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公开(公告)号：US08063358B2
公开(公告)日：2011-11-22
申请号：US11916430
申请日：2006-06-01
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译： 公开了一种质谱法，其中分析了来自离子检测器的电压信号。 获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。 然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。 然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。 然后将各种时间和强度数据对被整合以产生平滑的连续质谱。 然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。 可以确定在连续质谱中观察到的质量峰的开始和结束时间。 然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。 然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。
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公开(公告)号：US20100294923A1
公开(公告)日：2010-11-25
申请号：US12445774
申请日：2007-10-16
申请人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
发明人： Daniel James Kenny , Robert Harold Bateman , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译： 公开了一种碰撞或分裂单元（4），其包括多个电极，其中将第一RF电压（7a）施加到上游电极组，并且将第二不同RF电压（7b）施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池（4）的母体离子的径向约束，并且优化在碰撞或断裂电池（4）内产生的子或碎片离子的径向约束 通过施加到下游组电极的第二不同RF电压。
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公开(公告)号：US07820966B2
公开(公告)日：2010-10-26
申请号：US11909996
申请日：2006-04-03
CPC分类号： B01D59/44 , G01N30/724 , G01N2030/8447 , G01N2030/8868 , H01J49/004 , H01J49/04
摘要： A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and a Field Asymmetric Ion Mobility Spectrometry device (13). Analyte and solvent molecules are ionised by the ion source (11). Desired analyte ions are substantially onwardly transmitted by the Field Asymmetric Ion Mobility Spectrometry device (13) to the combustion chamber (16) whereas undesired solvent ions are substantially attenuated by the Field Asymmetric Ion Mobility Spectrometry device (13).
摘要翻译： 公开了一种质谱仪，其包括通过电喷雾离子源（11）和场非对称离子迁移率（11）与燃烧室（16）和同位素比质量分析器（19）相连的高压液相色谱系统（10） 光谱测定装置（13）。 分析物和溶剂分子被离子源（11）电离。 期望的分析物离子通过场非对称离子迁移率分析装置（13）基本向上传输到燃烧室（16），而不期望的溶剂离子被场非对称离子迁移率装置（13）基本上衰减。
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公开(公告)号：US20100108879A1
公开(公告)日：2010-05-06
申请号：US12514972
申请日：2007-11-15
IPC分类号： H01J49/26
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。 碰撞室（10）布置在离子门（9）的下游。 离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。
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公开(公告)号：US20100108878A1
公开(公告)日：2010-05-06
申请号：US11720771
申请日：2005-12-07
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
CPC分类号： H01J49/0045 , G01N27/622 , H01J49/004 , H01J49/022 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter (7), a collision cell (8), an ion mobility spectrometer or separator, an ion guide or collision cell (13) arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter (16) and an ion detector (15).
摘要翻译： 公开了一种质谱仪，其包括第一四极杆组质量过滤器（7），碰撞池（8），离子迁移谱仪或分离器，位于离子迁移谱仪或分离器下游的离子导向器或碰撞池（13） 第二四极杆组质量过滤器（16）和离子检测器（15）。
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公开(公告)号：US20090321628A1
公开(公告)日：2009-12-31
申请号：US12302177
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译： 公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。 从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。 每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。
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公开(公告)号：US07635841B2
公开(公告)日：2009-12-22
申请号：US10498046
申请日：2002-12-12
IPC分类号： H01J49/00
CPC分类号： H01J49/062 , Y10T436/24
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译： 公开了一种质谱法，其中在产品PxT至少为1毫巴的压力下，在保持在压力P的AC或RF离子导向器内捕获离子一段时间T。 捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的 质量分析。
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公开(公告)号：US07622711B2
公开(公告)日：2009-11-24
申请号：US11574554
申请日：2005-09-14
IPC分类号： B01D59/44
CPC分类号： H01J49/005
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或破碎电池（5）的上游的离子迁移谱仪或分离器（3）。 离子在离子迁移谱仪或分离器（3）内根据其离子迁移率分离。 离子离子迁移谱仪或分离器（3）离子的动能随时间呈线性增加，以优化离子进入碰撞或破碎电池（5）时的碎裂能。
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公开(公告)号：US20090014641A1
公开(公告)日：2009-01-15
申请号：US12094561
申请日：2006-12-07
IPC分类号： B01D59/44
CPC分类号： G01N27/622 , H01J49/062
摘要： A closed-loop ion guide (1) is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed-loop ion guide (1) and may make several circuits of the closed-loop ion guide (1) before being ejected from the ion guide (1). In a mode of operation the ion guide (1) may be arranged to separate ions temporally according to their ion mobility.
摘要翻译： 公开了一种闭环离子导向器（1），其包括具有孔的多个电极，在使用中通过该孔具有离子。 离子被注入到闭环离子导向器（1）中，并且可以在从离子导向器（1）喷射之前制造闭环离子导向器（1）的几个电路。 在操作模式中，离子导向器（1）可以被布置成根据离子迁移率暂时分离离子。
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公开(公告)号：US07417226B2
公开(公告)日：2008-08-26
申请号：US10893427
申请日：2004-07-16
IPC分类号： H01J49/10
CPC分类号： H01J49/168 , H01J49/145
摘要： An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the reaction chamber 2. Reagent ions are formed in the corona discharge chamber 1 and pass to the reaction chamber 2 via the passage 6. Analyte is sprayed into a heated tube 3. Low to moderately polar analyte molecules pass from the heated tube 3 into the reaction chamber 2 whereupon the analyte molecules are ionised by interacting with reagent ions. In contrast, highly polar analytes are ionised by thermal ionisation processes within the heated tube 3 and hence highly polar analyte ions pass into the reaction chamber 2. Analyte ions entering the reaction chamber 2 are substantially shielded from the effects of an electric field generated in the corona discharge chamber 1 as part of the process of generating reagent ions. The APCI ion source according to the preferred embodiment is able to optimally ionise a sample containing both low to moderately polar analytes and also highly polar analytes.
摘要翻译： 公开了一种大气压化学电离（“APCI”）离子源，其包括具有电晕放电室1，反应室2和将电晕放电室1连接到反应室2的通道6的壳体14。 在电晕放电室1中形成试剂离子，并通过通道6进入反应室2。 将分析物喷入加热管3中。 低至中等极性的分析物分子从加热管3进入反应室2，于是分析物分子通过与试剂离子相互作用而离子化。 相比之下，高极性分析物通过加热管3内的热离子化过程进行电离，因此高极性分析物离子进入反应室2。 作为产生试剂离子的过程的一部分，进入反应室2的分析物离子基本上不受电晕放电室1中产生的电场的影响的影响。 根据优选实施方案的APCI离子源能够最佳地离子化含有低至中等极性的分析物和高极性分析物的样品。
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