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    3-amino-benzo [D] isothiazole dioxide derivatives and their use as pesticides
    82.
    发明授权
    3-amino-benzo [D] isothiazole dioxide derivatives and their use as pesticides 失效
    3-氨基 - 苯并[D]异噻唑二氧化物衍生物及其作为农药的用途

    公开(公告)号：US08563744B2

    公开(公告)日：2013-10-22

    申请号：US12993983

    申请日：2009-05-18

    申请人： Werner Zambach ,  Ottmar Franz Hueter ,  Peter Renold ,  Thomas Pitterna ,  Peter Maienfisch

    发明人： Werner Zambach ,  Ottmar Franz Hueter ,  Peter Renold ,  Thomas Pitterna ,  Peter Maienfisch

    IPC分类号： C07D275/06 ,  A61K31/425

    CPC分类号： C07D275/06

    摘要： A compound of Formula (I) or Formula (II) where W is C—R3; X is C—R4; Y is C—R5; R1 and R6, independently of each other, is, for example, H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl or C1-C6-alkyl-C(═O); R2 is H; and R3, R4 and R5, independently of each other, are, for example, H, halogen, cyano, nitro, C1-C6-alkyl, or C1-C6-haloalkyl; provided that in formula II R1 is H and R6 is as defined above; and in formula I that (a) at least one of R1 and R3 to R6 is other than hydrogen, (b) R3 or R4 is other than C1 when in each instance the remaining five groups of R1 to R6 are hydrogen, and (c) (i) R3 is other than methyl, (ii) R4 is other than C1, (iii) R5 is other than C1 and (iv) R3 is not C1 when R5 is methoxy, when in each instance (i) to (iv) R1 is H, R6 is MeC(═O), and remaining groups of R2 to R5 are hydrogen; and/or salts thereof; and their use as as pesticidal agents.

    摘要翻译： 式（I）或式（II）的化合物，其中W是C-R 3; X是C-R4; Y为C-R5; R 1和R 6彼此独立地是例如H，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，C 3 -C 8 - 环烷基或C 1 -C 6 - 烷基-C（= O ）; R2为H; 和R 3，R 4和R 5彼此独立地是例如H，卤素，氰基，硝基，C 1 -C 6烷基或C 1 -C 6卤代烷基; 条件是式Ⅱ中R 1为H且R 6如上定义; （a）R1和R3至R6中的至少一个不是氢，（b）R 3或R 4不同于C 1，当R 5至R 6的剩余五个基团为氢时，和（c ）（i）R 3不是甲基，（ⅱ）R 4不是C 1，（ⅲ）R 5不是C 1，（ⅳ）当R 5是甲氧基时，R 3不是C 1，当（i）〜 ）R1为H，R6为MeC（= O），R2至R5的其余基团为氢; 和/或其盐; 以及其作为杀虫剂的用途。

    Heterocyclic derivative and use thereof
    87.
    发明授权
    Heterocyclic derivative and use thereof 失效
    杂环衍生物及其用途

    公开(公告)号：US08461348B2

    公开(公告)日：2013-06-11

    申请号：US12936291

    申请日：2009-04-03

    申请人： Nobuyuki Matsunaga ,  Yoshihisa Nakada ,  Yusuke Ohba ,  Hideyuki Nakagawa

    发明人： Nobuyuki Matsunaga ,  Yoshihisa Nakada ,  Yusuke Ohba ,  Hideyuki Nakagawa

    IPC分类号： C07D277/20 ,  C07D277/62 ,  A61K31/425

    CPC分类号： C07D263/32 ,  C07D271/04 ,  C07D271/10 ,  C07D277/20 ,  C07D277/30 ,  C07D285/12 ,  C07D307/54 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like.An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.

    摘要翻译： 本发明旨在提供具有优异的药理作用，理化特性等并可用作sGC活化药物或用于预防和/或治疗高血压，缺血性心脏病，心力衰竭，肾脏等疾病的药剂的化合物 疾病，动脉硬化疾病，心房颤动，肺动脉高压，糖尿病，糖尿病并发症，代谢综合征，外周动脉阻塞，勃起功能障碍等。 含有由式（II）表示的化合物的sGC活化药物：其中每个符号如说明书中所定义，或其盐作为活性成分。

    Amino acid compositions
    88.
    发明授权
    Amino acid compositions 有权
    氨基酸组成

    公开(公告)号：US08455531B2

    公开(公告)日：2013-06-04

    申请号：US13038537

    申请日：2011-03-02

    申请人： Ronald Kramer ,  Alexander Nikolaidis

    发明人： Ronald Kramer ,  Alexander Nikolaidis

    IPC分类号： A61K31/425

    CPC分类号： C07D233/64 ,  C07C279/14

    摘要： An amino acid composition is disclosed. The composition includes: at least one constituent selected from the group consisting of a nitrate, a nitrite, and both; and at least one constituent amino acid selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine. Also disclosed are a method for increasing the bioabsorption of Amino Acids in a human or animal and a method for increasing vasodilative characteristics of Amino Acids in a human or animal.

    摘要翻译： 公开了一种氨基酸组合物。 该组合物包括：至少一种选自硝酸盐，亚硝酸盐和二者的组分; 以及至少一种选自精氨酸，鸟嘌呤，β-丙氨酸，瓜氨酸，肌酸，谷氨酰胺，L-组氨酸，异亮氨酸，亮氨酸，诺瓦瑞因，鸟氨酸，缬氨酸，天冬氨酸，半胱氨酸，甘氨酸，赖氨酸，甲硫氨酸 ，脯氨酸，酪氨酸和苯丙氨酸。 还公开了增加人或动物中氨基酸的生物吸收的方法和增加人或动物中氨基酸的血管舒张特征的方法。