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135 条记录 (耗时 0.045 秒)

    Accelerometer-based heart sound detection for autocapture
    81.
    发明授权
    Accelerometer-based heart sound detection for autocapture 有权
    基于加速度计的心脏声音检测

    公开(公告)号：US06650940B1

    公开(公告)日：2003-11-18

    申请号：US09496832

    申请日：2000-02-02

    申请人： Qingsheng Zhu ,  Julio C. Spinelli ,  Gerrard M. Carlson

    发明人： Qingsheng Zhu ,  Julio C. Spinelli ,  Gerrard M. Carlson

    IPC分类号： A61N1365

    CPC分类号： A61N1/36542 ,  A61N1/3712

    摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.

    摘要翻译： 一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。 该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。 加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。 设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。 此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

    Heart rate variability as an indicator of exercise capacity
    82.
    发明授权
    Heart rate variability as an indicator of exercise capacity 失效
    心率变异性作为运动能力的指标

    公开(公告)号：US6026320A

    公开(公告)日：2000-02-15

    申请号：US93118

    申请日：1998-06-08

    申请人： Gerrard M. Carlson ,  Veerichetty A. Kadhiresan ,  Julio C. Spinelli

    发明人： Gerrard M. Carlson ,  Veerichetty A. Kadhiresan ,  Julio C. Spinelli

    IPC分类号： A61B5/0456 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/365 ,  A61N1/3627 ,  A61N1/36592

    摘要： Based upon patient studies indices a high degree of correlation was found between HRV and VO2.sub.max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy.

    摘要翻译： 根据患者研究指标，发现HRV和VO2max之间存在高度相关性，即患者的运动能力。 基于这一发现，已经设计了用于治疗CHF患者的起搏治疗优化方案。 该方案涉及首先用编程为在第一模式中操作预定时间段的起搏器起搏患者的心脏，然后收集从其导出HRV指数的电描记图数据。 然后改变模式，重复步骤直到所有可能的模式被使用。 此时，确定哪个模式与最大HRV指数相关联，并且起搏器然后被编程为在该模式下起作用。 或者，本发明的方法可以应用于药物治疗的变化，而不是起搏治疗或与起搏治疗组合。

    MAXIMUM PACING RATE LIMITER SYSTEM
    85.
    发明申请
    MAXIMUM PACING RATE LIMITER SYSTEM 失效
    最大速率限制系统

    公开(公告)号：US20110230926A1

    公开(公告)日：2011-09-22

    申请号：US13115825

    申请日：2011-05-25

    申请人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio C. Spinelli

    发明人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio C. Spinelli

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365

    摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.

    摘要翻译： 与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。 最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。 最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。 在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率 到起搏器。

    Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds
    86.
    发明授权
    Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds 有权
    使用心脏声音优化心脏再同步治疗的方法和装置

    公开(公告)号：US07953484B2

    公开(公告)日：2011-05-31

    申请号：US11687812

    申请日：2007-03-19

    申请人： Marina Brockway ,  William C. Lincoln ,  Gerrard M. Carlson

    发明人： Marina Brockway ,  William C. Lincoln ,  Gerrard M. Carlson

    IPC分类号： A61N1/00

    CPC分类号： A61B5/0538 ,  A61B5/0809 ,  A61B5/113 ,  A61B5/7203 ,  A61B5/726 ,  A61B7/00 ,  A61N1/36514 ,  G06K9/00496

    摘要： A cardiac rhythm management system provides for assessment of cardiac mechanical dyssynchrony based on heart sound morphology and optimization of pacing parameters based on the effect of pacing on the cardiac mechanical dyssynchrony assessment. A degree of cardiac mechanical dyssynchrony is measured by the time delay between tricuspid valve closure and mitral valve closure and/or the time delay between pulmonary valve closure and aortic valve closure. A cardiac resynchronization therapy is optimized by determining therapy parameters to provide an approximately minimum degree of cardiac mechanical dyssynchrony by cardiac pacing.

    摘要翻译： 心脏节律管理系统基于心脏机械不同步评估的起搏效果，提供基于心脏声音形态和起搏参数优化的心脏机械不同步的评估。 通过三尖瓣关闭和二尖瓣关闭之间的时间延迟和/或肺动脉瓣关闭与主动脉瓣闭合之间的时间延迟来测量心脏机械不同步程度。 通过确定治疗参数来优化心脏再同步治疗，以通过心脏起搏提供心脏机械不同步的近似程度。

    System and method for monitoring autonomic balance and physical activity
    87.
    发明授权
    System and method for monitoring autonomic balance and physical activity 有权
    监测自主性平衡和身体活动的系统和方法

    公开(公告)号：US07833164B2

    公开(公告)日：2010-11-16

    申请号：US12538553

    申请日：2009-08-10

    申请人： Avram Scheiner ,  Donald L. Hopper ,  Gerrard M. Carlson

    发明人： Avram Scheiner ,  Donald L. Hopper ,  Gerrard M. Carlson

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

    摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

    摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

    HEMODYNAMIC STABILITY ASSESSMENT BASED ON HEART SOUNDS
    88.
    发明申请
    HEMODYNAMIC STABILITY ASSESSMENT BASED ON HEART SOUNDS 有权
    基于心脏声音的动态稳定性评估

    公开(公告)号：US20100249863A1

    公开(公告)日：2010-09-30

    申请号：US12813073

    申请日：2010-06-10

    申请人： Gerrard M. Carlson ,  Yayun Lin

    发明人： Gerrard M. Carlson ,  Yayun Lin

    IPC分类号： A61N1/365 ,  A61B5/02

    CPC分类号： A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

    摘要： A method comprises detecting at least one episode of ventricular tachyarrhythmia in a subject using an implantable medical device (IMD), sensing at least one heart sound signal for the subject using the IMD, the heart sound signal associated with mechanical vibration of a heart of the subject; initiating, in response to and during the detected episode of tachyarrhythmia, a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal, and deeming whether the ventricular tachyarrhythmia is stable according to the measurement of hemodynamic stability. The measurement of hemodynamic stability is determined using linear prediction.

    摘要翻译： 一种方法包括使用可植入医疗装置（IMD）检测受试者中的至少一次心室快速性心律失常，使用IMD感测对象的至少一个心音信号，与心脏的心脏的机械振动相关的心音信号 学科; 响应于和在检测到的快速性心律失常发作期间，从心脏声音信号测量心室快速性心律失常的血液动力学稳定性，并且根据血液动力学稳定性的测量来确定心室性心律失常是否稳定。 使用线性预测确定血液动力学稳定性的测量。

    System and method for monitoring autonomic balance and physical activity
    90.
    发明授权
    System and method for monitoring autonomic balance and physical activity 有权
    监测自主性平衡和身体活动的系统和方法

    公开(公告)号：US07572226B2

    公开(公告)日：2009-08-11

    申请号：US10695430

    申请日：2003-10-28

    申请人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    发明人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

    摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

    摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。