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公开(公告)号：US10561765B2
公开(公告)日：2020-02-18
申请号：US15746574
申请日：2016-07-22
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US20180263631A1
公开(公告)日：2018-09-20
申请号：US15984003
申请日：2018-05-18
Inventor： Thomas S. Wilson , Ward Small, IV , William J. Benett , Jason M. Ortega , Duncan J. Maitland , Jonathan Hartman
CPC classification number: A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12181 , A61B2017/00871 , A61B2017/12054 , A61M25/0668 , A61M2025/0042
Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
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Patent Agency Ranking
公开(公告)号：US20180208735A1
公开(公告)日：2018-07-26
申请号：US15746471
申请日：2016-07-22
Inventor： Landon D. Nash , Duncan J. Maitland , Nicole Docherty , Thomas S. Wilson , Ward Small, IV , Jason Ortega , Pooja Singhal
Abstract: An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
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公开(公告)号：US20140296358A1
公开(公告)日：2014-10-02
申请号：US14307691
申请日：2014-06-18
Inventor： Duncan J. Maitland , Thomas S. Wilson
CPC classification number: A61L27/18 , A61L27/56 , A61L2400/16 , A61L2430/36 , C08L75/04
Abstract: Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms.
Abstract translation: 植入装置和结构，减少炎症和促进植入物区域的愈合。 具体地，使用形状记忆开放细胞生物相容性聚合物泡沫用于有助于和促进愈合，特别是填充和密封动脉瘤的植入物。
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85.发明申请ULTRA LOW DENSITY BIODEGRADABLE SHAPE MEMORY POLYMER FOAMS WITH TUNABLE PHYSICAL PROPERTIES 审中-公开超低密度可生物降解形状记忆聚合物具有可调物理特性公开(公告)号：US20140142207A1
公开(公告)日：2014-05-22
申请号：US13797631
申请日：2013-03-12
Inventor： Pooja Singhal , Thomas S. Wilson , Elizabeth Cosgriff-Hernandez , Duncan J. Maitland
IPC: C08G71/04 , C08G63/00 , C08J9/00 , C08G63/685
CPC classification number: C08G18/6622 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , C08G18/10 , C08G18/14 , C08G18/165 , C08G18/73 , C08G63/00 , C08G63/6852 , C08G71/04 , C08G2101/005 , C08G2101/0083 , C08G2230/00 , C08G2280/00 , C08J9/00 , C08J2375/06
Abstract: Compositions and/or structures of degradable shape memory polymers (SMPs) ranging in form from neat/unfoamed to ultra low density materials of down to 0.005 g/cc density. These materials show controllable degradation rate, actuation temperature and breadth of transitions along with high modulus and excellent shape memory behavior. A method of making extremely low density foams (up to 0.005 g/cc) via use of combined chemical and physical blowing agents, where the physical blowing agents may be a single compound or mixtures of two or more compounds, and other related methods, including of using multiple co-blowing agents of successively higher boiling points in order to achieve a large range of densities for a fixed net chemical composition. Methods of optimization of the physical properties of the foams such as porosity, cell size and distribution, cell openness etc. of these materials, to further expand their uses and improve their performance.
Abstract translation: 范围从纯/未发泡到超低密度材料形式的可降解形状记忆聚合物（SMP）的组合物和/或结构，其浓度低至0.005g / cc。 这些材料显示可控的降解速率，致动温度和转变幅度以及高模量和优异的形状记忆行为。 通过使用组合的化学和物理发泡剂制造极低密度泡沫（高达0.005g / cc）的方法，其中物理发泡剂可以是单一化合物或两种或更多种化合物的混合物，以及其它相关方法，包括 使用多个连续较高沸点的共发泡剂，以实现固定净化学成分的大范围密度。 优化泡沫物理性能的方法，如孔隙度，孔径，分布，细胞开放度等，进一步扩大使用范围，提高其性能。
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86.发明申请公开(公告)号：US20130317541A1
公开(公告)日：2013-11-28
申请号：US13797727
申请日：2013-03-12
Inventor： Pooja Singhal , Thomas S. Wilson , Elizabeth Cosgriff-Hernandez , Duncan J. Maitland
IPC: A61B17/00
CPC classification number: C08G18/6622 , A61B17/0057 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , C08G18/10 , C08G18/14 , C08G18/165 , C08G18/73 , C08G63/00 , C08G63/6852 , C08G71/04 , C08G2101/005 , C08G2101/0083 , C08G2230/00 , C08G2280/00 , C08J9/00 , C08J2375/06
Abstract: A device, system and method for treatment of an opening in vascular and/or septal walls including patent foramen ovale. The device has wings/stops on either end, an axis core covered in a shape memory foam and is deliverable via a catheter to the affected opening, finally expanding into a vascular or septal opening where it is held in place by the expandable shape memory stops or wings.
Abstract translation: 用于治疗血管和/或间隔壁中的开口的装置，系统和方法，包括卵孔卵孔。 该装置在任一端具有翼/止动件，轴芯覆盖在形状记忆泡沫中，并且可通过导管输送到受影响的开口，最后扩展成血管或间隔开口，其中可扩张形状记忆停止 或翅膀。
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公开(公告)号：US20130089576A1
公开(公告)日：2013-04-11
申请号：US13633388
申请日：2012-10-02
Inventor： Duncan J. Maitland , Thomas S. Wilson
CPC classification number: A61L27/18 , A61L27/56 , A61L2400/16 , A61L2430/36 , C08L75/04
Abstract: Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms.
Abstract translation: 植入装置和结构，减少炎症和促进植入物区域的愈合。 具体地，使用形状记忆开放细胞生物相容性聚合物泡沫用于有助于和促进愈合，特别是填充和密封动脉瘤的植入物。
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