形凹槽以接收套筒。 齿在通道中从凹槽延伸到通道的外端的通道中形成有锯齿状的脊，优选是螺纹。 线束的每一半上的相应的横向凸耳具有用于将线束组装在套筒上的螺栓孔。 联轴器特别适用于连接用于传送回填物的塑料管道，通常在地下采矿作业中。

公开(公告)号：US20060245110A1

公开(公告)日：2006-11-02

申请号：US11115659

申请日：2005-04-27

Applicant: Jorge Hanchi ,  Dian Song ,  John Wright ,  Andrew White

Inventor： Jorge Hanchi ,  Dian Song ,  John Wright ,  Andrew White

IPC: G11B5/60

CPC classification number: G11B5/6005 ,  G11B5/6058 ,  G11B5/607 ,  G11B5/6076

Abstract: A head assembly having a sensor element on the head assembly. Embodiments of the sensor element are configured to detect non-contact induced head-media interface instability, “onset of contact” or low level interference. The non-contact head-media instability or interference is detected based upon sensor feedback relating to excitation of the air bearing resonance modes of the slider body. In embodiments of the present invention, the sensor head assembly includes a microactuator which is energizable to microactuate the head or transducer elements on the head assembly.

公开(公告)号：US20060227463A1

公开(公告)日：2006-10-12

申请号：US11102055

申请日：2005-04-08

Applicant: John Wright ,  Jagdish Agrawal ,  Zine-Eddine Boutaghou ,  Joseph Sassine ,  Andrew White

Inventor： John Wright ,  Jagdish Agrawal ,  Zine-Eddine Boutaghou ,  Joseph Sassine ,  Andrew White

IPC: G11B5/48

CPC classification number: G11B5/4833

Abstract: A support assembly includes a base layer, a circuit defined along the base layer, and a first material molded on at least a portion of the base layer. The first material substantially forms a shape of at least a portion of the support assembly. Further disclosed is a molded suspension assembly. The molded suspension assembly includes a thin and elongate metallic substrate and a non-metallic material molded along at least a portion of one side of the metallic substrate. The non-metallic material interlocks with the metallic substrate. The molded suspension assembly includes a transducer support area at or near a first end of the molded suspension assembly.

Abstract translation: 支撑组件包括基底层，沿基底层限定的电路以及模制在基底层的至少一部分上的第一材料。 第一材料基本上形成支撑组件的至少一部分的形状。 进一步公开的是模制悬挂组件。 模制的悬挂组件包括薄且细长的金属基底和沿着金属基底的一侧的至少一部分模制的非金属材料。 非金属材料与金属基底互锁。 模制的悬挂组件包括在模制的悬挂组件的第一端处或附近的换能器支撑区域。

公开(公告)号：US20060111351A1

公开(公告)日：2006-05-25

申请号：US11255163

申请日：2005-10-20

Applicant: Solomon Ungashe ,  John Wright ,  Andrew Pennell ,  Zheng Wei ,  Anita Melikian

Inventor： Solomon Ungashe ,  John Wright ,  Andrew Pennell ,  Zheng Wei ,  Anita Melikian

IPC: A61K31/5377 ,  C07D413/02

CPC classification number: C07D213/50 ,  C07D213/26 ,  C07D213/52 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D405/12 ,  C07D413/12

Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

公开(公告)号：US20060063188A1

公开(公告)日：2006-03-23

申请号：US11228042

申请日：2005-09-15

Applicant: Martin Zanni ,  John Wright ,  Eric Fulmer

Inventor： Martin Zanni ,  John Wright ,  Eric Fulmer

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G01N33/542 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/636 ,  G01N21/65 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/3125 ,  G01N2021/653

Abstract: This invention provides methods and devices for identifying and/or characterizing interactions involving molecules, including, but not limited to, identifying and/or characterizing interactions involving target molecules and candidate molecules. The present invention provides methods using multidimensional infrared spectrographic techniques, such as four wave mixing and pump-probe techniques, for identifying interactions involving biomolecules and therapeutic candidate molecules, and for characterizing such interactions in terms of their binding coefficients and/or equilibrium constants.

Abstract translation: 本发明提供用于鉴定和/或表征涉及分子的相互作用的方法和装置，包括但不限于识别和/或表征涉及靶分子和候选分子的相互作用。 本发明提供使用多维红外光谱技术的方法，例如四波混合和泵浦探针技术，用于鉴定涉及生物分子和治疗候选分子的相互作用，以及根据其结合系数和/或平衡常数来表征这些相互作用。

公开(公告)号：US20060025036A1

公开(公告)日：2006-02-02

申请号：US10901002

申请日：2004-07-27

Applicant: Brendan Boyle ,  Matt Adams ,  Stephen Brock ,  Katherine Burch ,  Alexander Coriano ,  Chris Countryman ,  Thomas Craven ,  Kenneth Dinkin ,  Maryann Duringer ,  Peter Finn ,  Jeffrey Grant ,  Vandana Mehra ,  S. Olefsky ,  Adam Skaates ,  Andrew Switky ,  John Wright

Inventor： Brendan Boyle ,  Matt Adams ,  Stephen Brock ,  Katherine Burch ,  Alexander Coriano ,  Chris Countryman ,  Thomas Craven ,  Kenneth Dinkin ,  Maryann Duringer ,  Peter Finn ,  Jeffrey Grant ,  Vandana Mehra ,  S. Olefsky ,  Adam Skaates ,  Andrew Switky ,  John Wright

IPC: A63H30/00

CPC classification number: G06F3/04886

Abstract: An interactive electronic device is disclosed, wherein the device includes a body, a controller disposed within the body, a touch-screen input coupled with the body, wherein the touch-screen input includes a transparent viewing field, a display output coupled with the body, wherein the display output includes a transparent portion positioned within the viewing field of the touch-screen input, and a background disposed behind the touch-screen input and the display output, the background including activity content, wherein the controller is configured to accept an input from the touch-screen input and to control the display of an output on the transparent portion of the display output.

Abstract translation: 公开了一种交互式电子设备，其中所述设备包括主体，设置在所述主体内的控制器，与所述主体耦合的触摸屏输入，其中所述触摸屏输入包括透明视野，与所述主体耦合的显示输出 ，其中所述显示输出包括位于所述触摸屏输入的视野内的透明部分，以及设置在所述触摸屏输入和所述显示器输出之后的背景，所述背景包括活动内容，其中所述控制器被配置为接受 从触摸屏输入输入并控制显示输出的透明部分上的输出的显示。