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    System and method for monitoring patient condition using atrial timing characteristics
    81.
    发明授权
    System and method for monitoring patient condition using atrial timing characteristics 有权
    使用心房定时特征监测患者状况的系统和方法

    公开(公告)号：US09533158B2

    公开(公告)日：2017-01-03

    申请号：US12333176

    申请日：2008-12-11

    申请人： Xiaoyi Min

    发明人： Xiaoyi Min

    IPC分类号： A61N1/00 ,  A61N1/37 ,  A61B5/0452 ,  A61N1/368 ,  A61N1/362

    CPC分类号： A61N1/37 ,  A61B5/0452 ,  A61N1/3627 ,  A61N1/368

    摘要： A system and method for using an implantable cardiac stimulation device to monitor a patient for the progress of an existing condition and/or early detection of an emerging condition based, at least in part, on measuring and evaluating the timing characteristics of the patient's atrial activity. The atrial timing characteristics are used as indicators or predictors of conditions of interest, such as heart failure (HF) and atrial fibrillation (AF). In certain implementations, the system can determine discriminating indicators of a predominant underlying cause of a condition, such as between vagal and non-vagal AF, as an indicator of a suggested therapy. The system can store data corresponding to the observed atrial timing for trending analysis as well as transmit data for offline analysis, such as via an external device.

    摘要翻译： 一种系统和方法，用于至少部分地基于测量和评估患者心房活动的时间特征来使用可植入心脏刺激装置来监测患者现有病症的进展和/或新出现的病症的早期检测 。 心房时间特征被用作心脏衰竭（HF）和房颤（AF）等感兴趣条件的指标或预测指标。 在某些实施方案中，系统可以确定病症的主要潜在原因（例如迷走神经与非迷走神经AF之间）的鉴别指标，作为建议治疗的指标。 系统可以存储对应于观察到的心房定时的数据，用于趋势分析，以及用于离线分析的传输数据，例如通过外部设备。

    Optimal pacing configuration via ventricular conduction delays
    82.
    发明授权
    Optimal pacing configuration via ventricular conduction delays 有权
    通过心室传导延迟的最佳起搏配置

    公开(公告)号：US09381363B2

    公开(公告)日：2016-07-05

    申请号：US12632519

    申请日：2009-12-07

    申请人： Kyungmoo Ryu ,  Xiaoyi Min

    发明人： Kyungmoo Ryu ,  Xiaoyi Min

    IPC分类号： A61N1/36 ,  A61N1/37 ,  A61N1/368 ,  A61N1/362 ,  A61N1/372

    CPC分类号： A61N1/3684 ,  A61N1/056 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371 ,  A61N1/37247

    摘要： An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle; selecting a ventricular electrode from the series; delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response; acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series; based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities; based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy; and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.

    摘要翻译： 用于优化起搏配置的示例性方法包括提供与心室相关联的一系列三个或更多个心室电极的电极之间的距离; 从该系列中选择一个心室电极; 通过选择的心室电极向心室输送能量，足以引起诱发反应的能量; 通过该系列的非选择性心室电极获取与诱发反应相关的心脏电活动的信号; 基于通过未选择的心室电极获取的心脏电活动的信号和距离，确定传导速度; 基于传导速度，确定所选择的心室电极是否是用于递送心脏起搏疗法的最佳电极; 并且如果所选择的心室电极包括用于递送心脏起搏治疗的最佳电极，则要求使用所选择的心室电极递送心脏起搏治疗。 还公开了各种其它方法，装置，系统等。

    Initiation tests and guidelines for implementing cardiac therapy
    83.
    发明授权
    Initiation tests and guidelines for implementing cardiac therapy 有权
    启动心脏治疗的测试和指南

    公开(公告)号：US09314634B2

    公开(公告)日：2016-04-19

    申请号：US12264077

    申请日：2008-11-03

    申请人： Xiaoyi Min

    发明人： Xiaoyi Min

    IPC分类号： A61N1/362 ,  A61N1/372

    CPC分类号： A61N1/3627 ,  A61N1/37247

    摘要： An exemplary system includes a programmer configured to instruct an implantable device and a qualification module with instructions to call for tests performed by an implantable device configured for delivery of CRT, to receive results from the tests, to analyze the results and to decide, based on the analysis, if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters and, only if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters, presenting a graphical user interface that comprises a selectable control to enable an algorithm of an implantable device to automatically optimize at least one of the one or more cardiac resynchronization therapy parameters. Other exemplary methods, devices, systems, etc., are also disclosed.

    摘要翻译： 示例性系统包括编程器，其被配置为指示可植入装置和鉴定模块，其具有用于调用由配置用于输送CRT的可植入装置执行的测试的指令，以接收来自测试的结果，以分析结果并基于 如果患者符合一个或多个CRT参数的自动植入式设备优化，并且仅当患者符合对一个或多个CRT参数进行自动可植入设备的优化时，呈现图形用户界面，该图形用户界面包括 可选择的控制以使可植入装置的算法能够自动优化所述一个或多个心脏再同步治疗参数中的至少一个。 还公开了其它示例性方法，装置，系统等。

    Multi-piece dual-chamber leadless intra-cardiac medical device and method of implanting same
    85.
    发明授权
    Multi-piece dual-chamber leadless intra-cardiac medical device and method of implanting same 有权
    多片双室无引线心脏内心脏医疗器械及其植入方法

    公开(公告)号：US09017341B2

    公开(公告)日：2015-04-28

    申请号：US13352005

    申请日：2012-01-17

    申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

    发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

    IPC分类号： A61B19/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/372 ,  A61N1/365

    CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/36521 ,  A61N1/37288 ,  A61N1/3756

    摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

    摘要翻译： 无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。 电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。 该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。 壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。 该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

    Leadless intra-cardiac medical device with reduced number of feed-thrus
    86.
    发明授权
    Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
    无铅心脏内心脏医疗器械，饲料数量减少

    公开(公告)号：US09008777B2

    公开(公告)日：2015-04-14

    申请号：US13529226

    申请日：2012-06-21

    申请人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

    发明人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

    IPC分类号： A61N1/00 ,  A61N1/375 ,  A61N1/368

    CPC分类号： A61N1/3756 ,  A61B5/042 ,  A61N1/362 ,  A61N1/368 ,  Y10T29/49002

    摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

    摘要翻译： 无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。 端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。 非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。 第一电极从端盖的近端突出。 心脏内（IC）装置延伸部从电池盒的远端伸出。 该延伸部包括电连接到电池壳体的第二电极。 第二电极远离LIMD远端。 电子模块位于端盖的内部空腔内并与第一和第二电极连通。

    Posture detection using pressure and other physiologic sensors
    87.
    发明授权
    Posture detection using pressure and other physiologic sensors 有权
    使用压力和其他生理传感器的姿势检测

    公开(公告)号：US08731665B1

    公开(公告)日：2014-05-20

    申请号：US11923286

    申请日：2007-10-24

    申请人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

    发明人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

    IPC分类号： A61N1/00

    CPC分类号： A61N1/365 ,  A61N1/36535

    摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.

    摘要翻译： 提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。 在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

    Method and system for discrimination of VT and SVT arrhythmias
    89.
    发明授权
    Method and system for discrimination of VT and SVT arrhythmias 有权
    用于鉴别VT和SVT心律失常的方法和系统

    公开(公告)号：US08670825B2

    公开(公告)日：2014-03-11

    申请号：US13563311

    申请日：2012-07-31

    申请人： Xiaoyi Min ,  Eliot L. Ostrow

    发明人： Xiaoyi Min ,  Eliot L. Ostrow

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3621 ,  A61B5/04012 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/395 ,  A61N1/3962

    摘要： Methods and systems are provided for discriminating heart arrhythmias. The methods and systems include identifying an arrhythmia, recording a predetermined number of beats during the arrhythmia as a base arrhythmia (BA) beats; delivering anti-tachy pacing (ATP) therapy to at least one chamber of the heart. After delivering the ATP therapy, the methods and system record at least one return beat representing cardiac activity following the ATP therapy, determines whether the return beat originated in a reference chamber of the heart, compares a morphology of the return beat to a morphology of the BA beat; and declares a VT or SVT based on the comparing operation.

    摘要翻译： 提供方法和系统用于区分心律失常。 方法和系统包括鉴定心律失常，在心律失常期间记录预定数量的搏动作为基础心律失常（BA）; 向心脏至少一个室提供抗速度起搏（ATP）治疗。 在ATP疗法交付之后，方法和系统记录在ATP治疗后代表心脏活动的至少一个返回搏动，确定起搏于心脏的参考室的返回搏动是否将返回搏动的形态与 BA打败 并根据比较操作声明VT或SVT。