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公开(公告)号：US11161858B2
公开(公告)日：2021-11-02
申请号：US16856332
申请日：2020-04-23
发明人： Tsutomu Akama , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US20190160081A1
公开(公告)日：2019-05-30
申请号：US16265006
申请日：2019-02-01
发明人： Stephen J. Baker , Virginia Sanders , Tsutomo Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：US10214548B2
公开(公告)日：2019-02-26
申请号：US15801127
申请日：2017-11-01
发明人： Tsutomu Akama , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US20180044353A1
公开(公告)日：2018-02-15
申请号：US15550693
申请日：2016-02-12
发明人： Carlos ALEMPARTE-GALLARDO , M.R.K.(dickon) ALLEY , David BARROS-AGUIRRE , Ilaria GIORDANO , Vincent HERNANDEZ , Xianfeng LI , Jacob J. PLATTNER
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CH2CH3, —CH2═CH2, —CH2CH2CH3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20170327519A1
公开(公告)日：2017-11-16
申请号：US15590159
申请日：2017-05-09
发明人： Tsutomu AKAMA , David Scott CARTER , Jason S. HALLADAY , Robert T. JACOBS , Yang LIU , Jacob J. PLATTNER , Yong-Kang ZHANG , Michael John WITTY
IPC分类号： C07F5/02 , A61K31/4525 , A61K31/443 , A61K31/69 , A61K31/166 , A61K31/5377 , A61K31/4178 , A61K31/431 , A61K31/47
摘要： The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
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公开(公告)号：US09815857B2
公开(公告)日：2017-11-14
申请号：US15439634
申请日：2017-02-22
发明人： Tsutomu Akama , Eric Easom , Yvonne Freund , Jacob J. Plattner , Jessica Sligar , Daitao Chen , Jennifer Freeman , Joe Perales
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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公开(公告)号：US09572823B2
公开(公告)日：2017-02-21
申请号：US15091394
申请日：2016-04-05
发明人： Stephen J. Baker , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson , James J. Leyden
IPC分类号： A61K31/69 , C07F5/02 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , A61K31/70 , A61K31/7076 , A61K9/00 , A61K47/10 , A61K9/08
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US09156860B2
公开(公告)日：2015-10-13
申请号：US14507453
申请日：2014-10-06
发明人： Tsutomu Akama , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
摘要： This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
摘要翻译： 本发明提供新化合物，使用该化合物的方法和包含该化合物的药物制剂。
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公开(公告)号：US08623911B2
公开(公告)日：2014-01-07
申请号：US13636114
申请日：2011-03-18
申请人： Robert T. Jacobs , Daitao Chen , Matthew Orr , Jacob J. Plattner
发明人： Robert T. Jacobs , Daitao Chen , Matthew Orr , Jacob J. Plattner
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US20130316979A1
公开(公告)日：2013-11-28
申请号：US13954770
申请日：2013-07-30
发明人： Stephen J. Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
IPC分类号： C07F5/02
CPC分类号： A61K31/69 , C07F5/027 , Y02A50/411
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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