公开(公告)号：US11913059B1

公开(公告)日：2024-02-27

申请号：US17511033

申请日：2021-10-26

申请人： U.S. Army Combat Capabilities Development Command, Chemical Biological Center

发明人： Trevor G Glaros ,  Elizabeth S Dhummakupt ,  Phillip M Mach ,  Daniel O Carmany

IPC分类号： C12Q1/46 ,  H01J49/04 ,  H01J49/16 ,  G01N33/68

CPC分类号： C12Q1/46 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/168 ,  C12Y301/01007 ,  C12Y301/01008 ,  G01N2560/00

摘要： An apparatus and method for detecting an analyte of interest using paper spray mass spectrometry includes a spray material; a sample on the spray material including an enzyme of interest; a solvent to hydrate the sample, promote enzymatic activity, and extract analytes of interest from the sample; a substrate specific to the enzyme of interest, wherein any of the spray material and the solvent includes the substrate; a voltage source to apply a voltage to the spray material to create charged droplets of a mixture containing the sample; and a mass spectrometer to perform spectrometry on the droplets to perform any of: identify the analytes of interest in the sample; and measure a level of inhibition in any enzymes contained in the sample.

公开(公告)号：US20230329558A1

公开(公告)日：2023-10-19

申请号：US18083443

申请日：2022-12-16

申请人： Kresmir Franjic

发明人： Kresimir Franjic

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61K49/00 ,  A61K49/10 ,  G01R33/48 ,  G01R33/56 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC分类号： A61B5/0035 ,  A61B5/0075 ,  A61B5/055 ,  A61K49/0002 ,  A61K49/106 ,  G01R33/4808 ,  G01R33/5601 ,  H01J49/0463 ,  H01J49/168 ,  A61K49/103 ,  G01N30/72 ,  A61B2090/397

摘要： Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.

公开(公告)号：US11733247B2

公开(公告)日：2023-08-22

申请号：US16604933

申请日：2018-04-13

申请人： Micromass UK Limited

发明人： Stevan Bajic ,  Jeffery Mark Brown

IPC分类号： H01J49/10 ,  G01N33/68 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16 ,  H01J49/06 ,  H01J49/04

CPC分类号： G01N33/6857 ,  G01N30/7266 ,  G01N33/6848 ,  H01J49/0068 ,  H01J49/045 ,  H01J49/062 ,  H01J49/165 ,  H01J49/168

摘要： A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.

公开(公告)号：US20230215717A1

公开(公告)日：2023-07-06

申请号：US17998012

申请日：2021-05-05

申请人： Micromass UK Ltd

发明人： Arvind Rangan ,  Carl Chen ,  Steven Rocha ,  Enchen Guo ,  Nicola Lumley ,  David Douce ,  Richard Gallagher ,  Kate Whyatt

IPC分类号： H01J49/16 ,  H01J49/04

CPC分类号： H01J49/168 ,  H01J49/0404 ,  H01J49/0477 ,  H01J49/049

摘要： An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an aperture for receiving at least the distal end of a capillary into the ionisation chamber in use, the aperture having a capillary axis; a desolvation heater having a nozzle, for directing a stream of heated gas onto the distal end of the capillary in use, the nozzle having a nozzle axis; a corona discharge device including a corona pin having a corona axis, the corona pin for ionizing a sample in the ionisation chamber in use; and an inlet cone of a mass spectrometer arranged in the ionisation chamber, the inlet cone defining a cone entrance having a cone axis, wherein the cone axis is substantially coaxial with the corona axis and the capillary axis is substantially perpendicular to and intersects with the nozzle axis.

公开(公告)号：US20230194473A1

公开(公告)日：2023-06-22

申请号：US17927137

申请日：2021-05-27

申请人： SMITHS DETECTION-WATFORD LIMITED

发明人： Paul ARNOLD ,  Jonathan ATKINSON ,  Alastair CLARK ,  Elizabeth HUMPHREYS

IPC分类号： G01N27/622 ,  H01J49/16 ,  H01J49/06 ,  H01J49/04

CPC分类号： G01N27/622 ,  H01J49/061 ,  H01J49/168 ,  H01J49/0422

摘要： A method of operating an ion mobility spectrometer comprises the following steps: drawing a sample of gaseous fluid into a reaction region of the ion mobility spectrometer; providing a first pulse of a pulsed ionisation source to ionise the sample of gaseous fluid, thereby to obtain first sample ions; after a first gate delay following the first trigger opening an ion shutter to permit a portion of the first sample ions to leave the reaction region; providing a second pulse of the pulsed ionisation source to further ionise the sample of gaseous fluid, thereby to obtain second sample ions; after a second gate delay following the first trigger opening the ion shutter to permit a portion of the second sample ions to leave the reaction region, wherein the second gate delay is different from the first gate delay.

公开(公告)号：US20230178353A1

公开(公告)日：2023-06-08

申请号：US17998009

申请日：2021-05-05

申请人： Micromass UK Ltd

发明人： Nicola Lumley ,  David Douce ,  Gareth Rhys Jones

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/0477 ,  H01J49/0404 ,  H01J49/168

摘要： An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

公开(公告)号：US09443709B2

公开(公告)日：2016-09-13

申请号：US14355481

申请日：2012-11-16

申请人： Max Allsworth ,  Matthew Hart ,  John Somerville

发明人： Max Allsworth ,  Matthew Hart ,  John Somerville

IPC分类号： H01J49/16

CPC分类号： H01J49/168 ,  G01N27/624

摘要： A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.

摘要翻译： 将通过电晕放电产生的离子发射到待离子化的气流的电晕放电电离器装置包括具有引脚配置的尖端部分的放电电极。 提供了与放电电极间隔开距离的第二栅电极。 栅格电极优选由片状构造材料形成，该片材构造材料具有形成在其中的至少一个孔，其适于并构造成允许气体流过其中。 电源耦合到放电电极，配置的栅电极引起来自放电电极的离子发射。 电源优选地是交流电源，其被配置为产生紧邻放电电极的尖端部分的交变电场区域，足以使得在靠近放电电极的尖端部分流动的气体中引起雪崩击穿。

公开(公告)号：US20160163527A1

公开(公告)日：2016-06-09

申请号：US14909256

申请日：2013-08-02

申请人： SHIMADZU CORPORATION ,  PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY

发明人： Kanako SEKIMOTO ,  Mitsuo TAKAYAMA ,  Daisuke OKUMURA

IPC分类号： H01J49/16 ,  H01J49/26 ,  H01J49/14

CPC分类号： H01J49/167 ,  H01J49/142 ,  H01J49/145 ,  H01J49/168 ,  H01J49/26

摘要： In the ionizer of the present invention, a stream of gas spouted from a nozzle (18) of a DART ionization unit (10) vaporizes and ionizes the components in a sample (25). Gaseous sample-component molecules which have not been ionized by that process are subsequently ionized by a reaction with a reactant ion produced by a corona discharge generated from a needle electrode (20). Such a two-stage ionization of the sample-component molecules improves the ionization efficiency. A needle-electrode support mechanism (21) adjusts the position and/or angle of the needle electrode (20) and thereby controls a potential gradient. Therefore, a specific sample-derived ion species can be efficiently introduced into an ion introduction tube (31) and be detected with a high level of sensitivity.

摘要翻译： 在本发明的电离器中，从DART离子化单元（10）的喷嘴（18）喷出的气体气流使样品（25）中的组分汽化并电离。 随后通过与由针状电极（20）产生的电晕放电产生的反应物离子的反应使被该方法未被离子化的气态样品成分分子电离。 样品组分分子的这种两阶段电离提高了电离效率。 针状电极支撑机构（21）调整针状电极（20）的位置和/或角度，由此控制电位梯度。 因此，可以将特定的取样离子种类有效地引入离子导入管（31），并以高灵敏度检测。

公开(公告)号：US09337626B2

公开(公告)日：2016-05-10

申请号：US14577211

申请日：2014-12-19

申请人： Nuctech Company Limited

发明人： Qingjun Zhang ,  Yuanjing Li ,  Zhiqiang Chen ,  Yanchun Wang ,  Ziran Zhao ,  Yinong Liu ,  Yaohong Liu ,  Xiang Zou ,  Qiufeng Ma ,  Junxiao Wang ,  Xianghua Li ,  Jianping Chang

IPC分类号： H01J19/04 ,  H01T19/00 ,  G01N27/62 ,  H01J49/16

CPC分类号： H01T19/00 ,  G01N27/622 ,  H01J49/168

摘要： The present invention discloses a corona discharge assembly, an ion mobility spectrometer, an computer program and an computer readable storage medium. The corona discharge assembly includes: an ionization discharge chamber, wherein the ionization discharge chamber includes a metal corona cylinder, and the metal corona cylinder is provided with an inlet of a gas to be analyzed and a trumpet-shaped front port which is conductive to forming a gathered electric field; multiple corona pins, in which on-off of a high voltage can be independently controlled, are installed at the center of the metal corona cylinder in an insulating manner. The present invention further discloses an ion mobility spectrometer using the above-mentioned corona discharge assembly. The present invention can be used to prolong the service life of the integral corona discharge assembly; the discharge voltage of the ion source can be reduced and the discharge stability thereof can be improved; in comparison with the suspended installation of a pin-shaped electrode, since the multiple corona pins are fixed on the PCB, during installation, the position of the electrode can be accurate and stable, thus mass manufacture is easier to achieve.

摘要翻译： 本发明公开了电晕放电组件，离子迁移谱仪，计算机程序和计算机可读存储介质。 电晕放电组件包括：电离放电室，其中电离放电室包括金属电晕圆筒，并且金属电晕圆筒设置有要分析的气体的入口和导电以形成的喇叭形前端口 聚集的电场; 可以独立控制高电压开关的多个电晕针以绝缘方式安装在金属电晕圆筒的中心。 本发明还公开了使用上述电晕放电组件的离子迁移谱仪。 本发明可用于延长整个电晕放电组件的使用寿命; 可以降低离子源的放电电压，提高其放电稳定性; 与销状电极的悬挂安装相比，由于多个电晕针固定在PCB上，所以在安装过程中，电极的位置可以准确稳定，从而更容易实现批量制造。

公开(公告)号：US09231383B2

公开(公告)日：2016-01-05

申请号：US14578326

申请日：2014-12-19

申请人： NUCTECH COMPANY LIMITED

发明人： Qingjun Zhang ,  Yuanjing Li ,  Zhiqiang Chen ,  Yanchun Wang ,  Ziran Zhao ,  Yinong Liu ,  Yaohong Liu ,  Xiang Zou ,  Qiufeng Ma ,  Junxiao Wang ,  Jianping Chang

IPC分类号： H01J49/00 ,  H01T19/00 ,  H01J49/16 ,  G01N27/62

CPC分类号： H01T19/00 ,  G01N27/622 ,  H01J49/168

摘要： The present invention discloses a corona discharge assembly, including: an ionization discharge chamber, wherein the ionization discharge chamber includes a metal corona cylinder, and the metal corona cylinder is provided with an inlet of a gas to be analyzed and an annular piece-shaped port which forms a non-uniform electric field with corona pins and is provided with a circular hole at the middle; a rotating shaft is installed on the cylinder wall of the metal corona cylinder in an insulating manner, the rotating shaft is vertical to the axial line of the metal corona cylinder, and a turntable provided with multiple corona pins at the outer edge is installed at the end part of the rotating shaft the axial line of the metal corona cylinder passes in parallel through the rotation plane of the turntable. The present invention further discloses an ion mobility spectrometer using the above-mentioned corona discharge assembly.

摘要翻译： 本发明公开了一种电晕放电组件，包括：离子化放电室，其中电离放电室包括金属电晕圆筒，金属电晕圆筒设有待分析气体的入口和环形片状端口 其形成具有电晕针的不均匀电场，并在中间设置有圆形孔; 旋转轴以绝缘方式安装在金属电晕圆筒的气缸壁上，旋转轴垂直于金属电晕圆筒的轴线，并且在外边缘处设置有多个电晕针的转盘安装在 旋转轴的端部，金属电晕圆筒的轴线平行通过转台的旋转平面。 本发明还公开了使用上述电晕放电组件的离子迁移谱仪。