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    CARRYING CASE WITH BACKBONE
    81.
    发明申请
    CARRYING CASE WITH BACKBONE 审中-公开
    携带背板

    公开(公告)号：US20090140017A1

    公开(公告)日：2009-06-04

    申请号：US12043600

    申请日：2008-03-06

    Applicant: Michael Boyd ,  Dennis Balchunas ,  Richard N. Case

    Inventor： Michael Boyd ,  Dennis Balchunas ,  Richard N. Case

    IPC: A45F5/00 ,  A45C11/00 ,  D05B23/00

    CPC classification number: A45F5/02 ,  A45C15/06 ,  A45F5/021 ,  A45F2005/025 ,  A45F2200/0566

    Abstract: A carrying case includes a backbone panel forming a back and base for the carrying case. A rear-top panel is connected to the backbone panel forming at least a portion of the sides and top of the carrying case. A left side and a right side panel are connected to the backbone panel forming a portion of the left side and right side of the carrying case, respectively. A mid-top panel is connected to the left side and right side panels, forming a portion of the sides and top of the carrying case. A mid-front panel is connected to the mid-top panel, the left side and right side panels, and the backbone panel, the mid-front panel forming the front of the carrying case. A first zipper is connected to the rear-top panel and the mid-top panel. The backbone panel, rear-top panel, left side and right side panels, mid-top panel, mid-front panel, and zipper form a first pocket in the carrying case.

    Abstract translation: 手提箱包括形成用于手提箱的背部和底座的主干板。 后顶板连接到骨架板，形成手提箱的侧面和顶部的至少一部分。 左侧面板和右侧面板分别与便携箱的左侧面和右侧的一部分分别连接在主干板上。 中顶板连接到左侧板和右侧板，形成手提箱的侧面和顶部的一部分。 中前面板连接到中顶板，左侧和右侧板以及主干板，中间前面板形成手提箱的前部。 第一个拉链连接到后顶板和中顶板。 主干面板，后排面板，左侧面板和右侧面板，中顶板，中前面板和拉链在手提箱中形成第一个口袋。

    Indole Amide Derivatives as Ep4 Receptot Ligands
    83.
    发明申请
    Indole Amide Derivatives as Ep4 Receptot Ligands 有权
    吲哚酰胺衍生物作为Ep4 Receptot配体

    公开(公告)号：US20090105321A1

    公开(公告)日：2009-04-23

    申请号：US12227280

    申请日：2007-06-08

    Applicant: Michael Boyd ,  John Colucci

    Inventor： Michael Boyd ,  John Colucci

    IPC: A61K31/404 ,  C07D209/08 ,  A61K31/41 ,  C07D403/12 ,  A61P29/00

    CPC classification number: C07D209/08 ,  C07D403/12

    Abstract: The invention is directed to indoline amide derivatives as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included.

    Abstract translation: 本发明涉及可用于治疗EP4介导的疾病或病症如急性和慢性疼痛，骨关节炎，类风湿性关节炎，癌症和青光眼的EP4受体配体，拮抗剂或激动剂的二氢吲哚酰胺衍生物。 还包括药物组合物和使用方法。

    CYANOVIRIN VARIANT-POLYMER CONJUGATES
    86.
    发明申请
    CYANOVIRIN VARIANT-POLYMER CONJUGATES 有权
    CYANOVIRIN变体聚合物共轭体系（CYANOVIRIN VARIANT-POLYMER CONJUGATES）

    公开(公告)号：US20080015151A1

    公开(公告)日：2008-01-17

    申请号：US11832925

    申请日：2007-08-02

    Applicant: M. Snell ,  Michael Roberts ,  Toshiyuki Mori ,  Barry O'Keefe ,  Michael Boyd

    Inventor： M. Snell ,  Michael Roberts ,  Toshiyuki Mori ,  Barry O'Keefe ,  Michael Boyd

    IPC: A61K38/00

    CPC classification number: C07K14/195

    Abstract: The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof, and methods of preparing such conjugates. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.

    Abstract translation: 本发明提供了氰尿素-N和其水溶性聚合物共轭物的变体，以及制备这种缀合物的方法。 本发明的氰尿素-N特别适用于一种或多种水溶性聚合物的位点选择性共价连接，以提供显示抗病毒活性的氰尿酸-N变体的聚合物缀合物。

    Scytovirins and related conjugates, fusion proteins, nucleic acids, vectors, host cells, compositions, antibodies and methods of using scytovirins
    88.
    发明申请
    Scytovirins and related conjugates, fusion proteins, nucleic acids, vectors, host cells, compositions, antibodies and methods of using scytovirins 失效

    公开(公告)号：US20050084496A1

    公开(公告)日：2005-04-21

    申请号：US10513961

    申请日：2003-05-15

    Applicant: Michael Boyd ,  Heidi Bokesch ,  Barry O'Keefe ,  Tawnya McKee

    Inventor： Michael Boyd ,  Heidi Bokesch ,  Barry O'Keefe ,  Tawnya McKee

    IPC: A61K38/00 ,  A61K39/12 ,  C07K14/195 ,  C07K14/435 ,  C12P21/04

    CPC classification number: C07K14/195 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/00

    Abstract: An isolated or purified antiviral protein consisting essentially of the amino acid sequence of SEQ ID NO: 1, an amino acid sequence that is about 90% or more identical to SEQ ID NO: 1, an amino acid sequence that is about 90% or more homologous to SEQ ID NO: 1, or an antiviral fragment of any of the foregoing; a variant, fusion protein or conjugate thereof; a composition comprising (i) at least one of the foregoing and (ii) a carrier, excipient or adjuvant: an isolated or purified nucleic acid consisting essentially of a nucleotide sequence encoding the amino acid sequence of the aforementioned antiviral protein or antiviral fragment thereof, or a variant or fusion protein of either of the foregoing; an isolated cell comprising an above-described isolated or purified nucleic acid; a composition comprising (i) an above-described isolated or purified nucleic acid, and (ii) a carrier, excipient or adjuvant; a method of inhibiting a viral infection of a host comprising administering a viral infection-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, a variant or fusion protein of either of the foregoing, an above-described nucleic acid, or an isolated cell comprising an abovedescribed nucleic acid; a method of inhibiting a virus in a biological sample or in/on an inanimate object comprising contacting the biological sample or the inanimate object with a viral-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, or a variant, fusion protein or conjugate of either of the foregoing, antibodies and composition thereof, and a method of inhibiting infection of a mammal with a virus comprising administering to the mammal an anti-scytovirin antibody in an amount sufficient to induce in the mammal an immune response to the virus.

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