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    METHODS OF EVALUATING PEPTIDE MIXTURES
    81.
    发明申请
    METHODS OF EVALUATING PEPTIDE MIXTURES 有权
    评估胶体混合物的方法

    公开(公告)号：US20090237078A1

    公开(公告)日：2009-09-24

    申请号：US12298591

    申请日：2007-04-30

    申请人： Zachary Shriver ,  Ganesh Venkataraman ,  Jonathan Lansing ,  Corrinne Bauer ,  Xiaangping Zhu

    发明人： Zachary Shriver ,  Ganesh Venkataraman ,  Jonathan Lansing ,  Corrinne Bauer ,  Xiaangping Zhu

    IPC分类号： G01N33/68 ,  G01N27/26 ,  H01J49/26 ,  G01R33/46 ,  G01J3/44 ,  G01J3/00

    CPC分类号： G01N33/9493 ,  A61K38/02 ,  G01N33/15 ,  G01N33/68 ,  G01N33/6806 ,  G01N33/6821 ,  G01N33/6848 ,  Y10T436/24 ,  Y10T436/25125

    摘要： The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.

    摘要翻译： 目前公开的主题提供了用于评估和表征肽，肽混合物和多肽混合物的方法。 更具体地，本发明公开的主题提供了用于评估或表征包含谷氨酸，丙氨酸，酪氨酸和赖氨酸的复合肽或多肽混合物的方法，例如共聚物-1或乙酸格拉默，包括但不限于鉴定， 分离，定量和纯化具有二乙基酰胺基团而不是C末端存在的羧基的氨基酸，肽，多肽及其组合。 目前公开的方法可以用于确定在C末端具有二乙酰胺基团的多肽的摩尔百分比，并且可以用于评估一种多肽混合物的样品的一种或多种性质，与一种或多种性质的 不同样品的多肽混合物。