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公开(公告)号：US08569302B2
公开(公告)日：2013-10-29
申请号：US12838684
申请日：2010-07-19
申请人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
发明人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
IPC分类号： A61K31/4965 , A61K31/535 , A61K31/505 , A61K31/44 , A61K31/425 , A61K31/41 , A61K31/38 , C07D409/14 , C07D239/02 , C07D413/14 , C07D419/14 , C07D257/04
CPC分类号： A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I的化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20110020278A1
公开(公告)日：2011-01-27
申请号：US12838684
申请日：2010-07-19
申请人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
发明人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Mertzman , Philip A. Morganelli , William J. Watkins , Hong Ye
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4436 , A61K31/497 , A61K31/501 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/41 , C07D417/14 , A61K31/427 , A61P31/14 , A61K38/21 , A61K31/7056
CPC分类号： A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I的化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US08524764B2
公开(公告)日：2013-09-03
申请号：US13006761
申请日：2011-01-14
申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20110178058A1
公开(公告)日：2011-07-21
申请号：US13006761
申请日：2011-01-14
申请人： Eda CANALES , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
发明人： Eda CANALES , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins
IPC分类号： A61K31/381 , C07D409/14 , A61K31/4545 , C07D409/12 , A61K31/4025 , C07D493/04 , A61K31/4535 , A61K31/454 , A61K31/497 , A61K31/501 , A61P31/14
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US08741946B2
公开(公告)日：2014-06-03
申请号：US13549130
申请日：2012-07-13
申请人： William J. Watkins , Eda Canales , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith
发明人： William J. Watkins , Eda Canales , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith
IPC分类号： A61K31/381 , C07D333/10
CPC分类号： C07D333/40
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug resistant Flaviviridae virus infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 提供的化合物，组合物和方法可用于治疗黄病毒科病毒感染（例如丙型肝炎感染），特别是耐药性黄病毒科病毒感染。
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公开(公告)号：US08501714B2
公开(公告)日：2013-08-06
申请号：US13392467
申请日：2010-09-07
申请人： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
发明人： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/67 , A61K31/675 , C07F9/6558 , C07F9/6553
CPC分类号： C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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公开(公告)号：US20120156166A1
公开(公告)日：2012-06-21
申请号：US13392467
申请日：2010-09-07
申请人： Aesop Cho , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
发明人： Aesop Cho , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/67 , C07F9/6558 , A61P31/14 , C07F9/6568 , A61K38/21 , A61K31/7056 , C07F9/6553 , A61K31/675
CPC分类号： C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20090227491A1
公开(公告)日：2009-09-10
申请号：US12303219
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08927484B2
公开(公告)日：2015-01-06
申请号：US12958112
申请日：2010-12-01
申请人： Zhenhong R. Cai , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Mingzhe Ji , Choung U. Kim , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Zhenhong R. Cai , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Mingzhe Ji , Choung U. Kim , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/00 , C07D498/04 , C07D487/04 , C07D471/04
CPC分类号： C07D471/04 , A61K38/00 , C07D487/04 , C07D498/04
摘要： The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
摘要翻译： 本申请包括HCV的新型抑制剂，含有这些化合物的组合物，包括施用这些化合物的治疗方法。
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公开(公告)号：US20110135599A1
公开(公告)日：2011-06-09
申请号：US12958112
申请日：2010-12-01
申请人： Zhenhong R. Cai , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Mingzhe Ji , Choung U. Kim , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Zhenhong R. Cai , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Mingzhe Ji , Choung U. Kim , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/21 , C07D241/36 , C07D413/14 , C07D265/28 , C07D217/24 , C07D243/00 , A61K31/4985 , A61K31/5377 , A61K31/5365 , A61K31/4709 , A61K31/551 , A61K31/7056 , A61P31/14
CPC分类号： C07D471/04 , A61K38/00 , C07D487/04 , C07D498/04
摘要： The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
摘要翻译： 本申请包括HCV的新型抑制剂，含有这些化合物的组合物，包括施用这些化合物的治疗方法。
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