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公开(公告)号：US08569302B2
公开(公告)日：2013-10-29
申请号：US12838684
申请日：2010-07-19
申请人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
发明人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
IPC分类号： A61K31/4965 , A61K31/535 , A61K31/505 , A61K31/44 , A61K31/425 , A61K31/41 , A61K31/38 , C07D409/14 , C07D239/02 , C07D413/14 , C07D419/14 , C07D257/04
CPC分类号： A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I的化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20110020278A1
公开(公告)日：2011-01-27
申请号：US12838684
申请日：2010-07-19
申请人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
发明人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61K31/497 , A61K31/501 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/41 , C07D417/14 , A61K31/427 , A61P31/14 , A61K38/21 , A61K31/7056
CPC分类号： A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I的化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US08524764B2
公开(公告)日：2013-09-03
申请号：US13006761
申请日：2011-01-14
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US08741946B2
公开(公告)日：2014-06-03
申请号：US13549130
申请日：2012-07-13
申请人： William J. Watkins , Eda Canales , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith
发明人： William J. Watkins , Eda Canales , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith
IPC分类号： A61K31/381 , C07D333/10
CPC分类号： C07D333/40
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug resistant Flaviviridae virus infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 提供的化合物，组合物和方法可用于治疗黄病毒科病毒感染（例如丙型肝炎感染），特别是耐药性黄病毒科病毒感染。
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公开(公告)号：US08513298B2
公开(公告)日：2013-08-20
申请号：US13007150
申请日：2011-01-14
申请人： Eda Canales , Michael O'Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
发明人： Eda Canales , Michael O'Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC分类号： A61K31/381 , C07D409/12 , C07D333/36 , C07D333/38
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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6.发明授权2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections 有权2,4,6-三取代吡啶并（3,2-d）嘧啶可用于治疗病毒感染公开(公告)号：US08536187B2
公开(公告)日：2013-09-17
申请号：US12996110
申请日：2009-07-01
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D471/04
摘要： Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
摘要翻译： 由结构式（Ia）表示的吡啶并（3,2-d）嘧啶衍生物：其中R1，R2和R3如本文所定义，药学上可接受的加成盐，立体化学异构形式，N-氧化物，溶剂化物和其前体药物， 用于治疗丙型肝炎。
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7.发明申请2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS 有权用于治疗病毒感染的2,4,6-三唑吡啶（3,2-d）吡咯烷酮公开(公告)号：US20110123493A1
公开(公告)日：2011-05-26
申请号：US12996110
申请日：2009-07-01
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K38/21 , C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/7056 , A61P31/14 , A61P39/00
CPC分类号： C07D471/04
摘要： Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
摘要翻译： 由结构式（Ia）表示的吡啶并（3,2-d）嘧啶衍生物：其中R1，R2和R3如本文所定义，药学上可接受的加成盐，立体化学异构形式，N-氧化物，溶剂化物和其前体药物， 用于治疗丙型肝炎。
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公开(公告)号：US20110178129A1
公开(公告)日：2011-07-21
申请号：US13007150
申请日：2011-01-14
申请人： Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
发明人： Eda Canales , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Philip Anthony Morganelli , William J. Watkins
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61P31/14 , C07D333/36
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US08575118B2
公开(公告)日：2013-11-05
申请号：US13553517
申请日：2012-07-19
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130137877A1
公开(公告)日：2013-05-30
申请号：US13553517
申请日：2012-07-19
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard Mackman , Hyung-Jun Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： C07D403/14 , C07D403/04 , C07F5/02
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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