公开(公告)号：US20220233541A1

公开(公告)日：2022-07-28

申请号：US17586777

申请日：2022-01-27

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Charles Kung ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14

摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.

公开(公告)号：US20210386749A1

公开(公告)日：2021-12-16

申请号：US17133994

申请日：2020-12-24

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta

IPC分类号： A61K31/53 ,  A61K31/136 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61P35/02

摘要： Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.

公开(公告)号：US20210198234A1

公开(公告)日：2021-07-01

申请号：US16760520

申请日：2018-11-02

申请人： AGIOS PHARMACEUTICALS, INC.

发明人： Benjamin S. LANE ,  Chong-Hui GU

IPC分类号： C07D401/04 ,  A61K45/06

摘要： Provided are solid forms of a compound useful for treating cancer, pharmaceutical compositions thereof, and methods of treating cancer comprising administering the solid forms described herein to a patient in need thereof.

公开(公告)号：US11021515B2

公开(公告)日：2021-06-01

申请号：US16871777

申请日：2020-05-11

申请人： Agios Pharmaceuticals, Inc.

发明人： Rene M. Lemieux ,  Janeta Popovici-Muller ,  Jeremy Travins ,  Zhenwei Cai ,  Dawei Cui ,  Ding Zhou

IPC分类号： C07K5/06 ,  A61K38/07 ,  A61K45/06 ,  A61K38/05 ,  A61K38/00

摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

公开(公告)号：US20210155603A1

公开(公告)日：2021-05-27

申请号：US16915936

申请日：2020-06-29

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K9/20 ,  A61K31/53 ,  A61P35/00 ,  A61K31/444

摘要： Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

公开(公告)号：US10988448B2

公开(公告)日：2021-04-27

申请号：US16243247

申请日：2019-01-09

申请人： Agios Pharmaceuticals, Inc.

发明人： Francesco G. Salituro ,  Jeffrey O. Saunders ,  Shunqi Yan

IPC分类号： A61K31/397 ,  C07D229/00 ,  C07D403/12 ,  C07D215/36 ,  A61K31/497 ,  A61K31/5513 ,  C07D215/40 ,  C07D239/42 ,  C07D241/20 ,  C07D243/08 ,  C07D271/12 ,  C07D277/64 ,  C07D277/68 ,  C07D319/18 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D295/192

摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

公开(公告)号：US20210088520A1

公开(公告)日：2021-03-25

申请号：US17009126

申请日：2020-09-01

申请人： Agios Pharmaceuticals, Inc.

发明人： Yaguang Si ,  Marie C. Keenan

IPC分类号： G01N33/574 ,  A61K31/47 ,  A61K31/519 ,  C12Q1/6886 ,  A61K31/42 ,  A61K31/167 ,  A61K31/44 ,  A61K31/381 ,  A61K31/4418 ,  A61K31/341 ,  A61K31/277 ,  A61P35/00

摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with a DHODH inhibitor or an antimetabolite. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by a DHODH inhibitor or an antimetabolite, comprising assessing whether the tumor cell comprises a mutant IDH gene or protein whereby cells that comprise a mutant IDH gene or protein are sensitive to inhibition by DHODH inhibitors and antimetabolites.

公开(公告)号：US20210077490A1

公开(公告)日：2021-03-18

申请号：US16952257

申请日：2020-11-19

申请人： Agios Pharmaceuticals, Inc.

发明人： Giovanni Cianchetta ,  Tao Liu ,  Anil Kumar Padyana ,  Zhihua Sui ,  Zhenwei Cai ,  Dawei Cui ,  Jingjing Ji

IPC分类号： A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  C07D241/36 ,  C07D513/14

摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

公开(公告)号：US20210046081A1

公开(公告)日：2021-02-18

申请号：US17001741

申请日：2020-08-25

申请人： Agios Pharmaceuticals, Inc.

发明人： Joshua Murtie ,  Nelamangala Nagaraja ,  Brandon Nicolay ,  David Schenkein ,  Katharine Yen

IPC分类号： A61K31/53 ,  A61P35/00

摘要： Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.

公开(公告)号：US20210024575A1

公开(公告)日：2021-01-28

申请号：US16893750

申请日：2020-06-05

申请人： Agios Pharmaceuticals, Inc.

发明人： Janeta Popovici-Muller ,  Rene M. Lemieux ,  Jeremy Travins ,  Zhenwei Cai ,  Dawei Cui ,  Ding Zhou

IPC分类号： C07K5/065 ,  C07D207/26 ,  C07D205/08 ,  C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  A61K38/05 ,  A61K45/06 ,  A61K38/00

摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.