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    N-(2,2-diloweralkoxyalkyl)-2,2-dilower-alkoxyloweralkanamidines and their acid addition salts
    81.
    发明授权
    N-(2,2-diloweralkoxyalkyl)-2,2-dilower-alkoxyloweralkanamidines and their acid addition salts 失效
    N-（2,2-二氧代烷基甲基）-2,2-二氧化铝 - 碱金属胺及其酸添加物

    公开(公告)号：US3812189A

    公开(公告)日：1974-05-21

    申请号：US27456072

    申请日：1972-07-24

    Applicant: AMERICAN CYANAMID CO

    Inventor： ENGLISH J ,  BERKELHAMMER G

    IPC: C07D233/54 ,  C07D233/64 ,  C07C123/00

    CPC classification number: C07D233/64

    Abstract: THE COMPOUNDS N - (2,2-DILOWERALKOXYALKYL)-2,2-DILOWERALKOXYLOWERALKANAMIDINES, THE ACID ADDITION SALTS THEREOF AND A METHOD FOR THEIR PREPARATION, ARE DESCRIBED. A PROCESS FOR THE PREPARATION OF IMIDAZOLE-2-CARBOXALDEHYDE AND 2-IMIDAZOLYALKYL KETONES UTILIZING THE ABOVE DESCRIBED COMPOUNDS AS INTERMEDIATES ARE ALSO DESCRIBED. THE LATTER COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE PREPARATION OF 2-AMINO-5-(2-IMIDAZOLYL)-1,3,4-THIADIAZOLES, WHICH ARE HIGHLY EFFECTIVE ANTIBACTERIAL AND ANTIPROTOZOAL AGENTS.

    Substituted phenylthioamidines
    84.
    发明授权
    Substituted phenylthioamidines 失效
    取代的苯乙胺

    公开(公告)号：US3775478A

    公开(公告)日：1973-11-27

    申请号：US3775478D

    申请日：1972-05-30

    Applicant: DOW CHEMICAL CO

    Inventor： BOCKSTAHLER E

    IPC: C07C259/14 ,  C07C123/00

    CPC classification number: C07C259/14

    Abstract: SUBSTITUTED PHENYLTHIOAMIDE COMPOUNDS SUCH AS 2-(4CHLOROPHENYLTHIO)ACETAMIDINE; 2-(4 - RHLOROPHENYLTHIO)ACETAMIDOXIME; AND THEIR PHARAMACEUTICALLY-ACCEPTABLE SALTS ARE PREPARED BY THE REACTION OF A SUBSTITUTED PHENYLTHIOACETONITRILE WITH HYDROXYLAMINE HYDROCHLORIDE OR WITH METHANOL FOLLOWED BY AMMONIUM CHLORIDE. THE COMPOUNDS HAVE ANTIMICROBIAL ACTIVITY AND ALSO INHIBIT ADPINDUCED AGGREGATION OF BLOOD PLATELETS.

    N-halo-n-phenyl-n'n'-dimethyl-formamidinium halides
    85.
    发明授权
    N-halo-n-phenyl-n'n'-dimethyl-formamidinium halides 失效
    N-卤代-N-苯基-N'-二甲基甲酰胺

    公开(公告)号：US3748360A

    公开(公告)日：1973-07-24

    申请号：US3748360D

    申请日：1972-07-26

    Applicant: EXXON RESEARCH ENGINEERING CO

    Inventor： MILLER A

    IPC: C07C123/00

    CPC classification number: C06B43/00

    Abstract: N-HALO-N-PHENYL-N''N''-DIMETHYLFORMAMIDINIUM HALIDES CHARACTERIZED BY THE FOLLOWING STRUCTURAL FORMULA:

    (((R)N-PHENYL)-N(-X)=CH-N(-CH3)2)(+) X(-)

    WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, C1-C6 ALKOXY, C1-C6 ALKYLTHIO, C1-C6 ALKYL, BROMINE AND CHLORINE; N IS AN INTEGER RANGING FROM 1 TO 4; X IS ONE SELECTED FROM THE GROUP CONSISTING OF BROMINE AND CHLORINE. THESE COMPOUNDS POSSESS PESTICIDAL ACTIVITY AND SHOW ESPECIALLY GOOD FUNGICIDAL ACTIVITY.

    Chemical compounds, processes for their preparation, and pharmaceutical compositions incorporating the same
    86.
    发明授权
    Chemical compounds, processes for their preparation, and pharmaceutical compositions incorporating the same 失效
    化学化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US3742050A

    公开(公告)日：1973-06-26

    申请号：US3742050D

    申请日：1970-02-16

    Applicant: BURROUGHS WELLCOME CO

    Inventor： HODSON H

    IPC: A61K31/155 ,  A61K31/38 ,  C07C67/00 ,  C07C239/00 ,  C07C257/14 ,  C07D333/16 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D333/36 ,  C07C123/00

    CPC classification number: C07C255/00 ,  C07D333/16 ,  C07D333/28

    Abstract: An amidine of general formula I, as shown in the accompanying drawings, or an acid addition salt thereof wherein: R1 and R2 are the same of different and each is a phenyl or thien-2-yl group, optionally substituted in one or more positions by a substituent selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, trifluoromethyl, phenyl, phenoxy, phenyl-(lower alkyl) and phenyl-(lower alkoxy), each of said phenyl, phenoxy, phenyl-(lower alkyl) and phenyl-(lower alkoxy) substituent groups being optionally substituted in one or more positions by a member selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy and lower alkylthio; A1 is a divalent straight or branched alkylene group containing from two to six carbon atoms and one or two divalent atoms which are each an oxygen or sulphur atom, provided that there are at least two carbon atoms between the divalent atom and the -NHgroup and between the two divalent atoms; A2 is a straight or branched alkylene chain containing from one to four carbon atoms; and Z is a member selected from the class consisting of hydrogen and lower alkyl. The compounds are specific antagonists of serotonin, useful specifically as antipressor agents, anticontracting agents and anti-inflammatory agents. Their high activity is maintained for at least 24 hours.

    Abstract translation: 如附图所示的通式I的脒或其酸加成盐，其中：R 1和R 2相同，各自为苯基或噻吩-2-基，任选在一个或多个位置上被取代 选自卤素，低级烷基，低级烷氧基，羟基，低级烷硫基，三氟甲基，苯基，苯氧基，苯基 - （低级烷基）和苯基 - （低级烷氧基）的取代基，各自为苯基，苯氧基，苯基 - （低级烷基）和苯基 - （低级烷氧基）取代基任选在一个或多个位置被选自卤素，低级烷基，低级烷氧基，羟基和低级烷硫基的成员取代; A 1是含有2至6个碳原子和一个或两个二价原子的二价直链或支链亚烷基，它们各自为氧或硫原子，条件是在二价原子和-NH- 两个二价原子之间; A2是含有1-4个碳原子的直链或支链亚烷基链; Z为选自氢和低级烷基的成员。

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