公开(公告)号：US11708332B2

公开(公告)日：2023-07-25

申请号：US17526377

申请日：2021-11-15

Applicant: BioCryst Pharmaceuticals, Inc.

Inventor： Pravin L. Kotian ,  Yarlagadda S. Babu ,  Minwan Wu ,  Venkat R. Chintareddy ,  V. Satish Kumar ,  Weihe Zhang

IPC: C07D231/14 ,  C07D403/12 ,  C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D231/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed are compounds of formula I






as described herein, and pharmaceutically acceptable salts thereof. The compounds are disclosed to be inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

公开(公告)号：US20230219890A1

公开(公告)日：2023-07-13

申请号：US18009362

申请日：2021-06-10

Applicant: Betta Pharmaceuticals Co.,Ltd

Inventor： Rongwen YANG ,  Yun SUN ,  Jian ZHANG ,  Xiangkai LIU ,  Pingping WANG ,  Xuegang YI ,  Teng MA ,  Chuanlong HUANG ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC: C07D209/30 ,  C07D209/10 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D417/04 ,  C07D209/08 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

CPC classification number: C07D209/30 ,  C07D209/10 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D417/04 ,  C07D209/08 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

Abstract: The present invention relates to a compound as represented by formula (I). The present invention also provides compositions and formulations containing such compounds, and methods for using and preparing such compounds.

公开(公告)号：US11695157B2

公开(公告)日：2023-07-04

申请号：US17583240

申请日：2022-01-25

Applicant: Contemporary Amperex Technology Co., Limited

Inventor： Tiancheng Yi ,  Chunhua Hu ,  Shushi Dou ,  Yao Jiang ,  Chengdu Liang

IPC: H01M10/0567 ,  C01G51/00 ,  C07D239/04 ,  C07D241/04 ,  C07D251/04 ,  C07D295/145 ,  C07D403/04 ,  H01M4/525 ,  H01M10/0525 ,  H01M10/42 ,  H01M10/0568 ,  H01M4/02

CPC classification number: H01M10/0567 ,  C01G51/006 ,  C01G51/42 ,  C07D239/04 ,  C07D241/04 ,  C07D251/04 ,  C07D295/145 ,  C07D403/04 ,  H01M4/525 ,  H01M10/0525 ,  H01M10/0568 ,  H01M10/4235 ,  C01P2002/52 ,  C01P2006/40 ,  H01M2004/028 ,  H01M2300/0025

Abstract: This application provides a lithium-ion battery and an apparatus. The lithium-ion battery includes an electrode assembly and an electrolyte. The electrode assembly includes a positive electrode plate, a negative electrode plate, and a separator. A positive active material of the positive electrode plate includes Lix1Coy1M1-y1O2-z1Qz1, where 0.5≤x1≤1.2, 0.8≤y1≤1.0, 0≤z1≤0.1, M is selected from one or more of Al, Ti, Zr, Y, and Mg, and Q is selected from one or more of F, Cl, and S. The electrolyte contains an additive A that is a polynitrile six-membered nitrogen-heterocyclic compound with a relatively low oxidation potential. The lithium-ion battery has superb cycle performance and storage performance, especially under high-temperature and high-voltage conditions.

公开(公告)号：US20230203007A1

公开(公告)日：2023-06-29

申请号：US17951644

申请日：2022-09-23

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Verner Alexander Lofstrand ,  Jung Yun Kim ,  Helen Clement ,  Kristen Nicole Burford ,  Paul Charifson ,  Shawn Johnstone ,  Juliette Sabbatani ,  Jan Felix Scholtes ,  Wei Zhang ,  Shaoyi Sun ,  Michael Clark ,  Steve Wesolowski ,  Ravi Munuganti ,  Ramkumar Rajamani

IPC: C07D401/14 ,  C07D401/04 ,  C07D487/04 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D213/82 ,  C07D213/74 ,  C07D491/107 ,  C07D498/08 ,  C07D471/10 ,  C07D471/08 ,  C07D487/10 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04 ,  C07D471/14 ,  C07F7/08

CPC classification number: C07D401/14 ,  C07D213/74 ,  C07D213/82 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D471/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/08 ,  C07F7/0812

Abstract: The present disclosure is directed to compounds of formula (I):





wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20230192627A1

公开(公告)日：2023-06-22

申请号：US18010241

申请日：2021-04-02

Applicant: Shaanxi Lighte Optoelectronics Material Co., Ltd.

Inventor： Kongyan ZHANG ,  Tiantian MA ,  Jiamei CAO

IPC: C07D239/26 ,  H10K50/16 ,  H10K30/85 ,  H10K85/60 ,  C07D251/24 ,  C07D405/04 ,  C07D405/14 ,  C07D405/10 ,  C07D401/04 ,  C07D409/04 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D409/10 ,  C07D401/10 ,  C07D403/10 ,  C07D491/048

CPC classification number: C07D239/26 ,  H10K50/16 ,  H10K30/85 ,  H10K85/654 ,  H10K85/652 ,  C07D251/24 ,  C07D405/04 ,  H10K85/6574 ,  C07D405/14 ,  C07D405/10 ,  C07D401/04 ,  C07D409/04 ,  H10K85/6576 ,  H10K85/621 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D409/10 ,  C07D401/10 ,  C07D403/10 ,  C07D491/048 ,  H10K85/657 ,  H10K85/6572 ,  C07B2200/05

Abstract: The present disclosure provides a nitrogen-containing compound, an electronic element, and an electronic device, and belongs to the technical field of organic materials. In the nitrogen-containing compound, 1-adamantyl and a cyano group are connected on a nitrogen-containing heteroaryl core structure by a linking group, so that the molecule has a high dipole moment as a whole, organic materials with a high electron mobility can be obtained, and the electron transport properties of the electronic element can be improved, and when the nitrogen-containing compound is used as an electron transport layer of an organic electroluminescent device, the luminous efficiency and service life of the device can be improved, and the operating voltage can be reduced.

公开(公告)号：USRE49556E1

公开(公告)日：2023-06-20

申请号：US17376199

申请日：2021-07-15

Applicant: Array BioPharma Inc.

Inventor： Shenlin Huang ,  Xianming Jin ,  Zuosheng Liu ,  Daniel Poon ,  John Tellew ,  Yongqin Wan ,  Xing Wang ,  Yongping Xie

IPC: A61K31/506 ,  A61K9/00 ,  A61K31/4184 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14

CPC classification number: A61K31/506 ,  A61K9/0053 ,  A61K31/4184 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61K31/506 ,  A61K2300/00

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

公开(公告)号：US11680053B2

公开(公告)日：2023-06-20

申请号：US17519486

申请日：2021-11-04

Applicant: Heptares Therapeutics Limited

Inventor： John Andrew Christopher ,  Miles Stuart Congreve ,  Sarah Joanne Aves ,  Benjamin Gerald Tehan

IPC: C07D401/04 ,  C07D403/04 ,  C07D239/26

CPC classification number: C07D401/04 ,  C07D239/26 ,  C07D403/04

Abstract: The disclosures herein relate to novel compounds of formula




wherein R1, R2, R3 and R4 and n are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of inflammation, neurological or psychiatric disorders associated with modulating mGlu5 receptor function.

公开(公告)号：US20230183191A1

公开(公告)日：2023-06-15

申请号：US18011696

申请日：2021-08-06

Applicant: Shaanxi Lighte Optoelectronics Material Co., Ltd.

Inventor： Lingang LI ,  Tiantian MA ,  Lei YANG

IPC: C07D251/24 ,  H10K85/60 ,  C07D409/04 ,  C07D403/04 ,  C07D213/57 ,  C07D401/04 ,  C07D401/10 ,  C07F7/08 ,  H10K85/40 ,  C07D409/10 ,  C07D405/10 ,  C07D239/26 ,  C07D405/04 ,  H10K50/16

CPC classification number: C07D251/24 ,  H10K85/654 ,  H10K85/652 ,  C07D409/04 ,  H10K85/6576 ,  C07D403/04 ,  H10K85/6572 ,  C07D213/57 ,  C07D401/04 ,  C07D401/10 ,  C07F7/0812 ,  H10K85/40 ,  C07D409/10 ,  H10K85/6574 ,  C07D405/10 ,  C07D239/26 ,  C07D405/04 ,  H10K50/16 ,  C07B2200/05

Abstract: The present disclosure belongs to the field of organic light-emitting materials, and provides a nitrogen-containing compound, an electronic element and an electronic device. The structure of the nitrogen-containing compound is shown as Formula 1, wherein X1, X2 and X3 are each independently selected from C(H) or N, and at least one of the three is selected from N; and Ar1 and Ar2 are each independently selected from a substituted or unsubstituted aryl with 6 to 40 carbon atoms. The nitrogen-containing compound can improve performance of the electronic element.

公开(公告)号：US20230180754A1

公开(公告)日：2023-06-15

申请号：US17924256

申请日：2021-05-03

Applicant: BASF SE

Inventor： Nikolas Huwyler ,  Arun Narine ,  Karsten Koerber ,  Erik Gilberg ,  Joachim Dickhaut ,  Jan Klaas Lohmann

IPC: A01N43/653 ,  A01P7/04 ,  C07D403/04 ,  C07D413/14 ,  A01N43/80 ,  C07D498/04 ,  A01N43/90 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: A01N43/653 ,  A01P7/04 ,  C07D403/04 ,  C07D413/14 ,  A01N43/80 ,  C07D498/04 ,  A01N43/90 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

公开(公告)号：US11667624B2

公开(公告)日：2023-06-06

申请号：US17380736

申请日：2021-07-20

Applicant: NIDO BIOSCIENCES, INC.

Inventor： Bakary-Barry Toure ,  Mark Andrew Gallop ,  Paul Andrew Barsanti

IPC: C07D403/14 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  C07D403/04

CPC classification number: C07D403/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D471/04

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.